LOCUS       NM_183005               1484 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ribonuclease P/MRP subunit p38 (RPP38), transcript
            variant 1, mRNA.
ACCESSION   NM_183005
VERSION     NM_183005.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1484)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1484)
  AUTHORS   Wu,J., Niu,S., Tan,M., Huang,C., Li,M., Song,Y., Wang,Q., Chen,J.,
            Shi,S., Lan,P. and Lei,M.
  TITLE     Cryo-EM Structure of the Human Ribonuclease P Holoenzyme
  JOURNAL   Cell 175 (5), 1393-1404 (2018)
   PUBMED   30454648
REFERENCE   3  (bases 1 to 1484)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1484)
  AUTHORS   Oshima,K., Kakiuchi,Y., Tanaka,Y., Ueda,T., Nakashima,T., Kimura,M.
            and Yao,M.
  TITLE     Structural basis for recognition of a kink-turn motif by an
            archaeal homologue of human RNase P protein Rpp38
  JOURNAL   Biochem Biophys Res Commun 474 (3), 541-546 (2016)
   PUBMED   27114305
  REMARK    GeneRIF: A pull-down assay further suggested the presence of a
            second K-turn in SL12. Based on the present results, together with
            available data, we discuss a structural basis for recognition of
            K-turn motifs in PhopRNA by PhoRpp38.
REFERENCE   5  (bases 1 to 1484)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1484)
  AUTHORS   Welting,T.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Mutual interactions between subunits of the human RNase MRP
            ribonucleoprotein complex
  JOURNAL   Nucleic Acids Res 32 (7), 2138-2146 (2004)
   PUBMED   15096576
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1484)
  AUTHORS   Jiang,T., Guerrier-Takada,C. and Altman,S.
  TITLE     Protein-RNA interactions in the subunits of human nuclear RNase P
  JOURNAL   RNA 7 (7), 937-941 (2001)
   PUBMED   11455963
REFERENCE   8  (bases 1 to 1484)
  AUTHORS   Jarrous,N., Wolenski,J.S., Wesolowski,D., Lee,C. and Altman,S.
  TITLE     Localization in the nucleolus and coiled bodies of protein subunits
            of the ribonucleoprotein ribonuclease P
  JOURNAL   J Cell Biol 146 (3), 559-572 (1999)
   PUBMED   10444065
REFERENCE   9  (bases 1 to 1484)
  AUTHORS   Jarrous,N., Eder,P.S., Guerrier-Takada,C., Hoog,C. and Altman,S.
  TITLE     Autoantigenic properties of some protein subunits of catalytically
            active complexes of human ribonuclease P
  JOURNAL   RNA 4 (4), 407-417 (1998)
   PUBMED   9630247
REFERENCE   10 (bases 1 to 1484)
  AUTHORS   Eder,P.S., Kekuda,R., Stolc,V. and Altman,S.
  TITLE     Characterization of two scleroderma autoimmune antigens that
            copurify with human ribonuclease P
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1101-1106 (1997)
   PUBMED   9037013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU197354.1, BC029494.1 and AW292674.1.
