LOCUS       NM_001014                588 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2,
            mRNA.
ACCESSION   NM_001014 XM_499468
VERSION     NM_001014.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 588)
  AUTHORS   Ugajin,N., Imami,K., Takada,H., Ishihama,Y., Chiba,S. and
            Mishima,Y.
  TITLE     Znf598-mediated Rps10/eS10 ubiquitination contributes to the
            ribosome ubiquitination dynamics during zebrafish development
  JOURNAL   RNA 29 (12), 1910-1927 (2023)
   PUBMED   37751929
  REMARK    GeneRIF: Znf598-mediated Rps10/eS10 ubiquitination contributes to
            the ribosome ubiquitination dynamics during zebrafish development.
REFERENCE   2  (bases 1 to 588)
  AUTHORS   Li,J., Su,Y., Chen,L., Lin,Y. and Ru,K.
  TITLE     Identification of novel mutations in patients with Diamond-Blackfan
            anemia and literature review of RPS10 and RPS26 mutations
  JOURNAL   Int J Lab Hematol 45 (5), 766-773 (2023)
   PUBMED   37376976
  REMARK    GeneRIF: Identification of novel mutations in patients with
            Diamond-Blackfan anemia and literature review of RPS10 and RPS26
            mutations.
            Review article
REFERENCE   3  (bases 1 to 588)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 588)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 588)
  AUTHORS   Malygin,A.A., Shaulo,D.D. and Karpova,G.G.
  TITLE     Proteins S7, S10, S16 and S19 of the human 40S ribosomal subunit
            are most resistant to dissociation by salt
  JOURNAL   Biochim Biophys Acta 1494 (3), 213-216 (2000)
   PUBMED   11121577
REFERENCE   6  (bases 1 to 588)
  AUTHORS   Pei,L.
  TITLE     Pituitary tumor-transforming gene protein associates with ribosomal
            protein S10 and a novel human homologue of DnaJ in testicular cells
  JOURNAL   J Biol Chem 274 (5), 3151-3158 (1999)
   PUBMED   9915854
REFERENCE   7  (bases 1 to 588)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 588)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   9  (bases 1 to 588)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim Biophys Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
REFERENCE   10 (bases 1 to 588)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BG940847.1, AL157372.18 and BC001032.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2018 this sequence version replaced NM_001014.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S10E family of ribosomal proteins. It is located in the
            cytoplasm. Variable expression of this gene in colorectal cancers
            compared to adjacent normal tissues has been observed, although no
            correlation between the level of expression and the severity of the
            disease has been found. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed through the genome. Alternate splicing results in
            multiple transcript variants that encode the same protein.
            Naturally occurring read-through transcription occurs between this
            locus and the neighboring locus NUDT3 (nudix (nucleoside
            diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD176128.1, CD177422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03568911 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648437.1/ ENSP00000497917.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BG940847.1         57-57
            2-2                 AL157372.18        11354-11354         c
            3-19                BG940847.1         59-75
            20-588              BC001032.2         1-569
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..588
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /note="ribosomal protein S10"
                     /db_xref="GeneID:6204"
                     /db_xref="HGNC:HGNC:10383"
                     /db_xref="MIM:603632"
     exon            1..38
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..536
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /note="40S ribosomal protein S10"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS10"
                     /protein_id="NP_001005.1"
                     /db_xref="CCDS:CCDS4792.1"
                     /db_xref="GeneID:6204"
                     /db_xref="HGNC:HGNC:10383"
                     /db_xref="MIM:603632"
                     /translation="MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLH
                     VMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETG
                     RPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGR
                     GQPPQ"
     exon            39..188
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /inference="alignment:Splign:2.1.0"
     exon            189..360
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /inference="alignment:Splign:2.1.0"
     exon            361..438
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /inference="alignment:Splign:2.1.0"
     exon            439..494
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /inference="alignment:Splign:2.1.0"
     exon            495..588
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      562..567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /note="hexamer: AATAAA"
     polyA_site      588
                     /gene="RPS10"
                     /gene_synonym="DBA9; eS10; S10"
                     /note="major polyA site"
ORIGIN      
        1 cctttccagc cccggtaccg gaccctgcag ccgcagagat gttgatgcct aagaagaacc
       61 ggattgccat ttatgaactc ctttttaagg agggagtcat ggtggccaag aaggatgtcc
      121 acatgcctaa gcacccggag ctggcagaca agaatgtgcc caaccttcat gtcatgaagg
      181 ccatgcagtc tctcaagtcc cgaggctacg tgaaggaaca gtttgcctgg agacatttct
      241 actggtacct taccaatgag ggtatccagt atctccgtga ttaccttcat ctgcccccgg
      301 agattgtgcc tgccacccta cgccgtagcc gtccagagac tggcaggcct cggcctaaag
      361 gtctggaggg tgagcgacct gcgagactca caagagggga agctgacaga gatacctaca
      421 gacggagtgc tgtgccacct ggtgccgaca agaaagccga ggctggggct gggtcagcaa
      481 ccgaattcca gtttagaggc ggatttggtc gtggacgtgg tcagccacct cagtaaaatt
      541 ggagaggatt cttttgcatt gaataaactt acagccaaaa aaccttaa
//
