LOCUS       NM_001002               1105 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0),
            transcript variant 1, mRNA.
ACCESSION   NM_001002
VERSION     NM_001002.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1105)
  AUTHORS   Ge,Y.L., Li,P.J., Bu,Y.R., Zhang,B., Xu,J., He,S.Y., Cao,Q.L.,
            Bai,Y.G., Ma,J., Zhang,L., Zhou,J. and Xie,M.J.
  TITLE     TNF-alpha and RPLP0 drive the apoptosis of endothelial cells and
            increase susceptibility to high-altitude pulmonary edema
  JOURNAL   Apoptosis 29 (9-10), 1600-1618 (2024)
   PUBMED   39110356
  REMARK    GeneRIF: TNF-alpha and RPLP0 drive the apoptosis of endothelial
            cells and increase susceptibility to high-altitude pulmonary edema.
REFERENCE   2  (bases 1 to 1105)
  AUTHORS   Wang,Y.L., Zhao,W.W., Bai,S.M., Ma,Y., Yin,X.K., Feng,L.L.,
            Zeng,G.D., Wang,F., Feng,W.X., Zheng,J., Wang,Y.N., Zeng,B.,
            Liu,Q., Hung,M.C. and Wan,X.B.
  TITLE     DNA damage-induced paraspeckle formation enhances DNA repair and
            tumor radioresistance by recruiting ribosomal protein P0
  JOURNAL   Cell Death Dis 13 (8), 709 (2022)
   PUBMED   35974014
  REMARK    GeneRIF: DNA damage-induced paraspeckle formation enhances DNA
            repair and tumor radioresistance by recruiting ribosomal protein
            P0.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1105)
  AUTHORS   Borrello,M.T., Santofimia-Castano,P., Bocchio,M., Listi,A.,
            Fraunhoffer,N., Soubeyran,P., Chevet,E., Pin,C. and Iovanna,J.
  TITLE     NUPR1 interacts with eIF2alpha and is required for resolution of
            the ER stress response in pancreatic tissue
  JOURNAL   FEBS J 288 (13), 4081-4097 (2021)
   PUBMED   33403797
REFERENCE   4  (bases 1 to 1105)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1105)
  AUTHORS   Filipek,K., Michalec-Wawiorka,B., Boguszewska,A., Kmiecik,S. and
            Tchorzewski,M.
  TITLE     Phosphorylation of the N-terminal domain of ribosomal P-stalk
            protein uL10 governs its association with the ribosome
  JOURNAL   FEBS Lett 594 (18), 3002-3019 (2020)
   PUBMED   32668052
  REMARK    GeneRIF: Phosphorylation of the N-terminal domain of ribosomal
            P-stalk protein uL10 governs its association with the ribosome.
REFERENCE   6  (bases 1 to 1105)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
REFERENCE   7  (bases 1 to 1105)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 1105)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   9  (bases 1 to 1105)
  AUTHORS   Rich,B.E. and Steitz,J.A.
  TITLE     Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of
            cDNA clones, in vitro synthesis, and assembly
  JOURNAL   Mol Cell Biol 7 (11), 4065-4074 (1987)
   PUBMED   3323886
REFERENCE   10 (bases 1 to 1105)
  AUTHORS   Towbin,H., Ramjoue,H.P., Kuster,H., Liverani,D. and Gordon,J.
  TITLE     Monoclonal antibodies against eucaryotic ribosomes. Use to
            characterize a ribosomal protein not previously identified and
            antigenically related to the acidic phosphoproteins P1/P2
  JOURNAL   J Biol Chem 257 (21), 12709-12715 (1982)
   PUBMED   6182142
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BF131912.1, BC000087.2, BC019014.2 and AC004263.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001002.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein, which
            is the functional equivalent of the E. coli L10 ribosomal protein,
            belongs to the L10P family of ribosomal proteins. It is a neutral
            phosphoprotein with a C-terminal end that is nearly identical to
            the C-terminal ends of the acidic ribosomal phosphoproteins P1 and
            P2. The P0 protein can interact with P1 and P2 to form a pentameric
            complex consisting of P1 and P2 dimers, and a P0 monomer. The
            protein is located in the cytoplasm. Transcript variants derived
            from alternative splicing exist; they encode the same protein. As
            is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the predominant transcript.
