LOCUS       NM_007042               3266 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ribonuclease P/MRP subunit p14 (RPP14), transcript
            variant 2, mRNA.
ACCESSION   NM_007042
VERSION     NM_007042.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3266)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3266)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3266)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3266)
  AUTHORS   Wu,J., Niu,S., Tan,M., Huang,C., Li,M., Song,Y., Wang,Q., Chen,J.,
            Shi,S., Lan,P. and Lei,M.
  TITLE     Cryo-EM Structure of the Human Ribonuclease P Holoenzyme
  JOURNAL   Cell 175 (5), 1393-1404 (2018)
   PUBMED   30454648
REFERENCE   5  (bases 1 to 3266)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3266)
  AUTHORS   Autio,K.J., Kastaniotis,A.J., Pospiech,H., Miinalainen,I.J.,
            Schonauer,M.S., Dieckmann,C.L. and Hiltunen,J.K.
  TITLE     An ancient genetic link between vertebrate mitochondrial fatty acid
            synthesis and RNA processing
  JOURNAL   FASEB J 22 (2), 569-578 (2008)
   PUBMED   17898086
REFERENCE   7  (bases 1 to 3266)
  AUTHORS   Jiang,T., Guerrier-Takada,C. and Altman,S.
  TITLE     Protein-RNA interactions in the subunits of human nuclear RNase P
  JOURNAL   RNA 7 (7), 937-941 (2001)
   PUBMED   11455963
REFERENCE   8  (bases 1 to 3266)
  AUTHORS   Jiang,T. and Altman,S.
  TITLE     Protein-protein interactions with subunits of human nuclear RNase P
  JOURNAL   Proc Natl Acad Sci U S A 98 (3), 920-925 (2001)
   PUBMED   11158571
REFERENCE   9  (bases 1 to 3266)
  AUTHORS   Jarrous,N., Wolenski,J.S., Wesolowski,D., Lee,C. and Altman,S.
  TITLE     Localization in the nucleolus and coiled bodies of protein subunits
            of the ribonucleoprotein ribonuclease P
  JOURNAL   J Cell Biol 146 (3), 559-572 (1999)
   PUBMED   10444065
REFERENCE   10 (bases 1 to 3266)
  AUTHORS   Jarrous,N., Eder,P.S., Wesolowski,D. and Altman,S.
  TITLE     Rpp14 and Rpp29, two protein subunits of human ribonuclease P
  JOURNAL   RNA 5 (2), 153-157 (1999)
   PUBMED   10024167
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC360931.1, BC002441.1 and
            AC098479.2.
            
            On May 20, 2020 this sequence version replaced NM_007042.5.
            
            Summary: This gene encodes a subunit of ribonuclease P and has 3'
            to 5' exoribonuclease activity. Transcripts for this gene are
            bicistronic and include a conserved downstream open reading frame
            for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene.
            [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.19467.1,
                                           SRR14038193.4160652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295959.10/ ENSP00000295959.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                DC360931.1         1-61
            62-1589             BC002441.1         10-1537
            1590-3266           AC098479.2         130082-131758
FEATURES             Location/Qualifiers
     source          1..3266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..3266
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /note="ribonuclease P/MRP subunit p14"
                     /db_xref="GeneID:11102"
                     /db_xref="HGNC:HGNC:30327"
                     /db_xref="MIM:606112"
     exon            1..173
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /inference="alignment:Splign:2.1.0"
     exon            174..271
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..569
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /EC_number="3.1.26.5"
                     /note="ribonuclease P/MRP 14kDa subunit"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p14"
                     /protein_id="NP_008973.1"
                     /db_xref="CCDS:CCDS2888.1"
                     /db_xref="GeneID:11102"
                     /db_xref="HGNC:HGNC:30327"
                     /db_xref="MIM:606112"
                     /translation="MPAPAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQLL
                     ISAVKDLFGEVDAALPLDILTYEEKTLSAILRICSSGLVKLWSSLTLLGSYKGKKCAF
                     RVIQVSPFLLALSGNSRELVLD"
     exon            272..356
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /inference="alignment:Splign:2.1.0"
     exon            357..433
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /inference="alignment:Splign:2.1.0"
     exon            434..512
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /inference="alignment:Splign:2.1.0"
     exon            513..3266
