LOCUS       NM_000970                921 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ribosomal protein L6 (RPL6), transcript variant 2,
            mRNA.
ACCESSION   NM_000970
VERSION     NM_000970.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 921)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 921)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 921)
  AUTHORS   Wei,J., Kishton,R.J., Angel,M., Conn,C.S., Dalla-Venezia,N.,
            Marcel,V., Vincent,A., Catez,F., Ferre,S., Ayadi,L., Marchand,V.,
            Dersh,D., Gibbs,J.S., Ivanov,I.P., Fridlyand,N., Coute,Y.,
            Diaz,J.J., Qian,S.B., Staudt,L.M., Restifo,N.P. and Yewdell,J.W.
  TITLE     Ribosomal Proteins Regulate MHC Class I Peptide Generation for
            Immunosurveillance
  JOURNAL   Mol Cell 73 (6), 1162-1173 (2019)
   PUBMED   30712990
  REMARK    GeneRIF: 60S ribosomal proteins L6 (RPL6) and RPL28, which are
            adjacent on the ribosome, play opposite roles in generating an
            influenza A virus-encoded peptide. Depleting RPL6 decreases
            ubiquitin-dependent peptide presentation, whereas depleting RPL28
            increases ubiquitin-dependent and -independent peptide
            presentation.
REFERENCE   4  (bases 1 to 921)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   5  (bases 1 to 921)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 921)
  AUTHORS   Ohta,K., Endo,T., Gunji,K. and Onaya,T.
  TITLE     Isolation of a cDNA whose expression is markedly increased in
            malignantly transformed FRTL cells and neoplastic human thyroid
            tissues
  JOURNAL   J Mol Endocrinol 12 (1), 85-92 (1994)
   PUBMED   8185817
REFERENCE   7  (bases 1 to 921)
  AUTHORS   Zaman,G.J.
  TITLE     Sequence of a cDNA encoding human ribosomal protein L26 and of a
            cDNA probably encoding human ribosomal protein L6
  JOURNAL   Nucleic Acids Res 21 (7), 1673 (1993)
   PUBMED   8479925
REFERENCE   8  (bases 1 to 921)
  AUTHORS   Morita,T., Sato,T., Nyunoya,H., Tsujimoto,A., Takahara,J., Irino,S.
            and Shimotohno,K.
  TITLE     Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107)
            that binds specifically to domain C of the tax-responsive enhancer
            element in the long terminal repeat of human T-cell leukemia virus
            type I
  JOURNAL   AIDS Res Hum Retroviruses 9 (2), 115-121 (1993)
   PUBMED   8457378
REFERENCE   9  (bases 1 to 921)
  AUTHORS   Nika,H. and Hultin,T.
  TITLE     Location of the sulfhydryl groups involved in disulfide interaction
            between the neighboring proteins L6 and L29 in mammalian ribosomes.
            S-cleavage of the cyanylated proteins in polyacrylamide gels after
            separation by dodecylsulfate gel electrophoresis
  JOURNAL   Eur J Biochem 142 (3), 521-526 (1984)
   PUBMED   6468376
REFERENCE   10 (bases 1 to 921)
  AUTHORS   Todokoro,K., Ulbrich,N., Chan,Y.L. and Wool,I.G.
  TITLE     Characterization of the binding of rat liver ribosomal proteins L6,
            L8, L19, S9, and S13 to 5.8 S ribosomal ribonucleic acid
  JOURNAL   J Biol Chem 256 (14), 7207-7212 (1981)
   PUBMED   7251593
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC004138.2 and AI583261.1.
            
            On Aug 13, 2020 this sequence version replaced NM_000970.5.
            
            Summary: This gene encodes a protein component of the 60S ribosomal
            subunit. This protein can bind specifically to domain C of the
            tax-responsive enhancer element of human T-cell leukemia virus type
            1, and may participate in tax-mediated transactivation of
            transcription. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            throughout the genome. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (2) is the predominant variant.
            Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020679.1, AK311863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155974 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000202773.14/ ENSP00000202773.9
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-920               BC004138.2         13-932
            921-921             AI583261.1         234-234
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..921
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /note="ribosomal protein L6"
                     /db_xref="GeneID:6128"
                     /db_xref="HGNC:HGNC:10362"
                     /db_xref="MIM:603703"
     exon            1..19
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..886
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /note="isoform 1 is encoded by transcript variant 2; 60S
                     ribosomal protein L6; tax-responsive enhancer
                     element-binding protein 107; DNA-binding protein
                     TAXREB107; neoplasm-related protein C140; large ribosomal
                     subunit protein eL6"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL6 isoform 1"
                     /protein_id="NP_000961.2"
                     /db_xref="CCDS:CCDS9162.1"
                     /db_xref="GeneID:6128"
                     /db_xref="HGNC:HGNC:10362"
                     /db_xref="MIM:603703"
                     /translation="MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHC
                     SRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNG
                     GTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGK
                     RVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFK
                     KKKLRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFA
                     LTNGIYPHKLVF"
     exon            20..256
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..355
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..499
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..548
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..733
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..921
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      903..908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /note="hexamer: ATTAAA"
     polyA_site      921
                     /gene="RPL6"
                     /gene_synonym="eL6; L6; SHUJUN-2; TAXREB107; TXREB1"
                     /note="major polyA site"
ORIGIN      
        1 ctctttccca tcttgcaaga tggcgggtga aaaagttgag aagccagata ctaaagagaa
       61 gaaacccgaa gccaagaagg ttgatgctgg tggcaaggtg aaaaagggta acctcaaagc
      121 taaaaagccc aagaagggga agccccattg cagccgcaac cctgtccttg tcagaggaat
      181 tggcaggtat tcccgatctg ccatgtattc cagaaaggcc atgtacaaga ggaagtactc
      241 agccgctaaa tccaaggttg aaaagaaaaa gaaggagaag gttctcgcaa ctgttacaaa
      301 accagttggt ggtgacaaga acggcggtac ccgggtggtt aaacttcgca aaatgcctag
      361 atattatcct actgaagatg tgcctcgaaa gctgttgagc cacggcaaaa aacccttcag
      421 tcagcacgtg agaaaactgc gagccagcat tacccccggg accattctga tcatcctcac
      481 tggacgccac aggggcaaga gggtggtttt cctgaagcag ctggctagtg gcttattact
      541 tgtgactgga cctctggtcc tcaatcgagt tcctctacga agaacacacc agaaatttgt
      601 cattgccact tcaaccaaaa tcgatatcag caatgtaaaa atcccaaaac atcttactga
      661 tgcttacttc aagaagaaga agctgcggaa gcccagacac caggaaggtg agatcttcga
      721 cacagaaaaa gagaaatatg agattacgga gcagcgcaag attgatcaga aagctgtgga
      781 ctcacaaatt ttaccaaaaa tcaaagctat tcctcagctc cagggctacc tgcgatctgt
      841 gtttgctctg acgaatggaa tttatcctca caaattggtg ttctaaatgt cttaagaacc
      901 taattaaata gctgactaca t
//
