LOCUS       NM_001202470            2473 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens RPS10-NUDT3 readthrough (RPS10-NUDT3), mRNA.
ACCESSION   NM_001202470
VERSION     NM_001202470.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2473)
  AUTHORS   Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G,
            Jackson AU, Lango Allen H, Lindgren CM, Luan J, Magi R, Randall JC,
            Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM,
            Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR,
            Ferreira T, Weyant RJ, Segre AV, Estrada K, Liang L, Nemesh J, Park
            JH, Gustafsson S, Kilpelainen TO, Yang J, Bouatia-Naji N, Esko T,
            Feitosa MF, Kutalik Z, Mangino M, Raychaudhuri S, Scherag A, Smith
            AV, Welch R, Zhao JH, Aben KK, Absher DM, Amin N, Dixon AL, Fisher
            E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ,
            Johansson A, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers
            RH, Narisu N, Perry JR, Peters MJ, Preuss M, Ripatti S, Rivadeneira
            F, Sandholt C, Scott LJ, Timpson NJ, Tyrer JP, van Wingerden S,
            Watanabe RM, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper
            MN, Jansson JO, Lawrence RW, Pellikka N, Prokopenko I, Shi J,
            Thiering E, Alavere H, Alibrandi MT, Almgren P, Arnold AM, Aspelund
            T, Atwood LD, Balkau B, Balmforth AJ, Bennett AJ, Ben-Shlomo Y,
            Bergman RN, Bergmann S, Biebermann H, Blakemore AI, Boes T,
            Bonnycastle LL, Bornstein SR, Brown MJ, Buchanan TA, Busonero F,
            Campbell H, Cappuccio FP, Cavalcanti-Proenca C, Chen YD, Chen CM,
            Chines PS, Clarke R, Coin L, Connell J, Day IN, den Heijer M, Duan
            J, Ebrahim S, Elliott P, Elosua R, Eiriksdottir G, Erdos MR,
            Eriksson JG, Facheris MF, Felix SB, Fischer-Posovszky P, Folsom AR,
            Friedrich N, Freimer NB, Fu M, Gaget S, Gejman PV, Geus EJ, Gieger
            C, Gjesing AP, Goel A, Goyette P, Grallert H, Grassler J,
            Greenawalt DM, Groves CJ, Gudnason V, Guiducci C, Hartikainen AL,
            Hassanali N, Hall AS, Havulinna AS, Hayward C, Heath AC,
            Hengstenberg C, Hicks AA, Hinney A, Hofman A, Homuth G, Hui J, Igl
            W, Iribarren C, Isomaa B, Jacobs KB, Jarick I, Jewell E, John U,
            Jorgensen T, Jousilahti P, Jula A, Kaakinen M, Kajantie E, Kaplan
            LM, Kathiresan S, Kettunen J, Kinnunen L, Knowles JW, Kolcic I,
            Konig IR, Koskinen S, Kovacs P, Kuusisto J, Kraft P, Kvaloy K,
            Laitinen J, Lantieri O, Lanzani C, Launer LJ, Lecoeur C, Lehtimaki
            T, Lettre G, Liu J, Lokki ML, Lorentzon M, Luben RN, Ludwig B,
            Manunta P, Marek D, Marre M, Martin NG, McArdle WL, McCarthy A,
            McKnight B, Meitinger T, Melander O, Meyre D, Midthjell K,
            Montgomery GW, Morken MA, Morris AP, Mulic R, Ngwa JS, Nelis M,
            Neville MJ, Nyholt DR, O'Donnell CJ, O'Rahilly S, Ong KK, Oostra B,
            Pare G, Parker AN, Perola M, Pichler I, Pietilainen KH, Platou CG,
            Polasek O, Pouta A, Rafelt S, Raitakari O, Rayner NW, Ridderstrale
            M, Rief W, Ruokonen A, Robertson NR, Rzehak P, Salomaa V, Sanders
            AR, Sandhu MS, Sanna S, Saramies J, Savolainen MJ, Scherag S,
            Schipf S, Schreiber S, Schunkert H, Silander K, Sinisalo J,
            Siscovick DS, Smit JH, Soranzo N, Sovio U, Stephens J, Surakka I,
            Swift AJ, Tammesoo ML, Tardif JC, Teder-Laving M, Teslovich TM,
            Thompson JR, Thomson B, Tonjes A, Tuomi T, van Meurs JB, van Ommen
            GJ, Vatin V, Viikari J, Visvikis-Siest S, Vitart V, Vogel CI,
            Voight BF, Waite LL, Wallaschofski H, Walters GB, Widen E, Wiegand
            S, Wild SH, Willemsen G, Witte DR, Witteman JC, Xu J, Zhang Q,
            Zgaga L, Ziegler A, Zitting P, Beilby JP, Farooqi IS, Hebebrand J,
            Huikuri HV, James AL, Kahonen M, Levinson DF, Macciardi F, Nieminen
            MS, Ohlsson C, Palmer LJ, Ridker PM, Stumvoll M, Beckmann JS,
