LOCUS       NM_019845               1425 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens reprimo, TP53 dependent G2 arrest mediator homolog
            (RPRM), mRNA.
ACCESSION   NM_019845
VERSION     NM_019845.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Wu,Y. and Du,J.
  TITLE     Downregulated Reprimo by LINC00467 participates in the growth and
            metastasis of gastric cancer
  JOURNAL   Bioengineered 13 (5), 11893-11906 (2022)
   PUBMED   35549646
  REMARK    GeneRIF: Downregulated Reprimo by LINC00467 participates in the
            growth and metastasis of gastric cancer.
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Amigo,J.D., Opazo,J.C., Jorquera,R., Wichmann,I.A.,
            Garcia-Bloj,B.A., Alarcon,M.A., Owen,G.I. and Corvalan,A.H.
  TITLE     The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer
            with Tumor Suppressive Properties
  JOURNAL   Int J Mol Sci 19 (7), 1862 (2018)
   PUBMED   29941787
  REMARK    GeneRIF: rawing on embryonic and adult expression patterns, we
            address the potential relevance of RPRM and RPRML in cancer. Active
            investigation or analytical research in the coming years should
            contribute to novel translational applications of this poorly
            understood gene family as potential biomarkers and development of
            novel cancer therapies.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Nakazato,T., Suzuki,Y., Tanaka,R., Abe,N., Masaki,T., Mori,T.,
            Ohkura,Y. and Sugiyama,M.
  TITLE     Effect of Reprimo Down-regulation on Malignant Transformation of
            Intraductal Papillary Mucinous Neoplasm
  JOURNAL   Pancreas 47 (3), 291-295 (2018)
   PUBMED   29401170
  REMARK    GeneRIF: Reprimo methylation was found more frequently in malignant
            intraductal papillary mucinous neoplasm (IPMN), suggesting reprimo
            methylation is involved in malignant transformation of IPMNs.
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Buchegger,K., Riquelme,I., Viscarra,T., Ili,C., Brebi,P.,
            Huang,T.H. and Roa,J.C.
  TITLE     Reprimo, a Potential p53-Dependent Tumor Suppressor Gene, Is
            Frequently Hypermethylated in Estrogen Receptor alpha-Positive
            Breast Cancer
  JOURNAL   Int J Mol Sci 18 (8), 1525 (2017)
   PUBMED   28809778
  REMARK    GeneRIF: data suggest that ERalpha expression in breast cancer may
            affect the DNA methylation of CpG-island in the RPRM gene.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Bernal,C., Aguayo,F., Villarroel,C., Vargas,M., Diaz,I.,
            Ossandon,F.J., Santibanez,E., Palma,M., Aravena,E., Barrientos,C.
            and Corvalan,A.H.
  TITLE     Reprimo as a potential biomarker for early detection in gastric
            cancer
  JOURNAL   Clin Cancer Res 14 (19), 6264-6269 (2008)
   PUBMED   18829507
  REMARK    GeneRIF: Aberrant hypermethylation of Reprimo is high in primary
            gastric cancer as well as in pair plasma samples. In plasma from
            asymptomatic controls, Reprimo is infrequently methylated. Reprimo
            is a potential biomarker for early detection of gastric cancer.
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Beasley,W.D., Beynon,J., Jenkins,G.J. and Parry,J.M.
  TITLE     Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms
            and colorectal cancer: a case-control disease association study
  JOURNAL   Int J Colorectal Dis 23 (4), 375-381 (2008)
   PUBMED   18197409
  REMARK    GeneRIF: An association between the Reprimo 824G>C heterozygote and
            diverticular disease may exist on the basis of deviation from
            Hardy-Weinberg equilibrium.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Sato,N., Fukushima,N., Matsubayashi,H., Iacobuzio-Donahue,C.A.,
            Yeo,C.J. and Goggins,M.
  TITLE     Aberrant methylation of Reprimo correlates with genetic instability
            and predicts poor prognosis in pancreatic ductal adenocarcinoma
  JOURNAL   Cancer 107 (2), 251-257 (2006)
   PUBMED   16752411
  REMARK    GeneRIF: Results suggest that aberrant methylation of Reprimo is a
            common event in pancreatic carcinogenesis and is associated with
            genetic instability.
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Ye,Z. and Parry,J.M.
  TITLE     Identification of polymorphisms in the human Reprimo gene using
            public EST data
  JOURNAL   Teratog Carcinog Mutagen 22 (6), 485-493 (2002)
   PUBMED   12395409
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Ohki,R., Nemoto,J., Murasawa,H., Oda,E., Inazawa,J., Tanaka,N. and
            Taniguchi,T.
