LOCUS       NM_000968               2741 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L4 (RPL4), mRNA.
ACCESSION   NM_000968
VERSION     NM_000968.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2741)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2741)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2741)
  AUTHORS   Okuwaki,M., Saito,S., Hirawake-Mogi,H. and Nagata,K.
  TITLE     The interaction between nucleophosmin/NPM1 and the large ribosomal
            subunit precursors contribute to maintaining the nucleolar
            structure
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118879 (2021)
   PUBMED   33039556
  REMARK    GeneRIF: The interaction between nucleophosmin/NPM1 and the large
            ribosomal subunit precursors contribute to maintaining the
            nucleolar structure.
REFERENCE   4  (bases 1 to 2741)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2741)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2741)
  AUTHORS   Twiss,J.L., Smith,D.S., Chang,B. and Shooter,E.M.
  TITLE     Translational control of ribosomal protein L4 mRNA is required for
            rapid neurite regeneration
  JOURNAL   Neurobiol Dis 7 (4), 416-428 (2000)
   PUBMED   10964612
REFERENCE   7  (bases 1 to 2741)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 2741)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 2741)
  AUTHORS   Chan,Y.L., Olvera,J. and Wool,I.G.
  TITLE     The primary structures of rat ribosomal proteins L4 and L41
  JOURNAL   Biochem Biophys Res Commun 214 (3), 810-818 (1995)
   PUBMED   7575549
REFERENCE   10 (bases 1 to 2741)
  AUTHORS   Bagni,C., Mariottini,P., Annesi,F. and Amaldi,F.
  TITLE     Human ribosomal protein L4: cloning and sequencing of the cDNA and
            primary structure of the protein
  JOURNAL   Biochim Biophys Acta 1216 (3), 475-478 (1993)
   PUBMED   8268230
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from CB149679.1, BC066925.1, CA417911.1 and AC116913.6.
            
            On Nov 23, 2018 this sequence version replaced NM_000968.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L4E family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.266028.1,
                                           SRR1803611.24478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307961.11/ ENSP00000311430.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CB149679.1         1-9
            10-1438             BC066925.1         1-1429
            1439-1441           CA417911.1         18-20               c
            1442-2741           AC116913.6         68683-69982         c
FEATURES             Location/Qualifiers
     source          1..2741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2741
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /note="ribosomal protein L4"
                     /db_xref="GeneID:6124"
                     /db_xref="HGNC:HGNC:10353"
                     /db_xref="MIM:180479"
     exon            1..68
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1349
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /note="60S ribosomal protein L4; 60S ribosomal protein L1"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL4"
                     /protein_id="NP_000959.2"
                     /db_xref="CCDS:CCDS10218.1"
                     /db_xref="GeneID:6124"
                     /db_xref="HGNC:HGNC:10353"
                     /db_xref="MIM:180479"
                     /translation="MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNL
                     RKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMF
                     APTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEG
                     YKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGII
                     KAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSN
                     YNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKT
                     MRRNTILRQARNHKLRVDKAAAAAAALQAKSDEKAAVAGKKPVVGKKGKKAAVGVKKQ
                     KKPLVGKKAAATKKPAPEKKPAEKKPTTEEKKPAA"
     exon            69..240
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     exon            241..347
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     exon            348..486
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     exon            487..611
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     exon            612..741
