LOCUS       NM_000969               1028 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens ribosomal protein L5 (RPL5), transcript variant 1,
            mRNA.
ACCESSION   NM_000969
VERSION     NM_000969.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1028)
  AUTHORS   Hu,X., Li,F., Zhou,Y., Gan,H., Wang,T., Li,L., Long,H., Li,B. and
            Pang,P.
  TITLE     DDX24 promotes metastasis by regulating RPL5 in non-small cell lung
            cancer
  JOURNAL   Cancer Med 11 (23), 4513-4525 (2022)
   PUBMED   35864588
  REMARK    GeneRIF: DDX24 promotes metastasis by regulating RPL5 in non-small
            cell lung cancer.
REFERENCE   2  (bases 1 to 1028)
  AUTHORS   Zhang,H., Liu,J., Dang,Q., Wang,X., Chen,J., Lin,X., Yang,N.,
            Du,J., Shi,H., Liu,Y. and Han,J.
  TITLE     Ribosomal protein RPL5 regulates colon cancer cell proliferation
            and migration through MAPK/ERK signaling pathway
  JOURNAL   BMC Mol Cell Biol 23 (1), 48 (2022)
   PUBMED   36384455
  REMARK    GeneRIF: Ribosomal protein RPL5 regulates colon cancer cell
            proliferation and migration through MAPK/ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1028)
  AUTHORS   Ma,X., Li,Y. and Zhao,B.
  TITLE     Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1)
            signaling suppresses breast cancer progression via regulating
            endoplasmic reticulum stress and autophagy
  JOURNAL   Bioengineered 13 (4), 8076-8086 (2022)
   PUBMED   35293275
  REMARK    GeneRIF: Ribosomal protein L5 (RPL5)/ E2F transcription factor 1
            (E2F1) signaling suppresses breast cancer progression via
            regulating endoplasmic reticulum stress and autophagy.
REFERENCE   4  (bases 1 to 1028)
  AUTHORS   Matsumori,H., Watanabe,K., Tachiwana,H., Fujita,T., Ito,Y.,
            Tokunaga,M., Sakata-Sogawa,K., Osakada,H., Haraguchi,T., Awazu,A.,
            Ochiai,H., Sakata,Y., Ochiai,K., Toki,T., Ito,E., Goldberg,I.G.,
            Tokunaga,K., Nakao,M. and Saitoh,N.
  TITLE     Ribosomal protein L5 facilitates rDNA-bundled condensate and
            nucleolar assembly
  JOURNAL   Life Sci Alliance 5 (7), e202101045 (2022)
   PUBMED   35321919
  REMARK    GeneRIF: Ribosomal protein L5 facilitates rDNA-bundled condensate
            and nucleolar assembly.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1028)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1028)
  AUTHORS   Hirano,K., Ito,M. and Hartshorne,D.J.
  TITLE     Interaction of the ribosomal protein, L5, with protein phosphatase
            type 1
  JOURNAL   J Biol Chem 270 (34), 19786-19790 (1995)
   PUBMED   7649987
REFERENCE   7  (bases 1 to 1028)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim Biophys Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
REFERENCE   8  (bases 1 to 1028)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
REFERENCE   9  (bases 1 to 1028)
  AUTHORS   Pogue-Geile,K., Geiser,J.R., Shu,M., Miller,C., Wool,I.G.,
            Meisler,A.I. and Pipas,J.M.
  TITLE     Ribosomal protein genes are overexpressed in colorectal cancer:
            isolation of a cDNA clone encoding the human S3 ribosomal protein
  JOURNAL   Mol Cell Biol 11 (8), 3842-3849 (1991)
   PUBMED   1712897
REFERENCE   10 (bases 1 to 1028)
  AUTHORS   Steitz,J.A., Berg,C., Hendrick,J.P., La Branche-Chabot,H.,
            Metspalu,A., Rinke,J. and Yario,T.