            Boeing H, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ,
            Collins FS, Cupples LA, Smith GD, Erdmann J, Froguel P, Gronberg H,
            Gyllensten U, Hall P, Hansen T, Harris TB, Hattersley AT, Hayes RB,
            Heinrich J, Hu FB, Hveem K, Illig T, Jarvelin MR, Kaprio J, Karpe
            F, Khaw KT, Kiemeney LA, Krude H, Laakso M, Lawlor DA, Metspalu A,
            Munroe PB, Ouwehand WH, Pedersen O, Penninx BW, Peters A,
            Pramstaller PP, Quertermous T, Reinehr T, Rissanen A, Rudan I,
            Samani NJ, Schwarz PE, Shuldiner AR, Spector TD, Tuomilehto J, Uda
            M, Uitterlinden A, Valle TT, Wabitsch M, Waeber G, Wareham NJ,
            Watkins H, Wilson JF, Wright AF, Zillikens MC, Chatterjee N,
            McCarroll SA, Purcell S, Schadt EE, Visscher PM, Assimes TL,
            Borecki IB, Deloukas P, Fox CS, Groop LC, Haritunians T, Hunter DJ,
            Kaplan RC, Mohlke KL, O'Connell JR, Peltonen L, Schlessinger D,
            Strachan DP, van Duijn CM, Wichmann HE, Frayling TM,
            Thorsteinsdottir U, Abecasis GR, Barroso I, Boehnke M, Stefansson
            K, North KE, McCarthy MI, Hirschhorn JN, Ingelsson E and Loos RJ.
  CONSRTM   MAGIC; Procardis Consortium
  TITLE     Association analyses of 249,796 individuals reveal 18 new loci
            associated with body mass index
  JOURNAL   Nat. Genet. 42 (11), 937-948 (2010)
   PUBMED   20935630
REFERENCE   2  (bases 1 to 2473)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS ONE 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2473)
  AUTHORS   Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N,
            Yokoyama-Kobayashi M and Aoki T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157372.18, BU521288.1 and
            Z98036.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001202470.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring RPS10 (ribosomal protein S10)
            and NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type
            motif 3) genes on chromosome 6. The read-through transcript
            produces a fusion protein that shares sequence identity with each
            individual gene product. [provided by RefSeq, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.210058.1, BU521288.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155371 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 6204, 11165
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL157372.18        11335-11355         c
            22-794              BU521288.1         1-773
            795-2473            Z98036.1           4705-6383           c
FEATURES             Location/Qualifiers
     source          1..2473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..2473
                     /gene="RPS10-NUDT3"
                     /note="RPS10-NUDT3 readthrough"
                     /db_xref="GeneID:100529239"
                     /db_xref="HGNC:HGNC:49181"
     exon            1..38
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..914
                     /gene="RPS10-NUDT3"
                     /note="ribosomal protein S10 homologue"
                     /codon_start=1
                     /product="RPS10-NUDT3 protein"
                     /protein_id="NP_001189399.1"
                     /db_xref="GeneID:100529239"
                     /db_xref="HGNC:HGNC:49181"
                     /translation="MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLH
                     VMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETG
                     RPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFVLLVSSSR
                     HPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLI
                     VTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVA
                     TTYSVSAQSSMSGIR"
     exon            39..188
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     exon            189..360
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     exon            361..438
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..494
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     exon            495..605
