LOCUS       NM_005061               2145 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L3 like (RPL3L), mRNA.
ACCESSION   NM_005061
VERSION     NM_005061.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Bajpai,A.K., Gu,Q., Orgil,B.O., Alberson,N.R., Towbin,J.A.,
            Martinez,H.R., Lu,L. and Purevjav,E.
  TITLE     Exploring the Regulation and Function of Rpl3l in the Development
            of Early-Onset Dilated Cardiomyopathy and Congestive Heart Failure
            Using Systems Genetics Approach
  JOURNAL   Genes (Basel) 15 (1), 53 (2023)
   PUBMED   38254943
  REMARK    GeneRIF: Exploring the Regulation and Function of Rpl3l in the
            Development of Early-Onset Dilated Cardiomyopathy and Congestive
            Heart Failure Using Systems Genetics Approach.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Kapp,L.D. and Lorsch,J.R.
  TITLE     The molecular mechanics of eukaryotic translation
  JOURNAL   Annu Rev Biochem 73, 657-704 (2004)
   PUBMED   15189156
  REMARK    Review article
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Mazumder,B., Sampath,P., Seshadri,V., Maitra,R.K., DiCorleto,P.E.
            and Fox,P.L.
  TITLE     Regulated release of L13a from the 60S ribosomal subunit as a
            mechanism of transcript-specific translational control
  JOURNAL   Cell 115 (2), 187-198 (2003)
   PUBMED   14567916
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Odintsova,T.I., Muller,E.C., Ivanov,A.V., Egorov,T.A., Bienert,R.,
            Vladimirov,S.N., Kostka,S., Otto,A., Wittmann-Liebold,B. and
            Karpova,G.G.
  TITLE     Characterization and analysis of posttranslational modifications of
            the human large cytoplasmic ribosomal subunit proteins by mass
            spectrometry and Edman sequencing
  JOURNAL   J Protein Chem 22 (3), 249-258 (2003)
   PUBMED   12962325
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   8  (bases 1 to 2145)
  AUTHORS   Van Raay,T.J., Connors,T.D., Klinger,K.W., Landes,G.M. and
            Burn,T.C.
  TITLE     A novel ribosomal protein L3-like gene (RPL3L) maps to the
            autosomal dominant polycystic kidney disease gene region
  JOURNAL   Genomics 37 (2), 172-176 (1996)
   PUBMED   8921388
REFERENCE   9  (bases 1 to 2145)
  AUTHORS   Burn,T.C., Connors,T.D., Van Raay,T.J., Dackowski,W.R.,
            Millholland,J.M., Klinger,K.W. and Landes,G.M.
  TITLE     Generation of a transcriptional map for a 700-kb region surrounding
            the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis
            type 2 (TSC2) disease genes on human chromosome 16p3.3
  JOURNAL   Genome Res 6 (6), 525-537 (1996)
   PUBMED   8828041
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005363.1.
            
            On Nov 26, 2018 this sequence version replaced NM_005061.2.
            
            Summary: This gene encodes a protein that shares sequence
            similarity with ribosomal protein L3. The protein belongs to the
            L3P family of ribosomal proteins. Unlike the ubiquitous expression
            of ribosomal protein genes, this gene has a tissue-specific pattern
            of expression, with the highest levels of expression in skeletal
            muscle and heart. It is not currently known whether the encoded
            protein is a functional ribosomal protein or whether it has evolved
            a function that is independent of the ribosome. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050413.1, SRR5189655.26801.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268661.8/ ENSP00000268661.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC005363.1         56313-56373         c
            62-254              AC005363.1         55640-55832         c
            255-423             AC005363.1         54558-54726         c
            424-559             AC005363.1         52528-52663         c
            560-746             AC005363.1         48878-49064         c
            747-907             AC005363.1         48622-48782         c
            908-1009            AC005363.1         48309-48410         c
            1010-1105           AC005363.1         47519-47614         c
            1106-1225           AC005363.1         47183-47302         c
            1226-2145           AC005363.1         45658-46577         c
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2145
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /note="ribosomal protein L3 like"
                     /db_xref="GeneID:6123"
                     /db_xref="HGNC:HGNC:10351"
                     /db_xref="MIM:617416"
     exon            1..61
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1282
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /note="60S ribosomal protein L3-like; large ribosomal
