LOCUS       NM_001003               1174 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1),
            transcript variant 1, mRNA.
ACCESSION   NM_001003 NM_001080857
VERSION     NM_001003.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1174)
  AUTHORS   Tripathi,M., Gauthier,K., Sandireddy,R., Zhou,J., Guptta,P.,
            Sakthivel,S., Teo,W.W., Naing,Y.T., Arul,K., Tikno,K., Park,S.H.,
            Wu,Y., Wang,L., Bay,B.H., Sun,L., Giguere,V., Chow,P.K.H.,
            Ghosh,S., McDonnell,D.P., Yen,P.M. and Singh,B.K.
  TITLE     Esrra regulates Rplp1-mediated translation of lysosome proteins
            suppressed in metabolic dysfunction-associated steatohepatitis and
            reversed by alternate day fasting
  JOURNAL   Mol Metab 87, 101997 (2024)
   PUBMED   39032642
  REMARK    GeneRIF: Esrra regulates Rplp1-mediated translation of lysosome
            proteins suppressed in metabolic dysfunction-associated
            steatohepatitis and reversed by alternate day fasting.
REFERENCE   2  (bases 1 to 1174)
  AUTHORS   Yang,W., Wang,H., Li,Z., Zhang,L., Liu,J., Kirchhoff,F., Huan,C.
            and Zhang,W.
  TITLE     RPLP1 restricts HIV-1 transcription by disrupting C/EBPbeta binding
            to the LTR
  JOURNAL   Nat Commun 15 (1), 5290 (2024)
   PUBMED   38906865
  REMARK    GeneRIF: RPLP1 restricts HIV-1 transcription by disrupting
            C/EBPbeta binding to the LTR.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1174)
  AUTHORS   Peterson,R., Minchella,P., Cui,W., Graham,A. and Nothnick,W.B.
  TITLE     RPLP1 Is Up-Regulated in Human Adenomyosis and Endometrial
            Adenocarcinoma Epithelial Cells and Is Essential for Cell Survival
            and Migration In Vitro
  JOURNAL   Int J Mol Sci 24 (3), 2690 (2023)
   PUBMED   36769010
  REMARK    GeneRIF: RPLP1 Is Up-Regulated in Human Adenomyosis and Endometrial
            Adenocarcinoma Epithelial Cells and Is Essential for Cell Survival
            and Migration In Vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1174)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1174)
  AUTHORS   Horbowicz-Drozdzal,P., Kamel,K., Kmiecik,S., Borkiewicz,L.,
            Tumer,N.E., Shaw,P.C., Tchorzewski,M. and Grela,P.
  TITLE     Phosphorylation of the conserved C-terminal domain of ribosomal
            P-proteins impairs the mode of interaction with plant toxins
  JOURNAL   FEBS Lett 595 (17), 2221-2236 (2021)
   PUBMED   34328639
  REMARK    GeneRIF: Phosphorylation of the conserved C-terminal domain of
            ribosomal P-proteins impairs the mode of interaction with plant
            toxins.
REFERENCE   6  (bases 1 to 1174)
  AUTHORS   Chan,S.H., Hung,F.S., Chan,D.S. and Shaw,P.C.
  TITLE     Trichosanthin interacts with acidic ribosomal proteins P0 and P1
            and mitotic checkpoint protein MAD2B
  JOURNAL   Eur J Biochem 268 (7), 2107-2112 (2001)
   PUBMED   11277934
REFERENCE   7  (bases 1 to 1174)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   8  (bases 1 to 1174)
  AUTHORS   Tchorzewski,M., Boldyreff,B., Issinger,O.G. and Grankowski,N.
  TITLE     Analysis of the protein-protein interactions between the human
            acidic ribosomal P-proteins: evaluation by the two hybrid system
  JOURNAL   Int J Biochem Cell Biol 32 (7), 737-746 (2000)
   PUBMED   10856704
REFERENCE   9  (bases 1 to 1174)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 1174)
  AUTHORS   Rich,B.E. and Steitz,J.A.
  TITLE     Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of
            cDNA clones, in vitro synthesis, and assembly
  JOURNAL   Mol Cell Biol 7 (11), 4065-4074 (1987)
   PUBMED   3323886
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC027237.8.
            
            On Nov 25, 2018 this sequence version replaced NM_001003.2.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            phosphoprotein that is a component of the 60S subunit. The protein,
            which is a functional equivalent of the E. coli L7/L12 ribosomal
            protein, belongs to the L12P family of ribosomal proteins. It plays
            an important role in the elongation step of protein synthesis.
