LOCUS       NM_017793               2355 bp    mRNA    linear   PRI 09-MAR-2025
DEFINITION  Homo sapiens ribonuclease P/MRP subunit p25 (RPP25), mRNA.
ACCESSION   NM_017793
VERSION     NM_017793.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Yin,C., Bai,G., Zhang,Y. and Huang,J.
  TITLE     Crystal structure of human RPP20-RPP25 proteins in complex with the
            P3 domain of lncRNA RMRP
  JOURNAL   J Struct Biol 213 (2), 107704 (2021)
   PUBMED   33571640
  REMARK    GeneRIF: Crystal structure of human RPP20-RPP25 proteins in complex
            with the P3 domain of lncRNA RMRP.
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Yang,J., Hou,S. and Liang,B.
  TITLE     LINC00319 promotes migration, invasion and epithelial-mesenchymal
            transition process in cervical cancer by regulating
            miR-3127-5p/RPP25 axis
  JOURNAL   In Vitro Cell Dev Biol Anim 56 (2), 145-153 (2020)
   PUBMED   31942724
  REMARK    GeneRIF: LINC00319 promotes migration, invasion and
            epithelial-mesenchymal transition process in cervical cancer by
            regulating miR-3127-5p/RPP25 axis.
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Huang,H.S., Cheung,I. and Akbarian,S.
  TITLE     RPP25 is developmentally regulated in prefrontal cortex and
            expressed at decreased levels in autism spectrum disorder
  JOURNAL   Autism Res 3 (4), 153-161 (2010)
   PUBMED   20632321
  REMARK    GeneRIF: Taken together, these findings suggest a potential role
            for the RPP25 gene transcript in the neurobiology of developmental
            brain disorders.
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Hands-Taylor,K.L., Martino,L., Tata,R., Babon,J.J., Bui,T.T.,
            Drake,A.F., Beavil,R.L., Pruijn,G.J., Brown,P.R. and Conte,M.R.
  TITLE     Heterodimerization of the human RNase P/MRP subunits Rpp20 and
            Rpp25 is a prerequisite for interaction with the P3 arm of RNase
            MRP RNA
  JOURNAL   Nucleic Acids Res 38 (12), 4052-4066 (2010)
   PUBMED   20215441
  REMARK    GeneRIF: analyses of interactions with deletion mutant proteins
            indicate that the Alba-type core domain of both Rpp20 and Rpp25
            contains most of the determinants for mutual association and P3 RNA
            recognition.
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Welting,T.J., Kikkert,B.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Differential association of protein subunits with the human RNase
            MRP and RNase P complexes
  JOURNAL   RNA 12 (7), 1373-1382 (2006)
   PUBMED   16723659
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Welting,T.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Mutual interactions between subunits of the human RNase MRP
            ribonucleoprotein complex
  JOURNAL   Nucleic Acids Res 32 (7), 2138-2146 (2004)
   PUBMED   15096576
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Guerrier-Takada,C., Eder,P.S., Gopalan,V. and Altman,S.
  TITLE     Purification and characterization of Rpp25, an RNA-binding protein
            subunit of human ribonuclease P
  JOURNAL   RNA 8 (3), 290-295 (2002)
   PUBMED   12003489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015720.20.
            
            On Aug 6, 2019 this sequence version replaced NM_017793.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660805.71097.1, SRR6380199.117351.9
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322177.6/ ENSP00000317691.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2355              AC015720.20        26349-28703         c
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..2355
                     /gene="RPP25"
                     /note="ribonuclease P/MRP subunit p25"
                     /db_xref="GeneID:54913"
                     /db_xref="HGNC:HGNC:30361"
                     /db_xref="MIM:619235"
     exon            1..2355
                     /gene="RPP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..789
                     /gene="RPP25"
                     /EC_number="3.1.26.5"
                     /note="RNase P protein subunit p25; ribonuclease P 25kDa
