LOCUS       NM_021215               3672 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulation of nuclear pre-mRNA domain containing 1B
            (RPRD1B), mRNA.
ACCESSION   NM_021215
VERSION     NM_021215.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3672)
  AUTHORS   Jia,Y., Yan,Q., Zheng,Y., Li,L., Zhang,B., Chang,Z., Wang,Z.,
            Tang,H., Qin,Y. and Guan,X.Y.
  TITLE     Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates
            fatty acid metabolism and lymph node metastasis via
            c-Jun/c-Fos/SREBP1 axis in gastric cancer
  JOURNAL   J Exp Clin Cancer Res 41 (1), 287 (2022)
   PUBMED   36171622
  REMARK    GeneRIF: Long non-coding RNA NEAT1 mediated RPRD1B stability
            facilitates fatty acid metabolism and lymph node metastasis via
            c-Jun/c-Fos/SREBP1 axis in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3672)
  AUTHORS   Siril,Y.J., Kouketsu,A., Saito,H., Takahashi,T. and Kumamoto,H.
  TITLE     Immunohistochemical expression levels of cyclin D1 and CREPT
            reflect the course and prognosis in oral precancerous lesions and
            squamous cell carcinoma
  JOURNAL   Int J Oral Maxillofac Surg 51 (1), 27-32 (2022)
   PUBMED   33838964
  REMARK    GeneRIF: Immunohistochemical expression levels of cyclin D1 and
            CREPT reflect the course and prognosis in oral precancerous lesions
            and squamous cell carcinoma.
REFERENCE   3  (bases 1 to 3672)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3672)
  AUTHORS   Zhai,W., Ye,X., Wang,Y., Feng,Y., Wang,Y., Lin,Y., Ding,L.,
            Yang,L., Wang,X., Kuang,Y., Fu,X., Eugene Chin,Y., Jia,B., Zhu,B.,
            Ren,F. and Chang,Z.
  TITLE     CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene
            transcription in a p300-dependent manner
  JOURNAL   Br J Cancer 124 (8), 1437-1448 (2021)
   PUBMED   33531691
  REMARK    GeneRIF: CREPT/RPRD1B promotes tumorigenesis through STAT3-driven
            gene transcription in a p300-dependent manner.
REFERENCE   5  (bases 1 to 3672)
  AUTHORS   Yang,L., Yang,H., Chu,Y., Song,Y., Ding,L., Zhu,B., Zhai,W.,
            Wang,X., Kuang,Y., Ren,F., Jia,B., Wu,W., Ye,X., Wang,Y. and
            Chang,Z.
  TITLE     CREPT is required for murine stem cell maintenance during
            intestinal regeneration
  JOURNAL   Nat Commun 12 (1), 270 (2021)
   PUBMED   33431892
  REMARK    GeneRIF: CREPT is required for murine stem cell maintenance during
            intestinal regeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3672)
  AUTHORS   Wang,Y., Qiu,H., Hu,W., Li,S. and Yu,J.
  TITLE     RPRD1B promotes tumor growth by accelerating the cell cycle in
            endometrial cancer
  JOURNAL   Oncol Rep 31 (3), 1389-1395 (2014)
   PUBMED   24452636
  REMARK    GeneRIF: RPRD1B overexpression promotes tumor growth and
            accelerates cell cycle progression.
REFERENCE   7  (bases 1 to 3672)
  AUTHORS   Lu,D., Wu,Y., Wang,Y., Ren,F., Wang,D., Su,F., Zhang,Y., Yang,X.,
            Jin,G., Hao,X., He,D., Zhai,Y., Irwin,D.M., Hu,J., Sung,J.J.,
            Yu,J., Jia,B. and Chang,Z.
  TITLE     CREPT accelerates tumorigenesis by regulating the transcription of
            cell-cycle-related genes
  JOURNAL   Cancer Cell 21 (1), 92-104 (2012)
   PUBMED   22264791
  REMARK    GeneRIF: CREPT increases cyclin D1 transcription during
            tumorigenesis.
REFERENCE   8  (bases 1 to 3672)
  AUTHORS   Ni,Z., Olsen,J.B., Guo,X., Zhong,G., Ruan,E.D., Marcon,E.,
            Young,P., Guo,H., Li,J., Moffat,J., Emili,A. and Greenblatt,J.F.
  TITLE     Control of the RNA polymerase II phosphorylation state in promoter
            regions by CTD interaction domain-containing proteins RPRD1A and
            RPRD1B
  JOURNAL   Transcription 2 (5), 237-242 (2011)
   PUBMED   22231121
REFERENCE   9  (bases 1 to 3672)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 3672)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP359144.1, BC033629.1 and AK092567.1.
