LOCUS       NM_018170               4421 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens regulation of nuclear pre-mRNA domain containing 1A
            (RPRD1A), transcript variant 1, mRNA.
ACCESSION   NM_018170
VERSION     NM_018170.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4421)
  AUTHORS   Feng,X., Jiang,T., Yang,C., Pang,S., Ding,Z., Hu,H., Wang,H.,
            Dong,L. and Yang,N.
  TITLE     RPRD1A stabilizes NRF2 and aggravates HCC progression through
            competing with p62 for TRIM21 binding
  JOURNAL   Cell Death Dis 13 (1), 6 (2021)
   PUBMED   34921137
  REMARK    GeneRIF: RPRD1A stabilizes NRF2 and aggravates HCC progression
            through competing with p62 for TRIM21 binding.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4421)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4421)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   4  (bases 1 to 4421)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4421)
  AUTHORS   Ren,L., Chen,H., Song,J., Chen,X., Lin,C., Zhang,X., Hou,N.,
            Pan,J., Zhou,Z., Wang,L., Huang,D., Yang,J., Liang,Y., Li,J.,
            Huang,H. and Jiang,L.
  TITLE     MiR-454-3p-Mediated Wnt/beta-catenin Signaling Antagonists
            Suppression Promotes Breast Cancer Metastasis
  JOURNAL   Theranostics 9 (2), 449-465 (2019)
   PUBMED   30809286
  REMARK    GeneRIF: The Wnt/beta-catenin signaling antagonist RPRD1A was
            downregulated and its upstream regulator miR-454-3p was amplified
            and overexpressed in metastatic breast cancer, and both were
            correlated with overall and relapse-free survival in breast cancer
            patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4421)
  AUTHORS   Behr,E.R., Ritchie,M.D., Tanaka,T., Kaab,S., Crawford,D.C.,
            Nicoletti,P., Floratos,A., Sinner,M.F., Kannankeril,P.J.,
            Wilde,A.A., Bezzina,C.R., Schulze-Bahr,E., Zumhagen,S.,
            Guicheney,P., Bishopric,N.H., Marshall,V., Shakir,S.,
            Dalageorgou,C., Bevan,S., Jamshidi,Y., Bastiaenen,R.,
            Myerburg,R.J., Schott,J.J., Camm,A.J., Steinbeck,G., Norris,K.,
            Altman,R.B., Tatonetti,N.P., Jeffery,S., Kubo,M., Nakamura,Y.,
            Shen,Y., George,A.L. Jr. and Roden,D.M.
  TITLE     Genome wide analysis of drug-induced torsades de pointes: lack of
            common variants with large effect sizes
  JOURNAL   PLoS One 8 (11), e78511 (2013)
   PUBMED   24223155
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4421)
  AUTHORS   Zhang,X., Cao,Q., Liu,X., Liu,S., Wang,J., Sun,S., Wang,O.,
            Tian,Z., Liu,H., Kuang,J. and Zhang,W.
  TITLE     Cellular and molecular evidence for malignancy-inhibitory functions
            of p15RS
  JOURNAL   Cell Cycle 11 (10), 1988-1998 (2012)
   PUBMED   22580456
  REMARK    GeneRIF: The p15RS expression specifically downregulates the
            expression of cathepsin B and MMP-9 at RNA levels, which are known
            to promote cell invasion through degrading extracellular matrix
            proteins.
REFERENCE   8  (bases 1 to 4421)
  AUTHORS   Ni,Z., Olsen,J.B., Guo,X., Zhong,G., Ruan,E.D., Marcon,E.,
            Young,P., Guo,H., Li,J., Moffat,J., Emili,A. and Greenblatt,J.F.
  TITLE     Control of the RNA polymerase II phosphorylation state in promoter
            regions by CTD interaction domain-containing proteins RPRD1A and
            RPRD1B
  JOURNAL   Transcription 2 (5), 237-242 (2011)
   PUBMED   22231121
REFERENCE   9  (bases 1 to 4421)
  AUTHORS   Wu,Y., Zhang,Y., Zhang,H., Yang,X., Wang,Y., Ren,F., Liu,H.,
            Zhai,Y., Jia,B., Yu,J. and Chang,Z.
