LOCUS       NM_000661                724 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L9 (RPL9), transcript variant 1,
            mRNA.
ACCESSION   NM_000661
VERSION     NM_000661.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   Li,A., Xie,J., Lv,L., Zheng,Z., Yang,W., Zhuo,W., Yang,S., Cai,D.,
            Duan,J., Liu,P., Min,J. and Wei,J.
  TITLE     RPL9 acts as an oncogene by shuttling miRNAs through exosomes in
            human hepatocellular carcinoma cells
  JOURNAL   Int J Oncol 64 (6) (2024)
   PUBMED   38639179
  REMARK    GeneRIF: RPL9 acts as an oncogene by shuttling miRNAs through
            exosomes in human hepatocellular carcinoma cells.
REFERENCE   2  (bases 1 to 724)
  AUTHORS   Zhang,H., Zhang,H. and Chen,C.
  TITLE     Investigating the folding mechanism of the N-terminal domain of
            ribosomal protein L9
  JOURNAL   Proteins 89 (7), 832-844 (2021)
   PUBMED   33576138
  REMARK    GeneRIF: Investigating the folding mechanism of the N-terminal
            domain of ribosomal protein L9.
REFERENCE   3  (bases 1 to 724)
  AUTHORS   Hassan,F.M., Alsultan,A., Alzehrani,F., Albuali,W., Bubshait,D.,
            Abass,E., Elbasheer,M. and Alkhanbashi,A.
  TITLE     Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients
            Diagnosed with Thrombosis
  JOURNAL   Med Arch 75 (3), 188-193 (2021)
   PUBMED   34483448
  REMARK    GeneRIF: Genetic Variants of RPL5 and RPL9 Genes among Saudi
            Patients Diagnosed with Thrombosis.
REFERENCE   4  (bases 1 to 724)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 724)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 724)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   7  (bases 1 to 724)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 724)
  AUTHORS   Mazuruk,K., Schoen,T.J., Chader,G.J., Iwata,T. and Rodriguez,I.R.
  TITLE     Structural organization and chromosomal localization of the human
            ribosomal protein L9 gene
  JOURNAL   Biochim Biophys Acta 1305 (3), 151-162 (1996)
   PUBMED   8597601
REFERENCE   9  (bases 1 to 724)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 724)
  AUTHORS   Hori,N., Murakawa,K., Matoba,R., Fukushima,A., Okubo,K. and
            Matsubara,K.
  TITLE     A new human ribosomal protein sequence, homologue of rat L9
  JOURNAL   Nucleic Acids Res 21 (18), 4395 (1993)
   PUBMED   8415001
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BM841336.1, BC066318.1 and BC031906.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 19, 2020 this sequence version replaced NM_000661.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L6P family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and the predominant variant. Variants 1 and 2 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU599275.1, CD387625.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295955.14/ ENSP00000346022.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BM841336.1         27-33
            8-711               BC066318.1         1-704
            712-724             BC031906.1         685-697
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..724
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /note="ribosomal protein L9"
                     /db_xref="GeneID:6133"
                     /db_xref="HGNC:HGNC:10369"
                     /db_xref="MIM:603686"
     exon            1..32
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /inference="alignment:Splign:2.1.0"
     exon            33..79
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..612
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /note="60S ribosomal protein L9"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL6"
                     /protein_id="NP_000652.2"
                     /db_xref="CCDS:CCDS3452.1"
                     /db_xref="GeneID:6133"
                     /db_xref="HGNC:HGNC:10369"
                     /db_xref="MIM:603686"
                     /translation="MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVE
                     LSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPIN
                     VVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAAL
                     IQQATTVKNKDIRKFLDGIYVSEKGTVQQADE"
     exon            80..195
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /inference="alignment:Splign:2.1.0"
     exon            196..291
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /inference="alignment:Splign:2.1.0"
     exon            292..424
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /inference="alignment:Splign:2.1.0"
     exon            425..505
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /inference="alignment:Splign:2.1.0"
     exon            506..622
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /inference="alignment:Splign:2.1.0"
     exon            623..724
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      689..694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /note="hexamer: AATAAA"
     polyA_site      724
                     /gene="RPL9"
                     /gene_synonym="L9; NPC-A-16; uL6"
                     /note="major polyA site"
ORIGIN      
        1 agacgttctt tctttgctgc gtctactgcg agaatgaaga ctattctcag caatcagact
       61 gtcgacattc cagaaaatgt cgacattact ctgaagggac gcacagttat cgtgaagggc
      121 cccagaggaa ccctgcggag ggacttcaat cacatcaatg tagaactcag ccttcttgga
      181 aagaaaaaaa agaggctccg ggttgacaaa tggtggggta acagaaagga actggctacc
      241 gttcggacta tttgtagtca tgtacagaac atgatcaagg gtgttacact gggcttccgt
      301 tacaagatga ggtctgtgta tgctcacttc cccatcaacg ttgttatcca ggagaatggg
      361 tctcttgttg aaatccgaaa tttcttgggt gaaaaatata tccgcagggt tcggatgaga
      421 ccaggtgttg cttgttcagt atctcaagcc cagaaagatg aattaatcct tgaaggaaat
      481 gacattgagc ttgtttcaaa ttcagcggct ttgattcagc aagccacaac agttaaaaac
      541 aaggatatca ggaaattttt ggatggtatc tatgtctctg aaaaaggaac tgttcagcag
      601 gctgatgaat aagatctaag agttacctgg ctacagaaag aagatgccag atgacactta
      661 agacctactt gtgatattta aatgatgcaa taaaagacct attgatttgg accttcttct
      721 taaa
//
