LOCUS       NM_006638               1488 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ribonuclease P/MRP subunit p40 (RPP40), transcript
            variant 1, mRNA.
ACCESSION   NM_006638
VERSION     NM_006638.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1488)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1488)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1488)
  AUTHORS   Wu,J., Niu,S., Tan,M., Huang,C., Li,M., Song,Y., Wang,Q., Chen,J.,
            Shi,S., Lan,P. and Lei,M.
  TITLE     Cryo-EM Structure of the Human Ribonuclease P Holoenzyme
  JOURNAL   Cell 175 (5), 1393-1404 (2018)
   PUBMED   30454648
REFERENCE   4  (bases 1 to 1488)
  AUTHORS   Mattijssen,S., Hinson,E.R., Onnekink,C., Hermanns,P., Zabel,B.,
            Cresswell,P. and Pruijn,G.J.
  TITLE     Viperin mRNA is a novel target for the human RNase MRP/RNase P
            endoribonuclease
  JOURNAL   Cell Mol Life Sci 68 (14), 2469-2480 (2011)
   PUBMED   21053045
  REMARK    GeneRIF: Data idenified two cleavage sites for RNase MRP/RNase P in
            the coding sequence of viperin mRNA.
REFERENCE   5  (bases 1 to 1488)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 1488)
  AUTHORS   Welting,T.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Mutual interactions between subunits of the human RNase MRP
            ribonucleoprotein complex
  JOURNAL   Nucleic Acids Res 32 (7), 2138-2146 (2004)
   PUBMED   15096576
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1488)
  AUTHORS   Jarrous,N., Eder,P.S., Guerrier-Takada,C., Hoog,C. and Altman,S.
  TITLE     Autoantigenic properties of some protein subunits of catalytically
            active complexes of human ribonuclease P
  JOURNAL   RNA 4 (4), 407-417 (1998)
   PUBMED   9630247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX951376.1, BQ220155.1, BC017871.1, BU607286.1 and AL359643.27.
            
            On May 17, 2019 this sequence version replaced NM_006638.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.333008.1,
                                           SRR7410570.258517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380051.7/ ENSP00000369391.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BX951376.1         27-52
            27-794              BQ220155.1         1-768
            795-1015            BC017871.1         726-946
            1016-1159           BU607286.1         16-159              c
            1160-1488           AL359643.27        100709-101037       c
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.1"
     gene            1..1488
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /note="ribonuclease P/MRP subunit p40"
                     /db_xref="GeneID:10799"
                     /db_xref="HGNC:HGNC:20992"
                     /db_xref="MIM:606117"
     exon            1..158
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1127
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /EC_number="3.1.26.5"
                     /note="isoform a is encoded by transcript variant 1;
                     ribonuclease P (40 kD); ribonuclease P, 40kD subunit;
                     ribonuclease P1; ribonuclease P protein subunit p40; RNase
                     P subunit 1; RNaseP protein p40; ribonuclease P/MRP 40kDa
                     subunit"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p40 isoform a"
                     /protein_id="NP_006629.2"
                     /db_xref="CCDS:CCDS34333.1"
                     /db_xref="GeneID:10799"
                     /db_xref="HGNC:HGNC:20992"
                     /db_xref="MIM:606117"
                     /translation="MATLRRLREAPRHLLVCEKSNFGNHKSRHRHLVQTHYYNYRVSF
                     LIPECGILSEELKNLVMNTGPYYFVKNLPLHELITPEFISTFIKKGSCYALTYNTHID
                     EDNTVALLPNGKLILSLDKDTYEETGLQGHPSQFSGRKIMKFIVSIDLMELSLNLDSK
                     KYERISWSFKEKKPLKFDFLLAWHKTGSEESTMMSYFSKYQIQEHQPKVALSTLRDLQ
                     CPVLQSSELEGTPEVSCRALELFDWLGAVFSNVDLNNEPNNFISTYCCPEPSTVVAKA
                     YLCTITGFILPEKICLLLEHLCHYFDEPKLAPWVTLSVQGFADSPVSWEKNEHGFRKG
                     GEHLYNFVIFNNQDYWLQMAVGANDHCPP"
     exon            159..303
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..372
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..468
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..594
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..793
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..928
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1488
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1130..1135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /note="hexamer: AATAAA"
     polyA_site      1159
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /note="major polyA site"
     regulatory      1472..1477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
                     /note="hexamer: AAGAAA"
     polyA_site      1488
                     /gene="RPP40"
                     /gene_synonym="bA428J1.3; RNASEP1"
ORIGIN      
        1 agcggaggcc gggaggacca ggaacccagg agagcatggc cacgctgcgc cggcttcggg
       61 aggcgccgcg gcacttactg gtttgcgaga aatccaactt cggcaaccac aagtcgcgcc
      121 accggcatct tgtgcagacg cactactata actacagggt ttcatttctc attcctgaat
      181 gtgggatact atcggaagaa ctgaaaaacc tggtcatgaa cactggaccc tattactttg
      241 tgaagaattt acctcttcat gaattaatta cacctgaatt catcagtacc tttataaaga
      301 aaggttcttg ctatgcacta acatacaata cacatattga tgaagataat actgttgccc
      361 tgctaccaaa tgggaaatta attttgtcac tggataaaga cacttatgaa gaaactggac
      421 ttcagggtca tccatctcag ttttctggca gaaaaattat gaaatttatt gtttccattg
      481 atttgatgga attatcctta aacttggatt ctaagaagta tgaaagaata tcttggtctt
      541 tcaaagaaaa gaagccattg aaatttgatt ttcttttggc ttggcataaa acaggttcag
      601 aagaatcgac aatgatgtca tatttttcca agtaccaaat tcaggagcat cagccaaaag
      661 tagcactgag cacgttgaga gatctccagt gcccagtgct gcagagcagc gagctggagg
      721 gaacgccaga ggtgtcctgc cgggctctgg agctcttcga ctggctcggc gccgtcttca
      781 gtaatgtcga cctaaataat gagcctaata atttcatatc aacctattgc tgtcctgagc
      841 caagcacagt ggtggcaaaa gcttatttgt gtacaatcac tggcttcata cttccagaga
      901 agatctgtct cctattggaa catctctgtc actactttga tgaaccgaag ttagctccat
      961 gggttacact gtccgttcaa ggctttgcag acagccctgt ttcttgggaa aaaaatgaac
     1021 atggttttcg aaaaggagga gaacatttat ataactttgt gatttttaat aatcaggact
     1081 attggcttca gatggctgtt ggggcaaatg atcactgtcc accataaaaa ataaaaatta
     1141 aaaatcgtgt ttacttacat ttacgcttgc tttcagattt cttaatggta aaaggtctgt
     1201 gtgtccactc aggcttgtgt gatggtgaca tttctcagat cagcatttgc tggcatcctg
     1261 ccctgcacct gagacccatc tgtgatggca gcaaggcctg ctgtccagtg aatagctcat
     1321 agttgatttc tctctgtcaa cataagcaca gggttgtggg ttactatgtg gtacactggg
     1381 ccaggatgtc cagggaccgg ggatattggt ccccatctca ctccattggt tgagatatat
     1441 tttgttcatt acaacttttt cagataataa aaagaaatct catcctta
//