            
            On May 17, 2019 this sequence version replaced NM_021215.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033629.1, SRR1660805.10487.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373433.9/ ENSP00000362532.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               BP359144.1         201-465
            266-2032            BC033629.1         250-2016
            2033-2257           AK092567.1         1188-1412
            2258-2940           BC033629.1         2242-2924
            2941-3667           AK092567.1         2100-2826
            3668-3672           BC033629.1         3652-3656
FEATURES             Location/Qualifiers
     source          1..3672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..3672
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /note="regulation of nuclear pre-mRNA domain containing
                     1B"
                     /db_xref="GeneID:58490"
                     /db_xref="HGNC:HGNC:16209"
                     /db_xref="MIM:614694"
     exon            1..353
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1183
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /note="cell-cycle related and expression-elevated protein
                     in tumor; Ku70-binding protein 5-Hera"
                     /codon_start=1
                     /product="regulation of nuclear pre-mRNA domain-containing
                     protein 1B"
                     /protein_id="NP_067038.1"
                     /db_xref="CCDS:CCDS13301.1"
                     /db_xref="GeneID:58490"
                     /db_xref="HGNC:HGNC:16209"
                     /db_xref="MIM:614694"
                     /translation="MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVW
                     HRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKK
                     PLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDD
                     YPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKIT
                     DKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKL
                     EEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPLPSAGDLFSTD"
     exon            354..483
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /inference="alignment:Splign:2.1.0"
     exon            484..617
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /inference="alignment:Splign:2.1.0"
     exon            618..730
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /inference="alignment:Splign:2.1.0"
     exon            731..857
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1033
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..3672
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3649..3654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /note="hexamer: AATAAA"
     polyA_site      3672
                     /gene="RPRD1B"
                     /gene_synonym="C20orf77; CREPT; dJ1057B20.2; K-H;
                     Kub5-Hera; NET60"
                     /note="major polyA site"
ORIGIN      
        1 gtcgggtggc catcttgtgg cggcggcgcg ggcggctgtt actgcggaga cccatcccct
       61 cccccttctc gcacccctgg cagtctgtca gtcggtaaaa agtcccgcag cctgtcaggt
      121 gaggccccgg cctcgtgccg tcgctcttcc cgccgcactg ggcggcccag gccgctccct
      181 gccgggcctc actgccgcca ccatgtcctc cttctctgag tcggcgctgg agaagaagct
      241 ctcggagctg agcaactctc agcagagcgt gcagaccctg tccctttggc tcatccacca
      301 ccgcaagcac gcgggaccca tcgtctccgt gtggcaccgc gagctccgca aagccaaatc
      361 aaatagaaag cttacttttc tgtatttagc gaatgatgtc atccaaaaca gtaaaaggaa
      421 aggacctgaa ttcactagag aatttgaatc tgtccttgtg gatgcttttt ctcatgttgc
      481 cagagaggca gatgaaggct gtaaaaaacc tttagaaaga ttgctgaaca tctggcaaga
      541 acgaagtgtg tatggcggcg agttcataca gcagctgaag ctgtctatgg aggactccaa
      601 gagccctccc cccaaagcaa cagaagagaa gaaatctctg aaacgaactt ttcagcaaat