  TITLE     A 5S rRNA/L5 complex is a precursor to ribosome assembly in
            mammalian cells
  JOURNAL   J Cell Biol 106 (3), 545-556 (1988)
   PUBMED   3279045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BP247508.1, AF113210.1 and N67963.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 9, 2018 this sequence version replaced NM_000969.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of four RNA species and approximately
            80 structurally distinct proteins. This gene encodes a member of
            the L18P family of ribosomal proteins and component of the 60S
            subunit. The encoded protein binds 5S rRNA to form a stable complex
            called the 5S ribonucleoprotein particle (RNP), which is necessary
            for the transport of nonribosome-associated cytoplasmic 5S rRNA to
            the nucleolus for assembly into ribosomes. The encoded protein may
            also function to inhibit tumorigenesis through the activation of
            downstream tumor suppressors and the downregulation of oncoprotein
            expression. Mutations in this gene have been identified in patients
            with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed
            with the small nucleolar RNA gene U21, which is located in its
            fifth intron. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            throughout the genome. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1139019.1,
                                           SRR3476690.127437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370321.8/ ENSP00000359345.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP247508.1         30-47
            19-1025             AF113210.1         1-1007
            1026-1028           N67963.1           13-15               c
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..1028
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /note="ribosomal protein L5"
                     /db_xref="GeneID:6125"
                     /db_xref="HGNC:HGNC:10360"
                     /db_xref="MIM:603634"
     exon            1..78
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..969
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L5; protein phosphatase 1,
                     regulatory subunit 135"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL18"
                     /protein_id="NP_000960.2"
                     /db_xref="CCDS:CCDS741.1"
                     /db_xref="GeneID:6125"
                     /db_xref="HGNC:HGNC:10360"
                     /db_xref="MIM:603634"
                     /translation="MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKY
                     NTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTG
                     LLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVF
                     GALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDA
                     YKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQK
                     KDRVAQKKASFLRAQERAAES"
     exon            79..148
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /inference="alignment:Splign:2.1.0"
     exon            149..264
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /inference="alignment:Splign:2.1.0"
     exon            265..399
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /inference="alignment:Splign:2.1.0"
     exon            400..602
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /inference="alignment:Splign:2.1.0"
     exon            603..780
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /inference="alignment:Splign:2.1.0"
     exon            781..869
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1028
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1006..1011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /note="hexamer: AATAAA"
     polyA_site      1025
                     /gene="RPL5"
                     /gene_synonym="L5; MSTP030; PPP1R135; uL18"
                     /note="major polyA site"
ORIGIN      
        1 ccttttccca ccccctagcg ccgctgggcc tgcaggtctc tgtcgagcag cggacgccgg
       61 tctctgttcc gcaggatggg gtttgttaaa gttgttaaga ataaggccta ctttaagaga
      121 taccaagtga aatttagaag acgacgagag ggtaaaactg attattatgc tcggaaacgc
      181 ttggtgatac aagataaaaa taaatacaac acacccaaat acaggatgat agttcgtgtg
      241 acaaacagag atatcatttg tcagattgct tatgcccgta tagaggggga tatgatagtc
      301 tgcgcagcgt atgcacacga actgccaaaa tatggtgtga aggttggcct gacaaattat
      361 gctgcagcat attgtactgg cctgctgctg gcccgcaggc ttctcaatag gtttggcatg
      421 gacaagatct atgaaggcca agtggaggtg actggtgatg aatacaatgt ggaaagcatt
      481 gatggtcagc caggtgcctt cacctgctat ttggatgcag gccttgccag aactaccact
      541 ggcaataaag tttttggtgc cctgaaggga gctgtggatg gaggcttgtc tatccctcac
      601 agtaccaaac gattccctgg ttatgattct gaaagcaagg aatttaatgc agaagtacat
      661 cggaagcaca tcatgggcca gaatgttgca gattacatgc gctacttaat ggaagaagat
      721 gaagatgctt acaagaaaca gttctctcaa tacataaaga acagcgtaac tccagacatg
      781 atggaggaga tgtataagaa agctcatgct gctatacgag agaatccagt ctatgaaaag
      841 aagcccaaga aagaagttaa aaagaagagg tggaaccgtc ccaaaatgtc ccttgctcag
      901 aagaaggatc gggtagctca aaagaaggca agcttcctca gagctcagga gcgggctgct
      961 gagagctaaa cccagcaatt ttctatgatt ttttcagata tagataataa acttatgaac
     1021 agcaacta
//
