LOCUS       NP_981945                120 aa            linear   PRI 28-APR-2025
DEFINITION  reprimo-like protein [Homo sapiens].
ACCESSION   NP_981945 XP_371061
VERSION     NP_981945.1
DBSOURCE    REFSEQ: accession NM_203400.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 120)
  AUTHORS   Alarcon,M.A., Olivares,W., Cordova-Delgado,M., Munoz-Medel,M., de
            Mayo,T., Carrasco-Avino,G., Wichmann,I., Landeros,N., Amigo,J.,
            Norero,E., Villarroel-Espindola,F., Riquelme,A., Garrido,M.,
            Owen,G.I. and Corvalan,A.H.
  TITLE     The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor
            and a Candidate Biomarker for the Non-Invasive Detection of Gastric
            Cancer
  JOURNAL   Int J Mol Sci 21 (24), 9472 (2020)
   PUBMED   33322837
  REMARK    GeneRIF: The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor
            Suppressor and a Candidate Biomarker for the Non-Invasive Detection
            of Gastric Cancer.
            GeneRIF: Our results suggest that RPRML is a TSG, downregulated by
            DNA methylation in GC, and that circulating methylated RPRML DNA
            can distinguish patients with GC from cancer-free controls. Thus,
            these findings provide justification for larger clinical studies to
            further assess its value in multi-biomarker panel approaches for
            non-invasive diagnosis of GC.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 120)
  AUTHORS   Amigo,J.D., Opazo,J.C., Jorquera,R., Wichmann,I.A.,
            Garcia-Bloj,B.A., Alarcon,M.A., Owen,G.I. and Corvalan,A.H.
  TITLE     The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer
            with Tumor Suppressive Properties
  JOURNAL   Int J Mol Sci 19 (7), 1862 (2018)
   PUBMED   29941787
  REMARK    GeneRIF: rawing on embryonic and adult expression patterns, we
            address the potential relevance of RPRM and RPRML in cancer. Active
            investigation or analytical research in the coming years should
            contribute to novel translational applications of this poorly
            understood gene family as potential biomarkers and development of
            novel cancer therapies.
            Review article
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005670.1 and BC033942.1.
            
            On Mar 22, 2004 this sequence version replaced XP_371061.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC033942.1, BI831481.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322329.5/ ENSP00000318032.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..120
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     Protein         1..120
                     /product="reprimo-like protein"
                     /calculated_mol_wt=12181
     Site            67..87
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N4K4.2)"
     Site            109
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q3URD2; propagated from
                     UniProtKB/Swiss-Prot (Q8N4K4.2)"
     CDS             1..120
                     /gene="RPRML"
                     /coded_by="NM_203400.5:247..609"
                     /db_xref="CCDS:CCDS11508.1"
                     /db_xref="GeneID:388394"
                     /db_xref="HGNC:HGNC:32422"
ORIGIN      
        1 mnatflnhsg leevdgvggg agaalgnrth glgtwlgccp ggaplaasdg vpaglapder
       61 slwvsrvaqi avlcvlsltv vfgvfflgcn lliksesmin flvqerrpsk dvgaailgly
//