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2241..2246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /note="hexamer: AATGAA"
     polyA_site      2261
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /note="major polyA site"
     regulatory      3240..3245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /note="hexamer: AATAAT"
     polyA_site      3266
                     /gene="RPP14"
                     /gene_synonym="P14"
                     /note="major polyA site"
ORIGIN      
        1 atatccgcct gggcgtcacg cttcgtgggg cgggacgagg agaagccaaa cgtaaagaca
       61 ccaggagttt ctcgggccca gctgtggctg ctgccgggga gccccaagcc ttggcgggtc
      121 cttgcggcga ataggagtct ggtcaggcgt caggctagtc cgacgaagag tgggtgtgat
      181 cagcactgga aaagatgcct gcccctgctg ccacatatga aagagtagtt tacaaaaacc
      241 cttccgagta ccactacatg aaagtctgcc tagaatttca agattgtgga gttggactga
      301 atgctgcaca gttcaaacag ctgcttattt cggctgtgaa ggacctgttt ggggaggttg
      361 atgccgcctt acctttggac atcctaacct atgaagagaa gaccttgtca gccatcttga
      421 gaatatgtag cagtggtctt gtcaaattgt ggagctcttt gaccctgtta ggatcctata
      481 aaggcaaaaa atgtgctttc cgggtgattc aggtttctcc atttcttctt gcattatctg
      541 gtaatagtag ggaactagta ttggattgaa tgaatagtct tccattttgg aaacgttcat
      601 ccactctcat atttattttt tggtgcctgc atgtttgaag actgaagcag gctaaaagct
      661 cttgatgaaa tttgagggtg ctgaagatgt tcccactaat ttccagccat cacctttggt
      721 ggggtgggct tcggaggaca gtctgtctga acctgccagt gctgaccctg cagcactttc
      781 agcatatgca catcaaagtt ggagaccgcg ctgaacttag gagggccttc acacagactg
      841 atgtggctac cttctcagaa ttaacagggg atgtcaatcc tttgcatttg aatgaagact
      901 ttgcaaaaca caccaagttt ggaaatacaa ttgtacatgg agttttgatc aacggactta
      961 tctcagctct cctaggaact aaaatgccag ggccaggctg tgtatttctt tcccaggaaa
     1021 ttagctttcc agccccttta tatattggag aagttgtttt agcttctgca gaagtgaaaa
     1081 agctgaagcg gttcattgct attattgcag tgtcatgttc tgtaatagaa agtaaaaaga
     1141 ctgttatgga aggctgggtt aaagttatgg ttccagaagc ttccaaatcc tgaaatagat
     1201 gttttaaaga tgcaacctca aacaccaatg ctgttgttaa agagcctatg gggaattgct
     1261 gctctttacc aaagaatggt tgataggccc agaagcccat cttagttagg ggaagggagc
     1321 aggaagaggg ttgttcaaat gcccactttc cagtttggcc ttatgcttca tgcagacttg
     1381 agtgtatgca ggatttcatt atctgcctgg gttttttgtt tgttttttgt tttttaattc
     1441 aagaagtagg ctgggcccgg tggctcatgc ctgtaatcct ggcactttgg gaggctgcgg
     1501 caggcggatc acttgaggtc aggagtccaa gaccagcctg gccaacatgg tgaaacccca
     1561 tctctaccaa aaaaaaaaaa aaaaaaaaag tgcaactagc tgtgcttggt gacttggccc
     1621 tgtagtccca gttgcttggg aggctgaggt gggagaattg cttgggcctg agagctggag
     1681 gttatggtga gaaactgaga ttgcaccact gcactgtagc ctgagtgaca gagcgagacc
     1741 ctgtctcaag aaagaagtat tgggaaggtt atttaaagac tctactttta aatcaggcgt
     1801 ggcagctcac gcctgtaatc ccagcatttt gggaggctga ggcaggcgaa tcacttgagg
     1861 tcaggagttc aagaccagcc tggccaacat gtgaaacccc atctctacta aaaatacaaa
     1921 aactaaccgg gcatggtggc gggcacctgt aatcccagct acttgggagg ctgaggcagg
     1981 agaatctctt gaacctggga ggttgcagtg agctgaaatc acaccactgc acttcagcct
     2041 gggtgacaga gcaaaactcc acctcaaaaa aaaaaaaaag attctacttt tagaaattca
     2101 gacctagata gatttgcatt tggataacaa atccctacct atagccatgt ggaagcagct
     2161 tgtcactgta ttttaactgt gtaacaatta ttgaaggcga aaatagaagt tgggtcatct
     2221 ttgaacacct accttttatc aatgaatatt tttagactgt tcttcagtat ctgagtcaga
     2281 gtttattgta atttgttatt tacaccaagg tggcatctta gtctaccttc agtgagactt
     2341 gcgtttcagg ggaggggcgt atgtgcatcc tcggtctcag ttatgtaaac ggtctgatct
     2401 gtaaaatagt ggtagcacat gccatgtggg atagttggtg gagatgatag atggagttaa
     2461 gcacagggcc cagcctgtca gcagtagcta ctattattgt tgcccatttc ccctgcaact
     2521 gaggtgagag gttttcctga gtttgaagct gactggccca cagttaaacg taacagacca
     2581 gtttttcagg gtgtcagcca acctctatta gtgttcttaa gtacagtttc tgttataaaa
     2641 gttcagatta ttccttgaaa atttggatct acctcccatt attatgagta atacatgctt
     2701 atagtaaaaa aaaaaaaatt gtaagaaata aatattaaga agattatgga ggccaaattc
     2761 ttaagacttt gggggctggg gtcagggagg ttatattgaa ggggagatgt gcctaacatg
     2821 ttactactaa atggccatcc caacacagcc aacacttttg tttcccattt ttttttgttt
     2881 cccgtttttt aataaaattg agatataatt cacataccat aaaattcacc ttttaaaagt
     2941 gtacagttta gtggttttca gaatatccac aaagttgtac aaccatcacc aaatcaattt
     3001 tttatagcat ttttcatcac ccccaaaaga acctcccatt agcagtcaat ccatttctct
     3061 cctccagtct ttgggaatca ccagtctact ttctgtctct atgggtttcc ctgttctgga
     3121 catttcataa aagttcatac aatgtatgat cctttggaac tggcttcttt gatatagcat
     3181 gttttcaggg ttcatccatg ttacagcatg tatcagtaca tcattttatt ttatggctga
     3241 ataatattcc attgtattta cccata
//