                     subunit protein uL3-like"
                     /codon_start=1
                     /product="ribosomal protein uL3-like"
                     /protein_id="NP_005052.1"
                     /db_xref="CCDS:CCDS10450.1"
                     /db_xref="GeneID:6123"
                     /db_xref="HGNC:HGNC:10351"
                     /db_xref="MIM:617416"
                     /translation="MSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRDDPSQPVHLT
                     AFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSF
                     KTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDTDGKKQLQKDFAAMKKYCKVI
                     RVIVHTQMKLLPFRQKKAHIMEIQLNGGTVAEKVAWAQARLEKQVPVHSVFSQSEVID
                     VIAVTKGRGVKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHH
                     RTELNKKIFRIGRGPHMEDGKLVKNNASTSYDVTAKSITPLGGFPHYGEVNNDFVMLK
                     GCIAGTKKRVITLRKSLLVHHSRQAVENIELKFIDTTSKFGHGRFQTAQEKRAFMGPQ
                     KKHLEKETPETSGDL"
     exon            62..254
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            255..423
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            424..559
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            560..746
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            747..907
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1009
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1105
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1225
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..2145
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1540
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /note="major polyA site"
     polyA_site      1548
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
     regulatory      2128..2133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /note="hexamer: ATTAAA"
     polyA_site      2145
                     /gene="RPL3L"
                     /gene_synonym="CMD2D"
                     /note="major polyA site"
ORIGIN      
        1 actcgacctc tggcggctag cggcgaggcc ccttcctgac cttcagggat cggccaccat
       61 gtcccaccgg aagttttccg cccctcggca cggacacctg ggcttcctgc cccataagag
      121 gagccaccgg caccggggca aggtgaagac gtggccgcgg gatgacccca gccagcccgt
      181 gcacctcacg gccttcctgg gctacaaggc gggcatgacc cacaccctgc gggaggtgca
      241 ccggccgggg ctcaaaattt ccaaacggga ggaggtggag gcggtgacaa ttgtagaaac
      301 gccgccccta gtggtggtgg gcgtggtggg ctacgtggcc acccctcgag gtctccggag
      361 cttcaagacc atctttgcag aacacctcag tgatgagtgc cggcgccgat tctacaagga
      421 ctggcacaag agcaagaaga aagccttcac caaggcctgc aagaggtggc gggacacaga
      481 cgggaaaaag cagctacaga aggacttcgc cgccatgaag aagtactgca aggtcattcg
      541 ggtcattgtc cacactcaga tgaaactgct gcccttccgg cagaagaagg cccacatcat
      601 ggagatccag ctgaacggtg gcacggtggc cgagaaggtg gcctgggccc aggcccggct
      661 ggagaagcag gtgcccgtgc acagcgtgtt cagccagagt gaggtcattg atgtcattgc
      721 tgtcaccaag ggtcgaggcg tcaaaggggt cacaagccgc tggcatacca agaagctgcc
      781 gcggaagacc cataagggcc tgcgcaaggt ggcctgcatt ggcgcctggc accccgcccg
      841 cgtgggctgc tccattgctc gggccgggca gaagggctat caccaccgca cggagctcaa
      901 caagaagatc ttccgcatcg gcaggggccc gcacatggag gacgggaagc tggtgaagaa
      961 caatgcatcc accagctacg acgtgactgc caagtccatc acaccgctgg gtggcttccc
     1021 ccactacggg gaagtgaaca acgacttcgt catgctgaag ggttgtattg ctggtaccaa
     1081 gaagcgggtc attacgctga gaaagtccct cctggtgcat cacagtcgcc aagccgtgga
     1141 gaatattgag ctcaagttca ttgacaccac ctccaagttc ggccatggcc gcttccagac
     1201 agcccaagag aagagggcct tcatgggccc ccaaaagaag catctggaga aggaaacgcc
     1261 ggagacctcg ggagacttgt aggctgtgtg gggtggatga accctgaagc gcaccgcact
     1321 gtctgcccca atgtctaaca aaggccggag gcgactcttc ctgcgaggtc tcagagcgct
     1381 gtgtaaccgc ccaaggggtt caccttgcct gctgcctaga caaagccgat tcattaagac
     1441 aggggaattg caatagagaa agagtaattc acacagagct ggctgtgcgg gagaccggag
     1501 ttttatgttt tattattact caaatcgatc tctttgagca tttgcggagc agaggttttt
     1561 tttttttttt tttttgagag agtcttgatc ttgtcgccca ggctgctgga gtgccgggga
     1621 gcagagtttt taaggataac ttggcgggtg gggagagcca gtgagccagg agagccgatt
     1681 ggtcagggag gaaatcacag ggagtcagct gtcttcttgc gctgagtcag ctcctgggtg
     1741 gtggccacaa gatcagatga gccagtttat caatctggtt ggtgccagca gatccatcaa
     1801 gttgcagggt cggcaaaata tctcaagcac tgatcttagg ggcagcttag ggagggtcag
     1861 aatcttgtag cctccagatg cacgactcct aaaccataat tcccaatatt gtggctaatg
     1921 ttagtcctaa aaatgcaatc tagtccccag gcaaggaggt ggtctgcttt gggaaagggc
     1981 tgttactgtc tttgttttaa actataaact ggctgggcgc ggtggctcac gcctgtaatc
     2041 ccagcacttt gggaggccaa gatgggcgga tcacctgagg tcgggagttc aagaccagcc
     2101 tggccaacat cgagaaacct cgtctctatt aaaaatacaa aatta
//