                     subunit; ribonuclease P/MRP 25kDa subunit; ribonuclease P
                     and MRP subunit p25"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p25"
                     /protein_id="NP_060263.2"
                     /db_xref="CCDS:CCDS10274.1"
                     /db_xref="GeneID:54913"
                     /db_xref="HGNC:HGNC:30361"
                     /db_xref="MIM:619235"
                     /translation="MENFRKVRSEEAPAGCGAEGGGPGSGPFADLAPGAVHMRVKEGS
                     KIRNLMAFATASMAQPATRAIVFSGCGRATTKTVTCAEILKRRLAGLHQVTRLRYRSV
                     REVWQSLPPGPTQGQTPGEPAASLSVLKNVPGLAILLSKDALDPRQPGYQPPNPHPGP
                     SSPPAAPASKRSLGEPAAGEGSAKRSQPEPGVADEDQTA"
     regulatory      1450..1455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPP25"
                     /note="hexamer: AATAAA"
     polyA_site      1468
                     /gene="RPP25"
                     /note="major polyA site"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPP25"
                     /note="hexamer: AATAAA"
     polyA_site      2355
                     /gene="RPP25"
                     /note="major polyA site"
ORIGIN      
        1 gctgagtaga gcggcgcccg ctcgagagaa gtggggccga gatcgcgccg tcccagcccg
       61 cccgccggcg tctgcgctgc tccggcgccc ttacccctgc tggcccttgc aaggcgcgac
      121 cggcggccat gcagccccgg ggctgaggcc gccccatggc aaagccggcg gtcccggcga
      181 cgacggcgca tggagaactt ccgtaaggtg cgctccgaag aggcgccagc ggggtgcggg
      241 gccgagggag gcggcccggg ctccggcccc ttcgcagacc tggcgccggg cgcggtgcac
      301 atgcgggtca aggaaggcag caagatccgg aacctgatgg ccttcgccac cgccagcatg
      361 gcgcagccag ccacgcgcgc catcgtcttc agcggctgcg gccgggccac caccaaaacc
      421 gtcacgtgcg ccgagatcct caagcgccgc ctggcgggcc tgcaccaggt cacgcggctg
      481 cgctaccgga gcgtacgcga ggtgtggcag agcctcccgc ctgggcccac gcagggtcag
      541 acgcctggcg agccggccgc tagtctcagc gtacttaaga acgtgcccgg cctcgccatc
      601 ctactttcca aggacgcgct ggatccgcga cagcccggct accagccccc gaatccccat
      661 cctggtccct cgtccccgcc agccgcgcca gcgtccaaga ggagcctagg ggaacccgca
      721 gctggagaag gctccgcgaa gcgatcgcaa cccgagccag gggttgcgga cgaggatcag
      781 acggcctgaa actccggact gtgggccacc tagtccggca ggatcttccg ccagcgcctc
      841 caccttcaga tgtacctcca gcctttcact cctcggtcct ccggagccca caacctggac
      901 acagctcctc aagacaggta gcatggacct taaggcgaca agagaggggc cccaggagtg
      961 gcaggagagg atccccgacc accctaggga aacttcgtgc gataattgct gcttatgccc
     1021 gtgttgcgtg aagacacgga acttcacctt ttctgggacc ttctttgggg gagaatggtg
     1081 gacagtggga ttctggaaac ttgtttggga cccccaaggg ttaaagccac ccagcattca
     1141 cgaagagcac ctgaagtatg gaagctgaga agagttattg gaatcacccc caccgttgac
     1201 agaggaaggc agggggtgag aattaactgc ttgagggtag gagagtctga gatgtggggg
     1261 ccctattccg ctccccgccc tgggacagtt ttcctttcta gttttctttc ccctgcttca
     1321 gaggagcatc tctgagggtt ctagctcttt taacacccct tttccccctg ctggcccaga
     1381 gggagaccca ggactgaact ctccaggcct cctcccctga gccctgcagc tggctggagt
     1441 cttgcttcca ataaaacaag cacaaaaatg gctgtgtccc ccattttttt tctaaccacc
     1501 cgcctgtgca gagacagctc tcgcctggcc ccttgtgtct cccctcccct ccagccttgc
     1561 gtcctgagtc tttggagtct tcagggtcag gcacagagac tgaacagctt caaaatggtg
     1621 caaggcactg cccagtccct ggcttcttcc tctctcctcc cccactccgc cctcccgggc
     1681 tggccctggc ctcagaggct gttgcaaatg ggggcccgtg tacccctgta catcgccact
     1741 aagggaaagg gagcggcaca ttgtttttct gggaggggaa ggaaggagtg gaaggacagc
     1801 atcgatgaac tctcctggag gtcactgcaa agggtggcag accctgctga ggtccctgaa
     1861 tctgcagcct ccagacaata aactgaacct tacccagaag gctggcacaa agcccccagc
     1921 tctgtgggta ggatctcccc ttcactgccc tctctctgag aaaggacagc acacccttgg
     1981 gaaaggggga ggagagagac tgagcacaaa tccactgctg gaaattacta ttcagcagag
     2041 aagctgggtc ttgggctgtg aatcactgca ggcctcctga taagctgctg cctccagccc
     2101 tgcacagctg tctgttgaga gataacagcc tcataagctt ctctgcccaa ctccaagcca
     2161 gctggggggt gggggtgctg ctgtgtgctg gaagagctct ggtgagttgg gggtggcata
     2221 cagccccagg atctcagaag cagatctcat cccatgcaac tcagcagcac ccctggaaag
     2281 ggggagatgc ggaagaatgt atttataagt cattttgctg gcagaaccct gaaataaatc
     2341 ctgctggtga caaga
//
