LOCUS       NM_000972                887 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ribosomal protein L7a (RPL7A), mRNA.
ACCESSION   NM_000972
VERSION     NM_000972.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   2  (bases 1 to 887)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 887)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 887)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 887)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 887)
  AUTHORS   Burris,T.P., Nawaz,Z., Tsai,M.J. and O'Malley,B.W.
  TITLE     A nuclear hormone receptor-associated protein that inhibits
            transactivation by the thyroid hormone and retinoic acid receptors
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9525-9529 (1995)
   PUBMED   7568167
REFERENCE   7  (bases 1 to 887)
  AUTHORS   Colombo,P., Yon,J. and Fried,M.
  TITLE     The organization and expression of the human L7a ribosomal protein
            gene
  JOURNAL   Biochim Biophys Acta 1129 (1), 93-95 (1991)
   PUBMED   1756182
REFERENCE   8  (bases 1 to 887)
  AUTHORS   Ben-Ishai,R., Scharf,R., Sharon,R. and Kapten,I.
  TITLE     A human cellular sequence implicated in trk oncogene activation is
            DNA damage inducible
  JOURNAL   Proc Natl Acad Sci U S A 87 (16), 6039-6043 (1990)
   PUBMED   1696715
REFERENCE   9  (bases 1 to 887)
  AUTHORS   Ziemiecki,A., Muller,R.G., Fu,X.C., Hynes,N.E. and Kozma,S.
  TITLE     Oncogenic activation of the human trk proto-oncogene by
            recombination with the ribosomal large subunit protein L7a
  JOURNAL   EMBO J 9 (1), 191-196 (1990)
   PUBMED   2403926
REFERENCE   10 (bases 1 to 887)
  AUTHORS   Kozma,S.C., Redmond,S.M., Fu,X.C., Saurer,S.M., Groner,B. and
            Hynes,N.E.
  TITLE     Activation of the receptor kinase domain of the trk oncogene by
            recombination with two different cellular sequences
  JOURNAL   EMBO J 7 (1), 147-154 (1988)
   PUBMED   2966065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AL772161.10 and AL593848.15.
            
            On Nov 26, 2018 this sequence version replaced NM_000972.2.
            
            Summary: Cytoplasmic ribosomes, organelles that catalyze protein
            synthesis, consist of a small 40S subunit and a large 60S subunit.
            Together these subunits are composed of 4 RNA species and
            approximately 80 structurally distinct proteins. This gene encodes
            a ribosomal protein that is a component of the 60S subunit. The
            protein belongs to the L7AE family of ribosomal proteins. It can
            interact with a subclass of nuclear hormone receptors, including
            thyroid hormone receptor, and inhibit their ability to
            transactivate by preventing their binding to their DNA response
            elements. This gene is included in the surfeit gene cluster, a
            group of very tightly linked genes that do not share sequence
            similarity. It is co-transcribed with the U24, U36a, U36b, and U36c
            small nucleolar RNA genes, which are located in its second, fifth,
            fourth, and sixth introns, respectively. This gene rearranges with
            the trk proto-oncogene to form the chimeric oncogene trk-2h, which
            encodes an oncoprotein consisting of the N terminus of ribosomal
            protein L7a fused to the receptor tyrosine kinase domain of trk. As
            is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.152640.1,
                                           SRR5189655.22992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323345.11/ ENSP00000361076.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL772161.10        147215-147243
            30-150              AL772161.10        147919-148039
            151-300             AL772161.10        148548-148697
            301-441             AL772161.10        148909-149049
            442-521             AL772161.10        149237-149316
            522-652             AL593848.15        2112-2242
            653-722             AL593848.15        2517-2586
            723-887             AL593848.15        2777-2941
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..887
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /note="ribosomal protein L7a"
                     /db_xref="GeneID:6130"
                     /db_xref="HGNC:HGNC:10364"
                     /db_xref="MIM:185640"
     exon            1..29
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..827
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /note="surfeit 3; surfeit locus protein 3; PLA-X
                     polypeptide; 60S ribosomal protein L7a; thyroid hormone
                     receptor uncoupling protein"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL8"
                     /protein_id="NP_000963.1"
                     /db_xref="CCDS:CCDS6965.1"
                     /db_xref="GeneID:6130"
                     /db_xref="HGNC:HGNC:10364"
                     /db_xref="MIM:185640"
                     /translation="MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQD
                     IQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKY
                     RPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHD
                     VDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKL
                     VEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG"
     exon            30..150
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /inference="alignment:Splign:2.1.0"
     exon            151..300
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /inference="alignment:Splign:2.1.0"
     exon            301..441
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /inference="alignment:Splign:2.1.0"
     exon            442..521
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /inference="alignment:Splign:2.1.0"
     exon            522..652
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /inference="alignment:Splign:2.1.0"
     exon            653..722
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /inference="alignment:Splign:2.1.0"
     exon            723..887
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      870..875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /note="hexamer: AATACA"
     polyA_site      887
                     /gene="RPL7A"
                     /gene_synonym="eL8; L7A; SURF3; TRUP"
                     /note="major polyA site"
ORIGIN      
        1 ctttctctct cctcccgccg cccaagatgc cgaaaggaaa gaaggccaag ggaaagaagg
       61 tggctccggc cccagctgtc gtgaagaagc aggaggctaa gaaagtggtg aatcccctgt
      121 ttgagaaaag gcctaagaat tttggcattg gacaggacat ccagcccaaa agagacctca
      181 cccgctttgt gaaatggccc cgctatatca ggttgcagcg gcagagagcc atcctctata
      241 agcggctgaa agtgcctcct gcgattaacc agttcaccca ggccctggac cgccaaacag
      301 ctactcagct gcttaagctg gcccacaagt acagaccaga gacaaagcaa gagaagaagc
      361 agagactgtt ggcccgggcc gagaagaagg ctgctggcaa aggggacgtc ccaacgaaga
      421 gaccacctgt ccttcgagca ggagttaaca ccgtcaccac cttggtggag aacaagaaag
      481 ctcagctggt ggtgattgca cacgacgtgg atcccatcga gctggttgtc ttcttgcctg
      541 ccctgtgtcg taaaatgggg gtcccttact gcattatcaa gggaaaggca agactgggac
      601 gtctagtcca caggaagacc tgcaccactg tcgccttcac acaggtgaac tcggaagaca
      661 aaggcgcttt ggctaagctg gtggaagcta tcaggaccaa ttacaatgac agatacgatg
      721 agatccgccg tcactggggt ggcaatgtcc tgggtcctaa gtctgtggct cgtatcgcca
      781 agctcgaaaa ggcaaaggct aaagaacttg ccactaaact gggttaaatg tacactgttg
      841 agttttctgt acataaaaat aattgaaata atacaaattt tccttca
//
