LOCUS       NM_000971               1233 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ribosomal protein L7 (RPL7), transcript variant 1,
            mRNA.
ACCESSION   NM_000971
VERSION     NM_000971.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1233)
  AUTHORS   Karnib,H., Nadeem,M.F., Humbert,N., Sharma,K.K., Grytsyk,N.,
            Tisne,C., Boutant,E., Lequeu,T., Real,E., Boudier,C., de
            Rocquigny,H. and Mely,Y.
  TITLE     The nucleic acid chaperone activity of the HIV-1 Gag polyprotein is
            boosted by its cellular partner RPL7: a kinetic study
  JOURNAL   Nucleic Acids Res 48 (16), 9218-9234 (2020)
   PUBMED   32797159
  REMARK    GeneRIF: The nucleic acid chaperone activity of the HIV-1 Gag
            polyprotein is boosted by its cellular partner RPL7: a kinetic
            study.
REFERENCE   2  (bases 1 to 1233)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1233)
  AUTHORS   Mekdad,H.E., Boutant,E., Karnib,H., Biedma,M.E., Sharma,K.K.,
            Malytska,I., Laumond,G., Roy,M., Real,E., Paillart,J.C., Moog,C.,
            Darlix,J.L., Mely,Y. and de Rocquigny,H.
  TITLE     Characterization of the interaction between the HIV-1 Gag
            structural polyprotein and the cellular ribosomal protein L7 and
            its implication in viral nucleic acid remodeling
  JOURNAL   Retrovirology 13 (1), 54 (2016)
   PUBMED   27515235
  REMARK    GeneRIF: HIV-1 Gag NC domain interacts with the ribosomal protein
            RPL7 endowed with nucleic acid chaperone activity, favoring the
            notion that RPL7 could be a Gag helper chaperoning factor possibly
            contributing to the start of Gag assembly
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1233)
  AUTHORS   Li,Y., Jain,N., Limpanawat,S., To,J., Quistgaard,E.M., Nordlund,P.,
            Thanabalu,T. and Torres,J.
  TITLE     Interaction between human BAP31 and respiratory syncytial virus
            small hydrophobic (SH) protein
  JOURNAL   Virology 482, 105-110 (2015)
   PUBMED   25854864
REFERENCE   5  (bases 1 to 1233)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 1233)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   7  (bases 1 to 1233)
  AUTHORS   Neumann,F., Hemmerich,P., von Mikecz,A., Peter,H.H. and
            Krawinkel,U.
  TITLE     Human ribosomal protein L7 inhibits cell-free translation in
            reticulocyte lysates and affects the expression of nuclear proteins
            upon stable transfection into Jurkat T-lymphoma cells
  JOURNAL   Nucleic Acids Res 23 (2), 195-202 (1995)
   PUBMED   7862521
REFERENCE   8  (bases 1 to 1233)
  AUTHORS   von Mikecz,A., Hemmerich,P., Peter,H.H. and Krawinkel,U.
  TITLE     Characterization of eukaryotic protein L7 as a novel autoantigen
            which frequently elicits an immune response in patients suffering
            from systemic autoimmune disease
  JOURNAL   Immunobiology 192 (1-2), 137-154 (1994)
   PUBMED   7750987
REFERENCE   9  (bases 1 to 1233)
  AUTHORS   Seshadri,T., Uzman,J.A., Oshima,J. and Campisi,J.
  TITLE     Identification of a transcript that is down-regulated in senescent
            human fibroblasts. Cloning, sequence analysis, and regulation of
            the human L7 ribosomal protein gene
  JOURNAL   J Biol Chem 268 (25), 18474-18480 (1993)
   PUBMED   8360149
REFERENCE   10 (bases 1 to 1233)
  AUTHORS   Hemmerich,P., von Mikecz,A., Neumann,F., Sozeri,O.,
            Wolff-Vorbeck,G., Zoebelein,R. and Krawinkel,U.
  TITLE     Structural and functional properties of ribosomal protein L7 from
            humans and rodents
  JOURNAL   Nucleic Acids Res 21 (2), 223-231 (1993)
   PUBMED   8441630
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from X52967.1, BC009599.1 and AC111149.4.