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..650
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..735
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..2473
                     /gene="RPS10-NUDT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1294..1299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS10-NUDT3"
                     /note="hexamer: ATTAAA"
     polyA_site      1328
                     /gene="RPS10-NUDT3"
                     /note="major polyA site"
     regulatory      1427..1432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS10-NUDT3"
                     /note="hexamer: AATAAA"
     polyA_site      1451
                     /gene="RPS10-NUDT3"
                     /note="major polyA site"
     regulatory      2450..2455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS10-NUDT3"
                     /note="hexamer: AATAAA"
     polyA_site      2473
                     /gene="RPS10-NUDT3"
ORIGIN      
        1 cctttccagc cccggtaccg gaccctgcag ccgcagagat gttgatgcct aagaagaacc
       61 ggattgccat ttatgaactc ctttttaagg agggagtcat ggtggccaag aaggatgtcc
      121 acatgcctaa gcacccggag ctggcagaca agaatgtgcc caaccttcat gtcatgaagg
      181 ccatgcagtc tctcaagtcc cgaggctacg tgaaggaaca gtttgcctgg agacatttct
      241 actggtacct taccaatgag ggtatccagt atctccgtga ttaccttcat ctgcccccgg
      301 agattgtgcc tgccacccta cgccgtagcc gtccagagac tggcaggcct cggcctaaag
      361 gtctggaggg tgagcgacct gcgagactca caagagggga agctgacaga gatacctaca
      421 gacggagtgc tgtgccacct ggtgccgaca agaaagccga ggctggggct gggtcagcaa
      481 ccgaattcca gtttgtgcta ctcgtgagca gtagtcgcca tccagacaga tggattgtcc
      541 ctggaggagg catggagccc gaggaggagc caagtgtggc agcagttcgt gaagtctgtg
      601 aggaggctgg agtaaaaggg acattgggaa gattagttgg aatttttgag aaccaggaga
      661 ggaagcacag gacgtatgtc tatgtgctca ttgtcactga agtgctggaa gactgggaag
      721 attcagttaa cattggaagg aagagggaat ggtttaaaat agaagacgcc ataaaagtgc
      781 tgcagtatca caaacccgtg caggcatcat attttgaaac attgaggcaa ggctactcag
      841 ccaacaatgg caccccagtc gtggccacca catactcggt ttctgctcag agctcgatgt
      901 caggcatcag atgactgaag acttcctgta agagaaatgg aaattggaaa ctagactgaa
      961 gtgcaaatct tccctctcac cctggctctt tccacttctc acaggcctcc tctttcaaat
     1021 aaggcatggt gggcagcaaa gaaagggtgt attgataatg ttgctgtttg gtgttaagtg
     1081 atggggcttt ttcttctgtt tttattgagg gtgggggttg ggtgtgtaat ttgtaagtac
     1141 ttttgtgcat gatctgtccc tccctcttcc cacccctgca gtcctctgaa gagaggccaa
     1201 cagccttccc ctgccttgga ttctgaagtg ttcctgtttg tcttatcctg gccctggcca
     1261 gacgttttct ttgattttta attttttttt tttattaaaa gataccagta tgagatgaaa
     1321 acttccaata atttgtccta taatgtgctg tacagttcag tagagtggtc actttcactg
     1381 cagtatacat ttatctacac attatatatc ggacatataa tatgtaaata aatgacttct
     1441 agaaagagaa atttgtttaa tttttcaagg tttttttctc ttttaatttg ggcatttcta
     1501 gaattgagag cctcacaatt aacatacctt tttgttttcg atgctagtgg ctgggcaggt
     1561 tgccctgtcc tttctctatt tcccagtcat tgactgtaga tatgggaaga gtttagctac
     1621 cttcatagtg ctcccaggac tcatggcctt tccttcttta agctgtattt ccctgcccag
     1681 aaagaaacag gaagaaacct ttttttattt ttttattttt ttttaaccaa gcaaggagca
     1741 aatggcctca gcccagatct gtaaaaacaa tgatagaaat tgaattctgc cccacatgtt
     1801 gacagtagag ttggaactgg attcttggga ttacttatct aaaaaactgg agcatcaggt
     1861 ccatttctgt tctgctggtt tggaatcttt tccgtaatgc tatttattgc caacaatggc
     1921 ctctctttgt gtccatatat gccttacacc gtgctgacct gggtatcatc catgtgctct
     1981 gaagcatcca actttacttt gcaggtgcat caatgtagtc ctgtccctga actgagtaac
     2041 cgtgttcctg aaaagtacac tagggaaatt cacctgcttg cttgtctttg tattggcatg
     2101 gcacttgtga ttgcaccatg gagcatgctc agagctatta aattggtctc ccatctccca
     2161 ccaggatatg aaaggtccat atgggaggcc acgtaatcac ttattacagt ggttacataa
     2221 tacactggct cactgcagac tctcttgttt tttgatacag tttcgtgctg gcttcatttg
     2281 ccaattgtgt tgtttagttc ggaagtaaga gggtcttgag attgaggggt agggagggct
     2341 acactgactg atccgtggct taagacagga gattatctct gtactccagt ggcatctcct
     2401 tagccaagat gtgaaattaa aatcatagtt cgcctcattt aaaaattcta ataaagcact
     2461 caaactttga aaa
//