  TITLE     p15RS attenuates Wnt/{beta}-catenin signaling by disrupting
            {beta}-catenin.TCF4 Interaction
  JOURNAL   J Biol Chem 285 (45), 34621-34631 (2010)
   PUBMED   20739273
  REMARK    GeneRIF: p15RS inhibits Wnt signaling by interrupting
            beta-catenin.TCF4 complex formation and that Wnt signaling
            initiates downstream gene expression by removing p15RS from
            promoters.
REFERENCE   10 (bases 1 to 4421)
  AUTHORS   Liu,J., Liu,H., Zhang,X., Gao,P., Wang,J. and Hu,Z.
  TITLE     Identification and characterization of P15RS, a novel P15(INK4b)
            related gene on G1/S progression
  JOURNAL   Biochem Biophys Res Commun 299 (5), 880-885 (2002)
   PUBMED   12470661
  REMARK    GeneRIF: molecular cloning and characterization of P15RS, a novel
            P15(INK4b) related gene involved in G1/S progression
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK001518.1, AF419845.1,
            AW409855.1 and BC000225.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018170.4.
            
            Summary: This gene encodes a cell-cycle and transcription
            regulatory protein. The encoded protein interacts with the cell
            cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may
            function as a negative regulator of G(1)/S phase progression. This
            protein also forms homo- and hetrodimers with the protein,
            regulation of nuclear pre-mRNA domain-containing protein 1B, to
            form a scaffold that interacts with the C-terminal domain of RNA
            polymerase II subunit B1 and regulates several aspects of
            transcription. Alternate splicing results in multiple transcript
            variants. A pseudogene of this gene is found on chromosome 16.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001518.1, AF419845.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399022.9/ ENSP00000381984.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AK001518.1         1-149
            150-268             AF419845.1         2-120
            269-606             AW409855.1         286-623
            607-4417            AF419845.1         459-4269
            4418-4421           BC000225.1         1942-1945
FEATURES             Location/Qualifiers
     source          1..4421
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..4421
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /note="regulation of nuclear pre-mRNA domain containing
                     1A"
                     /db_xref="GeneID:55197"
                     /db_xref="HGNC:HGNC:25560"
                     /db_xref="MIM:610347"
     exon            1..306
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1094
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulation of nuclear pre-mRNA domain-containing protein
                     1A; cyclin-dependent kinase 2B-inhibitor-related protein;
                     p15INK4B-related protein; CDKN2B-related protein;
                     Cyclin-dependent kinase inhibitor 2B-related protein
                     (p15INK4B-related protein)"
                     /codon_start=1
                     /product="regulation of nuclear pre-mRNA domain-containing
                     protein 1A isoform 1"
                     /protein_id="NP_060640.2"
                     /db_xref="CCDS:CCDS11917.1"
                     /db_xref="GeneID:55197"
                     /db_xref="HGNC:HGNC:25560"
                     /db_xref="MIM:610347"
                     /translation="MSAFSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVW
                     ERELRKAKPNRKLTFLYLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKK
                     HLGRVLSIWEERSVYENDVLEQLKQALYGDKKPRKRTYEQIKVDENENCSSLGSPSEP
                     PQTLDLVRALQDLENAASGDAAVHQRIASLPVEVQEVSLLDKITDKESGERLSKMVED
                     ACMLLADYNGRLAAEIDDRKQLTRMLADFLRCQKEALAEKEHKLEEYKRKLARVSLVR
                     KELRSRIQSLPDLSRLPNVTGSHMHLPFAGDIYSED"
     exon            307..436
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /inference="alignment:Splign:2.1.0"
     exon            437..543
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /inference="alignment:Splign:2.1.0"
     exon            544..641
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /inference="alignment:Splign:2.1.0"
     exon            642..768
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /inference="alignment:Splign:2.1.0"
     exon            769..944
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /inference="alignment:Splign:2.1.0"
     exon            945..4421
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2369..2374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /note="hexamer: AATAAA"
     polyA_site      2399
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /note="major polyA site"
     regulatory      4392..4397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
                     /note="hexamer: AATAAA"
     polyA_site      4421
                     /gene="RPRD1A"
                     /gene_synonym="HsT3101; P15RS"
ORIGIN      
        1 atcttgctgg tttgcggccg gtcttggatg aagcggcggc cgtggtgaga gcgtggggaa
       61 gggtggggtg agggggcgag gccgcagcta gggcggcgaa actctcctcc cctcggcccc
      121 accgcgtggg acggcgtgaa cgtggtgtcg gagggatgtc agccttctct gaggcggcgc
      181 tggagaagaa gctgtcggag ttgagcaact cgcagcagag cgtgcagacc ttgtccctgt
      241 ggctcattca ccaccgtaaa cactcgcgtc ccatcgtcac cgtgtgggag cgggagctgc
      301 ggaaagccaa accaaacagg aagcttactt ttctctacct agccaatgat gtcatacaga
      361 acagcaagag gaaggggcca gagtttacaa aagattttgc accagttata gtggaggctt
      421 ttaagcatgt ttcaagtgaa actgatgaaa gttgtaagaa gcaccttgga agagtgttat
      481 ctatttggga agaaaggtct gtttatgaaa atgatgtatt agaacaactt aaacaagctc
      541 tgtatggtga taagaagcct aggaagcgaa cttatgaaca gataaaggtg gatgaaaatg
      601 aaaactgttc ctctctggga tctccaagtg aaccaccaca gactctagat ctcgttagag
      661 cattacaaga tctggaaaat gcagcctcag gtgatgcagc agttcatcag aggatagctt
      721 ctttacctgt tgaagtccaa gaagtatctc tattagataa aataacagat aaagaatctg
      781 gagaaaggct ttccaaaatg gtagaggatg cgtgtatgtt gctggcagat tacaatggca
      841 gattggcggc agaaatagat gatagaaagc aactcactcg aatgttagca gattttcttc
      901 gttgtcaaaa ggaagccctt gcagagaaag agcataaatt ggaagagtac aagcgcaagc
      961 tagccagagt ttccctggtg cgcaaagaac tcaggtcccg gatccagagc ctgccagact
     1021 tatctcgatt gcccaatgtc actggcagcc acatgcacct gccctttgcg ggagacatct
     1081 acagtgaaga ttgatggacc agcctctttc caggtcccag gactttgcaa gagatggaga
     1141 caggttaggt ggatagtcct gtagtgttat ttttgtatat tgttgagaaa gaaacactaa
     1201 caaaaggaac aacgagtaat ttataaaatt gtttaaaatg ttggtttgtt tactatttta
     1261 ttggtaaatt aacatgactt aatttgaaca aagtgatgat ttgtgtgtat taataagctc
     1321 acaaatagtg attattttca aaagatcttt ttgtaaattt tttttttgat ccaaggcctt
     1381 gtgagaaatc tcttgtttgt atttcttcag gtattttcaa ttgtttttct ttattttctt
     1441 cagcatttaa tcactgtata ctatgtaatt cctgaagggg aagaactaat taggagttga
     1501 ttgagacttt attatggtat agttaggact tgattgtaga agggactaaa tgttccaaca
     1561 taatctttac ccttctcccc aaacaaaata tcaattctgt gtctctacat gcctttgatt