            
            On Nov 23, 2018 this sequence version replaced NM_000971.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L30P family of ribosomal proteins. It contains an N-terminal
            basic region-leucine zipper (BZIP)-like domain and the RNP
            consensus submotif RNP2. In vitro the BZIP-like domain mediates
            homodimerization and stable binding to DNA and RNA, with a
            preference for 28S rRNA and mRNA. The protein can inhibit cell-free
            translation of mRNAs, suggesting that it plays a regulatory role in
            the translation apparatus. It is located in the cytoplasm. The
            protein has been shown to be an autoantigen in patients with
            systemic autoimmune diseases, such as systemic lupus erythematosus.
            As is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.111484.1,
                                           SRR1660803.39838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155371, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352983.7/ ENSP00000339795.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-825               X52967.1           1-825
            826-836             BC009599.1         827-837
            837-1233            AC111149.4         103040-103436
FEATURES             Location/Qualifiers
     source          1..1233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..1233
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /note="ribosomal protein L7"
                     /db_xref="GeneID:6129"
                     /db_xref="HGNC:HGNC:10363"
                     /db_xref="MIM:604166"
     exon            1..35
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..768
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /note="isoform 1 is encoded by transcript variant 1; 60S
                     ribosomal protein L7; large ribosomal subunit protein
                     uL30"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL30 isoform 1"
                     /protein_id="NP_000962.2"
                     /db_xref="CCDS:CCDS6212.1"
                     /db_xref="GeneID:6129"
                     /db_xref="HGNC:HGNC:10363"
                     /db_xref="MIM:604166"
                     /translation="MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRK
                     ARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVS
                     PKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYG
                     KINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRG
                     GMKKKTTHFVEGGDAGNREDQINRLIRRMN"
     exon            36..144
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /inference="alignment:Splign:2.1.0"
     exon            145..311
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /inference="alignment:Splign:2.1.0"
     exon            312..449
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /inference="alignment:Splign:2.1.0"
     exon            450..559
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /inference="alignment:Splign:2.1.0"
     exon            560..769
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1233
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      806..811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /note="hexamer: AATAAA"
     regulatory      833..838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /note="hexamer: AATATA"
     polyA_site      838
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /note="major polyA site"
     polyA_site      853
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /note="major polyA site"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
                     /note="hexamer: TATAAA"
     polyA_site      1233
                     /gene="RPL7"
                     /gene_synonym="humL7-1; L7; uL30"
ORIGIN      
        1 cctctttttc cggctggaac catggagggt gtagaagaga agaagaagga ggttcctgct
       61 gtgccagaaa cccttaagaa aaagcgaagg aatttcgcag agctgaagat caagcgcctg
      121 agaaagaagt ttgcccaaaa gatgcttcga aaggcaagga ggaagcttat ctatgaaaaa
      181 gcaaagcact atcacaagga atataggcag atgtacagaa ctgaaattcg aatggcgagg
      241 atggcaagaa aagctggcaa cttctatgta cctgcagaac ccaaattggc gtttgtcatc
      301 agaatcagag gtatcaatgg agtgagccca aaggttcgaa aggtgttgca gcttcttcgc
      361 cttcgtcaaa tcttcaatgg aacctttgtg aagctcaaca aggcttcgat taacatgctg
      421 aggattgtag agccatatat tgcatggggg taccccaatc tgaagtcagt aaatgaacta
      481 atctacaagc gtggttatgg caaaatcaat aagaagcgaa ttgctttgac agataacgct
      541 ttgattgctc gatctcttgg taaatacggc atcatctgca tggaggattt gattcatgag
      601 atctatactg ttggaaaacg cttcaaagag gcaaataact tcctgtggcc cttcaaattg
      661 tcttctccac gaggtggaat gaagaaaaag accacccatt ttgtagaagg tggagatgct
      721 ggcaacaggg aggaccagat caacaggctt attagaagaa tgaactaagg tgtctaccat
      781 gattattttt ctaagctggt tggttaataa acagtacctg ctctcaaatt gaaatatatt
      841 gttgtatttg tgatttgttg ttgttgttgt tagcctgcct ctgtcttccc ttaactactg
      901 tggcaagtgt ggtgtgtgat aaaattaagc caaatcaaca gcccatttcg tgcaaaatca
      961 gggtcgagtc tgtgtgaaag acatctcttg ggtttttaaa aggcttttct atacaaaaga
     1021 ttttaatttt ttgtttttta actgtgctga gtgattcgaa atgggtttat tctaagaaag
     1081 cctgtttcac aagcatttgt acatgatttg tcggtaaggt aatccaactt tggtttatgg
     1141 aaaaaattga atttagttgc taaaatttat ttctcgggcc ttcgcttgtt tataaactgc
     1201 catgtaaatg tgttgttttc cttttgcatt cca
//