  TITLE     Reprimo, a new candidate mediator of the p53-mediated cell cycle
            arrest at the G2 phase
  JOURNAL   J Biol Chem 275 (30), 22627-22630 (2000)
   PUBMED   10930422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA452090.1 and BC002908.2.
            
            On Nov 22, 2018 this sequence version replaced NM_019845.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC002908.2, SRR7410570.209613.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325926.4/ ENSP00000314946.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AA452090.1         47-56
            11-1425             BC002908.2         1-1415
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..1425
                     /gene="RPRM"
                     /gene_synonym="REPRIMO"
                     /note="reprimo, TP53 dependent G2 arrest mediator homolog"
                     /db_xref="GeneID:56475"
                     /db_xref="HGNC:HGNC:24201"
                     /db_xref="MIM:612171"
     exon            1..1425
                     /gene="RPRM"
                     /gene_synonym="REPRIMO"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..527
                     /gene="RPRM"
                     /gene_synonym="REPRIMO"
                     /note="reprimo, TP53 dependant G2 arrest mediator
                     candidate; candidate mediator of the p53 dependent G2
                     arrest; reprimo, TP53 dependent G2 arrest mediator
                     candidate"
                     /codon_start=1
                     /product="protein reprimo"
                     /protein_id="NP_062819.1"
                     /db_xref="CCDS:CCDS2198.1"
                     /db_xref="GeneID:56475"
                     /db_xref="HGNC:HGNC:24201"
                     /db_xref="MIM:612171"
                     /translation="MNPALGNQTDVAGLFLANSSEALERAVRCCTQASVVTDDGFAEG
                     GPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVE
                     AVVVGPY"
     regulatory      1402..1407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPRM"
                     /gene_synonym="REPRIMO"
                     /note="hexamer: AATAAA"
     polyA_site      1425
                     /gene="RPRM"
                     /gene_synonym="REPRIMO"
                     /note="major polyA site"
ORIGIN      
        1 agaagagcct agctgctgcg cgcgtcggag aggctcctgg gaaactccca cggcccaggg
       61 actttcgaaa gcagagcgag gagccctcgc acgcgctagt ctgcgagtga gcgctcagcc
      121 cggcacctgt tcctccagcg ccgccgcctt cccacccctc ggacccgcgc cgctcgcggc
      181 gcccgcccgt tcctgcgatg aatccggccc taggcaacca gacggacgtg gcgggcctgt
      241 tcctggccaa cagcagcgag gcgctggagc gagccgtgcg ctgctgcacc caggcgtccg
      301 tggtgaccga cgacggcttc gcggagggag gcccggacga gcgtagcctg tacataatgc
      361 gcgtggtgca gatcgcggtc atgtgcgtgc tctcactcac cgtggtcttc ggcatcttct
      421 tcctcggctg caatctgctc atcaagtccg agggcatgat caacttcctc gtgaaggacc
      481 ggaggccgtc taaggaggtg gaggcggtgg tcgtggggcc ctactgaccc gccctctgcc
      541 cccgcggcaa ccgctcccac gcctgcccac tttgctagcc cggctgtgcc cctcactatc
      601 agagactggg cgaagcaaac ctgtcggagt caattatttc tctcgacttc ggcctttcgg
      661 aaagaagcga ccggtttctc cctcgccctc tgaaagtcct catgcctggc agtcggagga
      721 gagcgcccag actctgaact cagcagaaag tggcaagaag agggcgatta gggcgcagaa
      781 ctttggaagc tgctacttac ttggaatgcg gggagaccga cggtgcgaag gcccttctcc
      841 acccgcaggt gggccaagct ctgggggcag gtggagaggg cgggcagggg agagacccag
      901 cggcactgat cgccttgtga ccggaagagt gacctgttaa aagccacgca gcagactcat
      961 ggggtctcac aaatccgtgt ccgggtgcgc tcccactctt ctcctgctcc ccccctgccc
     1021 tggaggggag gggcgataaa tacctttgat tgtaacgtgc cgttttaaga ggttttgtgt
     1081 ttgtttgctt gaatacaaat gtttgataag tctttttctg ccccagtggc ctgtttgcct
     1141 gcctgaggag ttacagtttt gtcattgtgg gagaaggggt ggggggaggg ggagcctgcg
     1201 aatttgaacg gggtgagttg tttcttttag tgcatttccc actgggtctt ttgggaggcg
     1261 tctagcgttc ctgctggccc tgggacaaag acccagaata gaactcgtag ctcgtgactg
     1321 cacggtttac gccacaaaag tgctcttgac atccgtgaca ccgttttgac tttttgtttt
     1381 tttcttattt aacatttcct taataaatgc aacatttaag cgttt
//
