LOCUS       NM_148178                872 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribonuclease P/MRP subunit p25 like (RPP25L),
            transcript variant 1, mRNA.
ACCESSION   NM_148178
VERSION     NM_148178.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 872)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 872)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 872)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 872)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   6  (bases 1 to 872)
  AUTHORS   Rosenblad,M.A., Lopez,M.D., Piccinelli,P. and Samuelsson,T.
  TITLE     Inventory and analysis of the protein subunits of the ribonucleases
            P and MRP provides further evidence of homology between the yeast
            and human enzymes
  JOURNAL   Nucleic Acids Res 34 (18), 5145-5156 (2006)
   PUBMED   16998185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL528391.3 and BC032136.2.
            
            On Nov 22, 2018 this sequence version replaced NM_148178.2.
            
            Summary: This gene encodes a protein that appears to belong to a
            family of evolutionarily related proteins (DUF78), that may share
            one or more domains in common. Members of this family are small
            archaebacterial proteins with no known function. Alternative
            splicing has been observed at this locus and two variants, both
            encoding the same protein, have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.120323.1, AL528391.3
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378959.9/ ENSP00000368242.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL528391.3         17-34
            19-872              BC032136.2         1-854
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..872
                     /gene="RPP25L"
                     /gene_synonym="bA296L22.5; C9orf23"
                     /note="ribonuclease P/MRP subunit p25 like"
                     /db_xref="GeneID:138716"
                     /db_xref="HGNC:HGNC:19909"
     exon            1..34
                     /gene="RPP25L"
                     /gene_synonym="bA296L22.5; C9orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            35..872
                     /gene="RPP25L"
                     /gene_synonym="bA296L22.5; C9orf23"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..562
                     /gene="RPP25L"
                     /gene_synonym="bA296L22.5; C9orf23"
                     /note="alba-like protein C9orf23; rpp25-like protein;
                     RNase P protein subunit-like p25; ribonuclease P/MRP 25kDa
                     subunit-like"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p25-like protein"
                     /protein_id="NP_680544.1"
                     /db_xref="CCDS:CCDS6559.1"
                     /db_xref="GeneID:138716"
                     /db_xref="HGNC:HGNC:19909"
                     /translation="MEHYRKAGSVELPAPSPMPQLPPDTLEMRVRDGSKIRNLLGLAL
                     GRLEGGSARHVVFSGSGRAAGKAVSCAEIVKRRVPGLHQLTKLRFLQTEDSWVPASPD
                     TGLDPLTVRRHVPAVWVLLSRDPLDPNECGYQPPGAPPGLGSMPSSSCGPRSRRRARD
                     TRS"
     regulatory      851..856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPP25L"
                     /gene_synonym="bA296L22.5; C9orf23"
                     /note="hexamer: AATAAA"
     polyA_site      872
                     /gene="RPP25L"
                     /gene_synonym="bA296L22.5; C9orf23"
                     /note="major polyA site"
ORIGIN      
        1 atcttggctc cggatcgtgc gtgaggcggc ttcgtgggca gcgagagtca cagacaagac
       61 agcaagcagg atggagcact accggaaagc tggctctgta gagctcccag cgccttcccc
      121 aatgccccag ctacctcctg atacccttga gatgcgggtc cgagatggca gcaaaattcg
      181 caacctgctg gggttggctc tgggtcggtt ggagggcggc agtgctcggc atgtagtgtt
      241 ctcaggttct ggcagggctg caggaaaggc tgtcagctgc gctgagattg tcaagcggcg
      301 ggtcccaggc ctgcaccagc tcaccaagct acgtttcctt cagactgagg acagctgggt
      361 cccagcctca cctgacacag ggctagaccc cctcacagtg cgccgccatg tgcctgcagt
      421 gtgggtgctg ctcagccggg accccctgga ccccaatgag tgtggttacc aacccccagg
      481 agcaccccct ggcctgggtt ccatgcccag ctccagctgt ggccctcgtt cccgaagaag
      541 ggctcgagac acccgatcgt gaagacctgc tgagccagcc tgttctccgg gcctgaatgt
      601 ctggggtgct tgtgcctttt ctgagaagcg ttgtgactgc tcaacatccc catcaaggtt
      661 tgagtccaca aaagtggacc tccctatcat gcttcccctt ccctctagca tgtgggaagg
      721 gactgctgtg aagaatgaca gatgtggggc ctctgccaag ttctgcattg ctaaataagg
      781 gcttcctctg ccttctacct acagtgcatt tgaactgcct tctgaaagag gtccagggag
      841 ggatttagga aataaagttt ctacctattt ga
//
