LOCUS       NM_001015                573 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S11 (RPS11), mRNA.
ACCESSION   NM_001015
VERSION     NM_001015.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 573)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 573)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 573)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 573)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 573)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   6  (bases 1 to 573)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 573)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (bases 1 to 573)
  AUTHORS   Feo,S., Davies,B. and Fried,M.
  TITLE     The mapping of seven intron-containing ribosomal protein genes
            shows they are unlinked in the human genome
  JOURNAL   Genomics 13 (1), 201-207 (1992)
   PUBMED   1577483
REFERENCE   9  (bases 1 to 573)
  AUTHORS   Ferrari,S., Manfredini,R., Tagliafico,E., Rossi,E., Donelli,A.,
            Torelli,G. and Torelli,U.
  TITLE     Noncoordinated expression of S6, S11, and S14 ribosomal protein
            genes in leukemic blast cells
  JOURNAL   Cancer Res 50 (18), 5825-5828 (1990)
   PUBMED   1697501
REFERENCE   10 (bases 1 to 573)
  AUTHORS   Lott,J.B. and Mackie,G.A.
  TITLE     Sequence of a cloned cDNA encoding human ribosomal protein S11
  JOURNAL   Nucleic Acids Res 16 (3), 1205 (1988)
   PUBMED   3267208
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AK311809.1 and BI550467.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001015.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a member of the
            S17P family of ribosomal proteins that is a component of the 40S
            subunit. This gene is co-transcribed with the small nucleolar RNA
            gene U35B, which is located in the third intron. As is typical for
            genes encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed throughout the genome. [provided
            by RefSeq, Jul 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP344052.1, BI550467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270625.7/ ENSP00000270625.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               AK311809.1         5-504
            501-573             BI550467.1         506-578
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..573
                     /gene="RPS11"
                     /gene_synonym="S11; uS17"
                     /note="ribosomal protein S11"
                     /db_xref="GeneID:6205"
                     /db_xref="HGNC:HGNC:10384"
                     /db_xref="MIM:180471"
     exon            1..38
                     /gene="RPS11"
                     /gene_synonym="S11; uS17"
                     /inference="alignment:Splign:2.1.0"
     exon            39..170
                     /gene="RPS11"
                     /gene_synonym="S11; uS17"
                     /inference="alignment:Splign:2.1.0"
     exon            171..246
                     /gene="RPS11"
                     /gene_synonym="S11; uS17"
                     /inference="alignment:Splign:2.1.0"
     exon            247..376
                     /gene="RPS11"
                     /gene_synonym="S11; uS17"
                     /inference="alignment:Splign:2.1.0"
     exon            377..573
                     /gene="RPS11"
                     /gene_synonym="S11; uS17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      531..536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS11"
                     /gene_synonym="S11; uS17"
                     /note="hexamer: AATAAA"
     polyA_site      554
                     /gene="RPS11"
                     /gene_synonym="S11; uS17"
                     /note="major polyA site"
ORIGIN      
        1 ctttttttca ggcggccggg aagatggcgg acattcagac tgagcgtgcc taccaaaagc
       61 agccgaccat ctttcaaaac aagaagaggg tcctgctggg agaaactggc aaggagaagc
      121 tcccgcggta ctacaagaac atcggtctgg gcttcaagac acccaaggag gctattgagg
      181 gcacctacat tgacaagaaa tgccccttca ctggtaatgt gtccattcga gggcggatcc
      241 tctctggcgt ggtgaccaag atgaagatgc agaggaccat tgtcatccgc cgagactatc
      301 tgcactacat ccgcaagtac aaccgcttcg agaagcgcca caagaacatg tctgtacacc
      361 tgtccccctg cttcagggac gtccagatcg gtgacatcgt cacagtgggc gagtgccggc
      421 ctctgagcaa gacagtgcgc ttcaacgtgc tcaaggtcac caaggctgcc ggcaccaaga
      481 agcagttcca gaagttctga ggctggacat cggcccgctc cccacaatga aataaagtta
      541 ttttctcatt cccaggccag acttgggatc ttc
//