     1621 ccttagaggt cggtaattta acataaaaca gggatgtcac tttgaggggc agatgaaagt
     1681 ctagagaact gttccttaat agcattgtaa aagttccatt ccaactgcca gtgtagattt
     1741 taaaagtgtt aaatagtgac tcccttgatt aaactgtttg taattatttg agtagattaa
     1801 taatgaaaat actttggaaa taatatacat tttgacattc taccaagagg acaactttgg
     1861 ttctggaact ggtttctatt tgtcaaatca gtttcctttt aacataatta atccctttaa
     1921 caaaaagccg tctatgggat taaaagacac gtgaaatgat acttttatta ttcccttgct
     1981 catataactt taaaaataat acttttagct ctaatagctc aagaacacaa tattcgttaa
     2041 tgttcagtaa agtagcctga gacattttca atgtttcctt aaggtttttg aatgactgta
     2101 tatttggcag ttaagcagtg ccacactaca gggtagatat ggtaaatttt atatttgtat
     2161 atttacagtt acaaaacaaa tgtactttta ccttttattt ctgaccctgt gtgttagagc
     2221 agttgcatgc tctcctgctg ttaaaaacac attgttaagc tgtggatttg tactcaataa
     2281 tgacttagga taaacattta ttttcattca ttgctttaca tactagacat ttttcttctc
     2341 tttgtaagta gattcaaatt agatagtcaa taaaacatct tgaaaatccc acaagccaat
     2401 tatgtctctc tagtctgaat ggcttcattg tttctttctc agtattagaa attatagtta
     2461 caatgaattg catatgaaga aggcagacat ttatttttaa tagccaagta gttctgcaaa
     2521 tagttctttt aacaatttga cctctctcca aaacagagac acatataagt agtgctcatc
     2581 catgcactac taataataca tggcttattc caaagttttt agtcaacttt tgggacttgg
     2641 ggtgcatttt ctcacagaaa gaatagtagt taggttccct aacactaccg ctgatagctc
     2701 acctgggaac tgaatccacc taaccatgaa tgtccttcac ttgtaacgtg gttcacaggt
     2761 tactaatcat agatcctgac cagcatttgt aacactgctc taactaggac acagcatgca
     2821 gcagccacac tcacaccctg ggatgtctgt gtacctctgt ccctaggtgt aggaaatgga
     2881 agaaaaagat tcagccaagt ggggaggtga cagatgcaca attatgaaac ctggttgtac
     2941 atgttatgaa agtatactaa gtaagttagt ttttattatt aatgtgaaag caaaaacttg
     3001 tatgttaact tattttcaat atcttgacct tatttatgat ctgctaaagt ggtgatttat
     3061 ccattcaaaa tatatatttt tttccattta aaactaattt ataaactatg tactcctggg
     3121 aagatttgaa atcttttaga agtttgttga aatattttca ccatttcaga cagacttctg
     3181 acttagatac tgattttaat gccagtatct gctctaaata tttatgataa aaatgcatta
     3241 tttttttaaa gagcttgatg agatttgtga taagtgatag tactcaaaaa cctgaatccc
     3301 acccctcgac caatcctcca caaacttcag ttgttggtta acgtattaac tgaacacaga
     3361 caatacagtc tgatttagaa gtcatctttt cagccgtgtg ataattaaca tggtaagcct
     3421 tagcagcaaa cattcttcct aaaaggaaga cttcattttc tcaagaaatg ggattagttg
     3481 ggggtattat aataccaaat tgtaaatcat gagcgttttc tccactgtgc acctgaggca
     3541 gatcatgcat ctttgagtgc agtttggtct gacccctcaa gagaaaagca tggtgccgta
     3601 gggctgctat ggtttgaatg gatgccatca ctcttttctc cacatacagt gcagagagct
     3661 gtctggagtc acaatctgaa cagattctcg ggcgctcctt ctctccttcc atcactacag
     3721 taagtaaaag gaccatagag gggaaccagg aatctgagaa tcagctgtgc tcaatagcca
     3781 acctccctgt ccagatgcag ctattttggt atctcctatc acatgcactc tgaatcaggg
     3841 tttttctata agaaatcttt cagaatcagc aaaagtgggg atgacccagg catcttgatt
     3901 tgcaaaatca caaaactaag ttgtcagtta tcactgtaga tgagcaactc atctttttaa
     3961 agtatagtta ctgaactgat tctgagaaat ctttagagag aaaaaactca acagtacaaa
     4021 ttaactaatt gggaaagtta gaatgtcctt tctgaatttt tcattaaaaa aattacatta
     4081 tctgaaataa cataaagcta ctaaactgct ttgtattcta ttaagaaata gctcctaagg
     4141 atgtagtctt gtttcatagt tgttgcacta tatcaaaact taaaatgtaa gcccagttct
     4201 tctctgtata gaaaggaaac attgtgttac ttaatgaatt atttatacag agcatttgtt
     4261 gccaactgtt gttccagcca tccacacagg agtctgttct gaggtggcaa tagcacatgg
     4321 gaagatgaac tttccctgtt tgtttacccg ttcttctttg gctgtatctg atgacagtat
     4381 aagatgttct taataaagtt ttatgttctt tttgaaatgt g
//