            Unlike most ribosomal proteins, which are basic, the encoded
            protein is acidic. Its C-terminal end is nearly identical to the
            C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1
            protein can interact with P0 and P2 to form a pentameric complex
            consisting of P1 and P2 dimers, and a P0 monomer. The protein is
            located in the cytoplasm. Two alternatively spliced transcript
            variants that encode different proteins have been observed. As is
            typical for genes encoding ribosomal proteins, there are multiple
            processed pseudogenes of this gene dispersed through the genome.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This predominant variant (1) is the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP367167.1, SRR5189652.227177.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260379.11/ ENSP00000346037.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC027237.8         46841-47043         c
            204-278             AC027237.8         46140-46214         c
            279-396             AC027237.8         44574-44691         c
            397-1174            AC027237.8         43656-44433         c
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..1174
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /note="ribosomal protein lateral stalk subunit P1"
                     /db_xref="GeneID:6176"
                     /db_xref="HGNC:HGNC:10372"
                     /db_xref="MIM:180520"
     exon            1..203
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..476
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /note="isoform 1 is encoded by transcript variant 1; 60S
                     acidic ribosomal protein P1; acidic ribosomal
                     phosphoprotein P1; ribosomal protein, large, P1; large
                     ribosomal subunit protein P1"
                     /codon_start=1
                     /product="large ribosomal subunit protein P1 isoform 1"
                     /protein_id="NP_000994.1"
                     /db_xref="CCDS:CCDS10233.1"
                     /db_xref="GeneID:6176"
                     /db_xref="HGNC:HGNC:10372"
                     /db_xref="MIM:180520"
                     /translation="MASVSELACIYSALILHDDEVTVTEDKINALIKAAGVNVEPFWP
                     GLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESE
                     ESDDDMGFGLFD"
     exon            204..278
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..396
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..1174
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      497..502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /note="hexamer: AATAAA"
     polyA_site      515
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /note="major polyA site"
     polyA_site      545
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
     regulatory      1139..1144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
                     /note="hexamer: AATAAA"
     polyA_site      1174
                     /gene="RPLP1"
                     /gene_synonym="LP1; P1; RPP1"
ORIGIN      
        1 cccctttcct cagctgccgc caaggtgctc ggtccttccg aggaagctaa ggctgcgttg
       61 gggtgaggcc ctcacttcat ccggcgacta gcaccgcgtc cggcagcgcc agccctacac
      121 tcgcccgcgc catggcctct gtctccgagc tcgcctgcat ctactcggcc ctcattctgc
      181 acgacgatga ggtgacagtc acggaggata agatcaatgc cctcattaaa gcagccggtg
      241 taaatgttga gcctttttgg cctggcttgt ttgcaaaggc cctggccaac gtcaacattg
      301 ggagcctcat ctgcaatgta ggggccggtg gacctgctcc agcagctggt gctgcaccag
      361 caggaggtcc tgccccctcc actgctgctg ctccagctga ggagaagaaa gtggaagcaa
      421 agaaagaaga atccgaggag tctgatgatg acatgggctt tggtcttttt gactaaacct
      481 cttttataac atgttcaata aaaagctgaa ctttactgct gttggtcttg tccatagttt
      541 tggaatgtgc tctgcaaaaa tggtctgttt tgtaatgttg gctttcagcc tattctgcca
      601 tgacacaggc tggattttcc ctgccaccat tgccggatgt gagatttaga caatcctgat
      661 gctaacaaga aggcacctca tggtacagtg ttgaaaactg cactggggtg gcaggaggaa
      721 ggatcagagc agatgctttg tccaggttac ctgtgtaaac ttgatgatta taaggtgtgt
      781 cccctacact gggggtggag ggtaatacag accagcttta gaaagcctcc tgggtattta
      841 ccctatacaa ccctgcctaa gaacgaactt tgacgtatgc tgaatgttga ctgctacatc
      901 ccaaggttgt aaaaaaacaa gacttagcta tgtaatgtct caccaaatgt ttgggagttt
      961 tatggtaaca ctgaaggagt gcagaaagtt tacttaatag tttattaagg tctccagtta
     1021 cacaaagtgg aaaaaaaaaa agattcaaac ctgtgttcca aaaactaaga gctttttttg
     1081 tttgccaatt aataatacca tgaatggaat tttcaacttt tcaggcttgg atttatataa
     1141 taaaccgtgg gtattgtgtg ttcagagcag ctaa
//
