LOCUS       NM_001035267             676 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ribosomal protein L41 (RPL41), transcript variant 2,
            mRNA.
ACCESSION   NM_001035267
VERSION     NM_001035267.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 676)
  AUTHORS   Geng,W., Ren,J., Shi,H., Qin,F., Xu,X., Xiao,S., Jiao,Y. and
            Wang,A.
  TITLE     RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via
            ATF4 degradation
  JOURNAL   J Cell Physiol 236 (3), 2214-2225 (2021)
   PUBMED   32783256
  REMARK    GeneRIF: RPL41 sensitizes retinoblastoma cells to chemotherapeutic
            drugs via ATF4 degradation.
REFERENCE   2  (bases 1 to 676)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 676)
  AUTHORS   Yang,G. and Zong,H.
  TITLE     Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic
            cholangiocarcinoma
  JOURNAL   Mol Med Rep 13 (6), 4786-4790 (2016)
   PUBMED   27082702
  REMARK    GeneRIF: Differential gene expression analysis demonstrated
            significant upregulation of PDZK1IP1, EEF1A2 and RPL41
            (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma
            samples when compared with the matched paratumor samples.
REFERENCE   4  (bases 1 to 676)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   5  (bases 1 to 676)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 676)
  AUTHORS   Go,H., Miyado,K. and Taniguchi,S.
  TITLE     Genomic structure of the human ribosomal protein L41 gene
  JOURNAL   Biochem Mol Biol Int 46 (6), 1227-1231 (1998)
   PUBMED   9891856
REFERENCE   7  (bases 1 to 676)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 676)
  AUTHORS   Lee,J.H., Kim,J.M., Kim,M.S., Lee,Y.T., Marshak,D.R. and Bae,Y.S.
  TITLE     The highly basic ribosomal protein L41 interacts with the beta
            subunit of protein kinase CKII and stimulates phosphorylation of
            DNA topoisomerase IIalpha by CKII
  JOURNAL   Biochem Biophys Res Commun 238 (2), 462-467 (1997)
   PUBMED   9299532
REFERENCE   9  (bases 1 to 676)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 676)
  AUTHORS   Klaudiny,J., von der Kammer,H. and Scheit,K.H.
  TITLE     Characterization by cDNA cloning of the mRNA of a highly basic
            human protein homologous to the yeast ribosomal protein YL41
  JOURNAL   Biochem Biophys Res Commun 187 (2), 901-906 (1992)
   PUBMED   1326959
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF673574.1, BC082759.1,
            BC064907.1 and AC034102.32.
            
            On Nov 23, 2018 this sequence version replaced NM_001035267.1.
            
            Transcript Variant: This variant (2) is the longer transcript,
            containing a unique segment in the 5' UTR, compared to variant 1.
            Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA604697.1, SRR1163658.187316.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546591.6/ ENSP00000449026.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BF673574.1         45-61
            18-538              BC082759.1         1-521
            539-541             BC064907.1         410-412
            542-676             AC034102.32        43332-43466         c
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..676
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
                     /note="ribosomal protein L41"
                     /db_xref="GeneID:6171"
                     /db_xref="HGNC:HGNC:10354"
                     /db_xref="MIM:613315"
     exon            1..167
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..233
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
                     /note="60S ribosomal protein L41; homologue of yeast
                     ribosomal protein YL41; HG12 protein; large ribosomal
                     subunit protein eL41"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS32"
                     /protein_id="NP_001030344.1"
                     /db_xref="CCDS:CCDS44919.1"
                     /db_xref="GeneID:6171"
                     /db_xref="HGNC:HGNC:10354"
                     /db_xref="MIM:613315"
                     /translation="MRAKWRKKRMRRLKRKRRKMRQRSK"
     exon            168..190
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
                     /inference="alignment:Splign:2.1.0"
     exon            191..676
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      533..538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
                     /note="hexamer: ATTAAA"
     polyA_site      541
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
                     /note="major polyA site"
     polyA_site      635
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
     regulatory      638..643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
                     /note="hexamer: TATAAA"
     polyA_site      676
                     /gene="RPL41"
                     /gene_synonym="eL41; L41"
ORIGIN      
        1 ctctcggcct tagcgccatt tttttgggtg agtgtttttt ggttcctgcg ttgggattcc
       61 gtgtacaatc catagacatc tgacctcggc acttagcatc atcacagcaa actaactgta
      121 gcctttctct ctttccctgt agaaacctct gcgccatgag agccaagtgg aggaagaagc
      181 gaatgcgcag gctgaagcgc aaaagaagaa agatgaggca gaggtccaag taaaccgcta
      241 gcttgttgca ccgtggaggc cacaggagca gaaacatgga atgccagacg ctggggatgc
      301 tggtacaagt tgtgggactg catgctactg tctagagctt gtctcaatgg atctagaact
      361 tcatcgccct ctgatcgccg atcacctctg agacccacct tgctcataaa caaaatgccc
      421 atgttggtcc tctgccctgg acctgtgaca ttctggacta tttctgtgtt tatttgtggc
      481 cgagtgtaac aaccatataa taaatcacct cttccgctgt tttagctgaa gaattaaatc
      541 atcttgtcta ttatgttttt tatggttcca tcgggtgggg gttttctgtc attagagttt
      601 gccctgtcac tacctgtgct atggagggta tcaaagctat aaaggcaaca gcccgggtta
      661 cgtggtgtgg tttgca
//