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     exon            742..898
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     exon            899..982
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1103
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..2741
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1417..1422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /note="hexamer: ATTATA"
     polyA_site      1441
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /note="major polyA site"
     polyA_site      1502
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /note="hexamer: AGTAAA"
     polyA_site      1795
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /note="hexamer: CATAAA"
     polyA_site      2293
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
                     /note="hexamer: ATTAAA"
     polyA_site      2741
                     /gene="RPL4"
                     /gene_synonym="L4; uL4"
ORIGIN      
        1 aagcacttcc ttttcctgtg gcagcagccg ggctgagagg agcgtggctg tctcctctct
       61 ccgccatggc gtgtgctcgc ccactgatat cggtgtactc cgaaaagggg gagtcatctg
      121 gcaaaaatgt cactttgcct gctgtattca aggctcctat tcgaccagat attgtgaact
      181 ttgttcacac caacttgcgc aaaaacaaca gacagcccta tgctgtcagt gaattagcag
      241 gtcatcagac tagtgctgag tcttggggta ctggcagagc tgtggctcga attcccagag
      301 ttcgaggtgg tgggactcac cgctctggcc agggtgcttt tggaaacatg tgtcgtggag
      361 gccgaatgtt tgcaccaacc aaaacctggc gccgttggca tcgtagagtg aacacaaccc
      421 aaaaacgata cgccatctgt tctgccctgg ctgcctcagc cctaccagca ctggtcatgt
      481 ctaaaggtca tcgtattgag gaagttcctg aacttccttt ggtagttgaa gataaagttg
      541 aaggctacaa gaagaccaag gaagctgttt tgctccttaa gaaacttaaa gcctggaatg
      601 atatcaaaaa ggtctatgcc tctcagcgaa tgagagctgg caaaggcaaa atgagaaacc
      661 gtcgccgtat ccagcgcagg ggcccgtgca tcatctataa tgaggataat ggtatcatca
      721 aggccttcag aaacatccct ggaattactc tgcttaatgt aagcaagctg aacattttga
      781 agcttgctcc tggtgggcat gtgggacgtt tctgcatttg gactgaaagt gctttccgga
      841 agttagatga attgtacggc acttggcgta aagccgcttc cctcaagagt aactacaatc
      901 ttcccatgca caagatgatt aatacagatc ttagcagaat cttgaaaagc ccagagatcc
      961 aaagagccct tcgagcacca cgcaagaaga tccatcgcag agtcctaaag aagaacccac
     1021 tgaaaaactt gagaatcatg ttgaagctaa acccatatgc aaagaccatg cgccggaaca
     1081 ccattcttcg ccaggccagg aatcacaagc tccgggtgga taaggcagct gctgcagcag
     1141 cggcactaca agccaaatca gatgagaagg cggcggttgc aggcaagaag cctgtggtag
     1201 gtaagaaagg aaagaaggct gctgttggtg ttaagaagca gaagaagcct ctggtgggaa
     1261 aaaaggcagc agctaccaag aaaccagccc ctgaaaagaa gcctgcagag aagaaaccta
     1321 ctacagagga gaagaagcct gctgcataaa ctcttaaatt tgattattcc ataaaggtca
     1381 aatcattttg gacagcttct tttgaataaa gacctgatta tacaggcagt gagaaacatg
     1441 acttggtgtg ctctgtaaag cttggttaga atttttttaa agtgacattt tgttggccat
     1501 aatttagact gttacatttt atatagtgtg gtataaaatg gggcatggat ttatactaag
     1561 tccatggagt tcagtggaag gggaatgatt taaaaaaagt tgtggttttc taaataatgt
     1621 ggcttgaaaa ataggtgtaa caggacttgg tcagaaacgc agaggctgtt caagtttagc
     1681 tccccaccag atggaaaata ggttaaattc tgtaaagatt taactttaac cacaagaggg
     1741 cacaactgga gagcacaatt tttttggtac tgcagtaaaa ttgattacct cttgagaagt
     1801 gttcttttta accagctata acaatagagt tgagtatttt cacccatggt ttgaaaaagt
     1861 gccagaaggc cacactggcc cacatctgta atcccaacac tttgggaccc taaggtgggc
     1921 agagcacttg agccaatgag ttcaagacca gcctggtcaa catgatgaaa tctcgtctct
     1981 actgaaaata taaaaaatag ccagtcatgg tgcatgcctg taaccccagc tacttggagg
     2041 ctgaggcaag agaatcactt gaacctggga ggtggaggtt gcaatgagcc aagattgtac
     2101 cattgccctc cagcctgggc gtcagagcaa gactctctga aaagtaccag aagcattttt
     2161 caggactgcc tgtgtgtctt ggtgattatg ttaaccaact gtgttcaaaa gaagtaccca
     2221 tgaaatgcct ccagatataa gggtgttttt ttttacccat aaagctaaac tgcaaatatt
     2281 accctagaat taacctcttg tcctgtgtca aaagtcttgt tttgcatctg gattgttaaa
     2341 ctgtcagctt ctctctgaca gtctcgaact gtcaagacag tctcagttca cagccaaggt
     2401 gatctgttaa ccctccccat ttccagggcc aaatctcagt tcttaagcac gtcgtttctt
     2461 agcacggctt tattttcatg ctctttattt ctctattttg tgcagcctta cccctttaaa
     2521 gtccactgtg agtcctaccc tgcagggcct cttaacacag tagagttcat gtgctactga
     2581 tttggtgcct gccttcaaac acatgtgcaa gttttgtggg gttaaagata gccacttggt
     2641 ggcacaccac attggaagtg ctgttcaccc ggtcatttga aacggtgttt gaccacttgg
     2701 tgcgcaaatg gcctatcgga ttaaaggata gccaaaccca a
//