            
            On Nov 22, 2018 this sequence version replaced NM_183005.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.321165.1,
                                           SRR3476690.653616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378197.5/ ENSP00000367439.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BU197354.1         199-246
            49-1475             BC029494.1         5-1431
            1476-1484           AW292674.1         15-23               c
FEATURES             Location/Qualifiers
     source          1..1484
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..1484
                     /gene="RPP38"
                     /note="ribonuclease P/MRP subunit p38"
                     /db_xref="GeneID:10557"
                     /db_xref="HGNC:HGNC:30329"
                     /db_xref="MIM:606116"
     exon            1..412
                     /gene="RPP38"
                     /inference="alignment:Splign:2.1.0"
     exon            413..531
                     /gene="RPP38"
                     /inference="alignment:Splign:2.1.0"
     exon            532..1484
                     /gene="RPP38"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..1393
                     /gene="RPP38"
                     /EC_number="3.1.26.5"
                     /note="RNaseP protein p38; ribonuclease P/MRP 38kDa
                     subunit"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p38"
                     /protein_id="NP_892117.1"
                     /db_xref="CCDS:CCDS7108.1"
                     /db_xref="GeneID:10557"
                     /db_xref="HGNC:HGNC:30329"
                     /db_xref="MIM:606116"
                     /translation="MAAAPQAPGRGSLRKTRPLVVKTSLNNPYIIRWSALESEDMHFI
                     LQTLEDRLKAIGLQKIEDKKKKNKTPFLKKESREKCSIAVDISENLKEKKTDAKQQVS
                     GWTPAHVRKQLAIGVNEVTRALERRELLLVLVCKSVKPAMITSHLIQLSLSRSVPACQ
                     VPRLSERIAPVIGLKCVLALAFKKNTTDFVDEVRAIIPRVPSLSVPWLQDRIEDSGEN
                     LETEPLESQDRELLDTSFEDLSKPKRKLADGRQASVTLQPLKIKKLIPNPNKIRKPPK
                     SKKATPK"
     regulatory      1459..1464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPP38"
                     /note="hexamer: AATAAA"
     polyA_site      1484
                     /gene="RPP38"
                     /note="major polyA site"
ORIGIN      
        1 gggcgccggt gctgttgcct tcaggtgacc acggattcgc catcgtgagt tccaggtggg
       61 cgcgcggggc ccacgtaggg caggaggcca gccccggggg gatcgggccc gggactctgc
      121 ggaatctgga ggccgaagcc cgcgcgcacg cagggtctct gctgcttccc caacgcctgt
      181 tgcgtggccg caggacccgc cgccctcccg gttgggccgc ccagtcccgg gccgggcgcg
      241 tgcacccaga gcttccgcgt ttctagtccg gctcctctgc tggattgcag cgccggctgg
      301 gcaccaggag tacaaagcga aaacccccgc cggcccttct gttctccacg gtctccaagg
      361 agacacggac aacagaacaa cacttccgtg tgctaaatag taaagcacca agacagggtc
      421 agatgtgtta ctgggctgga gtgtggtggc acaatcacgc tcactgcatc cttgacctcc
      481 tgggctcaag tgatcttccc acctcagcct cccaagtagc tgggactaca ggattttcaa
      541 aatggctgca gctcctcaag caccggggcg gggatctctc cgtaagacga gacctctggt
      601 tgtgaagacg tcgttgaaca acccatacat catccgctgg agcgctctgg agagcgagga
      661 tatgcacttc atcctacaga cgcttgagga caggcttaaa gctattggac ttcagaagat
      721 tgaagataag aagaaaaaga acaaaacacc ttttctgaaa aaagaaagca gagagaaatg
      781 cagcattgct gttgatatta gtgagaatct gaaggagaag aaaacagatg ctaagcagca
      841 agtgtcaggg tggacgcctg cacacgtcag gaagcagctt gccattggcg ttaacgaagt
      901 taccagagcc ctggaaagga gggaactgct gttagttctg gtgtgtaaat cagtcaagcc
      961 tgccatgatc acctcacact tgattcagtt aagcctaagc agaagtgtcc ctgcctgtca
     1021 ggtcccccgg ctcagtgaga gaatcgcccc cgtcattggc ttaaaatgtg ttctagcctt
     1081 ggcgttcaaa aagaacacca ctgactttgt ggacgaagta agagccatca tccccagagt
     1141 ccccagttta agtgtaccat ggcttcaaga cagaattgaa gattctgggg aaaatttaga
     1201 gactgaacct ctggaaagcc aagacagaga gcttttggac acttcatttg aagatctgtc
     1261 aaaacctaag agaaagcttg ctgacggtcg gcaggcttct gtaacattac aaccccttaa
     1321 aataaagaaa ctgattccaa accctaataa gataaggaaa ccacccaaaa gtaaaaaagc
     1381 tactccaaag taatcttgca taaacttgtc atgtcataca gtttgtgaaa ggacaccttg
     1441 taaagaagcc ttgaaactaa taaaatgagt tatacttaca taga
//