      661 tcaggaggag gaggatgacg actaccctgg cagctactct cctcaggatc cttctgcagg
      721 acccctcttg actgaggaac taatcaaagc tttgcaggat ctggaaaatg ccgcatcagg
      781 ggatgctact gtccgacaga aaattgcttc tctgccccag gaagtgcaag atgtttctct
      841 attggaaaaa ataacagaca aagaggcagc tgaacgtctt tcaaaaacag tagatgaagc
      901 atgtctgtta ctagcagaat ataacgggcg cctggcagca gaactggagg accgtcgcca
      961 gctggctcgg atgttggtgg agtataccca gaatcagaaa gatgttttgt cggagaagga
     1021 gaaaaaacta gaggaataca aacagaagct tgcacgagta acccaggtcc gcaaggaact
     1081 gaaatcccat attcagagct tgccagacct ctcactgctg cccaacgtca cagggggctt
     1141 agcccccctg ccctctgctg gggacctgtt ttcaactgac taggatgggt gtcatgtccc
     1201 agatttctgt ttgtaccagc agaaagaaga gggcaagtca tggttggaaa taaccttcta
     1261 gcccctggtt ctatcccttc ttccgcccag ccccccagcc tcaagaaaga acctcagact
     1321 ctgattctcc tcttcagcct ctcatcttga gcacagttca gaacagtggc gactggaatc
     1381 tggtttatat tcatatttgc aaagactaca gactttttct cccacttcat attttcatgc
     1441 ccccctgttg gttttccatt cttaactgtc tccttatacc taagaagtta tgaaaatcat
     1501 gtgtacttct ggaagctttc gaaagaatct tgtccctcat gacagcattt tatcatgaaa
     1561 gcagcttctc ctttctgggc tgggcttgtt caagttcggt gtgggcttcc actaaggcac
     1621 ttgtcctgga gacgttggct ttcccagctg catctgcccc aaaaggttgt aggcacagct
     1681 gtcgtagcgt tgccataaag agtttgccaa atctctgatc ctccctttcc attgcttctc
     1741 ctagtgatgc acgaagatta ggtgcattta ttttgtaaac agattggaga atctagcaat
     1801 aagattcaaa gctaatctgg agcataaagg cacagttcag agacagaata acagggatca
     1861 caagcatgaa ttaaaaggaa tttatttgct tcaagttcct agatacaacc ttcccatgct
     1921 gcacttctcc actgtcggag cacgttccga aaaacagaat gccttgatcc ctggtgggtg
     1981 cgaaggcagt tgttagggat ggcaggcatt ggtgggctcc aaaagatgaa ggccccacac
     2041 acaggtgtgc tgcatttggg atctgtgtgg gtgtttcttg gaccctttct tctgggagta
     2101 gggtacacac taacgtttaa tccgctgtct gggtgcatgt ccacagtacg gtggctaaac
     2161 tcgaacatca ctgcaaatag gacgctgagc aggtccgtct gtcatgtcac gccactgcac
     2221 aggtccttgt ccccacacga cggggagtac ttgcgtcaga tgttattgaa tagctcgtct
     2281 cgggcagggg aagcggggag ttggggatat taattggggg ttttaattct attatcatgt
     2341 cagctgacat tatgactata taatgtagtt agagacaatt tttatcttgc ttatagtaaa
     2401 ggttcagcct gccaattgta aatcattcta atttggcagg cttatttttg acattggaaa
     2461 gggcagaaag cgatttgccc cagtagtgta ataggagtta tagaccagag gctgaaaccc
     2521 aaactatata aaaaggaatt cagtggaggg ggctttgtaa tctccattaa tttgtgttgc
     2581 tacttccagg atcaccaaaa attacatgta attttacatg ttaaacacat tgaaacataa
     2641 cctatgttta taaagcataa cgggcttccc ttccagaagc tctcctgctt gtcatgaagt
     2701 gagaacaatg aaaagtcata gcagatactc agtttaactc tgtgtagaac ctagtagtgt
     2761 ttgagctgtt attcagattt gaattcagac tgtgtgttgt ttgcttatgg acactgcctg
     2821 tcgttctgtc actgttaaat taatgagtct ataaggtttt tcttccagag gccataggtg
     2881 acatcactaa aattgcaaga taaattgtaa tctttgctgc tgctgcactc cccaacctct
     2941 cccccacccc ccgtggtgtg ctgctttcta gatgagcgtg ttttggagca ggcccatctg
     3001 ggacactcta tgctttcacc aaggaagtgc gatctgagca gccacaatcc agccaaaaga
     3061 ggatcgtaga tatttgctct gatcaactag atgaaaatat agcagaatgg atttagccca
     3121 ctgctctgtt ttatccaact gagtctctga ccagcaattg gtgcataatt attacagcaa
     3181 aagttaagaa atgaaactgt agcaattatg taaatgaatg tgttggcctc ttaatacctg
     3241 ttactagtgg acttcctgtg aggaagttag ttttttgttt tgatgaaatg ctttcgtttt
     3301 ttaaatctta attctgctgt ccacatcctc ccaaagtgtg cttacttcat ttgtttaatt
     3361 taaatgaact ttcctccttg tatgtatgag gtgacttggt gggtggggtg ggtggttttt
     3421 gtttttgtgt tttttctttc ttagggcatc tgtaggcctc aaaggacctt tcctttaggt
     3481 catattcctc agaaagtctt caatcttccc ttgtttttgt ttgtttgttt ttcttaaaga
     3541 atattttcaa agcttaaatt tgtatattaa tttaggacta tttagaagta taggctgtcg
     3601 ttggcggcag cagtatattc tgaaatgtct catagatata tatttttgaa taaagatggt
     3661 gttgttgaac aa
//