            It has a different 5' UTR than variant 2. They encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.187834.1,
                                           SRR5189664.41454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392514.9/ ENSP00000376299.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BF131912.1         101-116
            17-1102             BC000087.2         1-1086
            1103-1104           BC019014.2         1144-1145
            1105-1105           AC004263.1         4418-4418           c
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..1105
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /note="ribosomal protein lateral stalk subunit P0"
                     /db_xref="GeneID:6175"
                     /db_xref="HGNC:HGNC:10371"
                     /db_xref="MIM:180510"
     exon            1..29
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /inference="alignment:Splign:2.1.0"
     exon            30..131
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1031
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /note="acidic ribosomal phosphoprotein P0; 60S acidic
                     ribosomal protein P0; 60S ribosomal protein L10E;
                     ribosomal protein, large, P0; neutral ribosomal
                     phosphoprotein P0"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL10"
                     /protein_id="NP_000993.1"
                     /db_xref="CCDS:CCDS9193.1"
                     /db_xref="GeneID:6175"
                     /db_xref="HGNC:HGNC:10371"
                     /db_xref="MIM:180510"
                     /translation="MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIR
                     MSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDML
                     LANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQL
                     IKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEG
                     VRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFV
                     AAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD"
     exon            132..307
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /inference="alignment:Splign:2.1.0"
     exon            308..395
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /inference="alignment:Splign:2.1.0"
     exon            396..542
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /inference="alignment:Splign:2.1.0"
     exon            543..728
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /inference="alignment:Splign:2.1.0"
     exon            729..869
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1105
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1079..1084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /note="hexamer: AATAAA"
     polyA_site      1105
                     /gene="RPLP0"
                     /gene_synonym="L10E; LP0; P0; PRLP0; RPP0; uL10"
                     /note="major polyA site"
ORIGIN      
        1 ccttctctcg ccaggcgtcc tcgtggaagt gacatcgtct ttaaaccctg cgtggcaatc
       61 cctgacgcac cgccgtgatg cccagggaag acagggcgac ctggaagtcc aactacttcc
      121 ttaagatcat ccaactattg gatgattatc cgaaatgttt cattgtggga gcagacaatg
      181 tgggctccaa gcagatgcag cagatccgca tgtcccttcg cgggaaggct gtggtgctga
      241 tgggcaagaa caccatgatg cgcaaggcca tccgagggca cctggaaaac aacccagctc
      301 tggagaaact gctgcctcat atccggggga atgtgggctt tgtgttcacc aaggaggacc
      361 tcactgagat cagggacatg ttgctggcca ataaggtgcc agctgctgcc cgtgctggtg
      421 ccattgcccc atgtgaagtc actgtgccag cccagaacac tggtctcggg cccgagaaga
      481 cctccttttt ccaggcttta ggtatcacca ctaaaatctc caggggcacc attgaaatcc
      541 tgagtgatgt gcagctgatc aagactggag acaaagtggg agccagcgaa gccacgctgc
      601 tgaacatgct caacatctcc cccttctcct ttgggctggt catccagcag gtgttcgaca
      661 atggcagcat ctacaaccct gaagtgcttg atatcacaga ggaaactctg cattctcgct
      721 tcctggaggg tgtccgcaat gttgccagtg tctgtctgca gattggctac ccaactgttg
      781 catcagtacc ccattctatc atcaacgggt acaaacgagt cctggccttg tctgtggaga
      841 cggattacac cttcccactt gctgaaaagg tcaaggcctt cttggctgat ccatctgcct
      901 ttgtggctgc tgcccctgtg gctgctgcca ccacagctgc tcctgctgct gctgcagccc
      961 cagctaaggt tgaagccaag gaagagtcgg aggagtcgga cgaggatatg ggatttggtc
     1021 tctttgacta atcaccaaaa agcaaccaac ttagccagtt ttatttgcaa aacaaggaaa
     1081 taaaggctta cttctttaaa aagtc
//
