LOCUS       NM_052969                729 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L39 like (RPL39L), mRNA.
ACCESSION   NM_052969
VERSION     NM_052969.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 729)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 729)
  AUTHORS   Ye,Q., Ding,S.F., Wang,Z.A., Feng,J. and Tan,W.B.
  TITLE     Influence of ribosomal protein L39-L in the drug resistance
            mechanisms of lacrimal gland adenoid cystic carcinoma cells
  JOURNAL   Asian Pac J Cancer Prev 15 (12), 4995-5000 (2014)
   PUBMED   24998577
  REMARK    GeneRIF: High RPL39L expression is associated with drug-resistant
            lacrimal gland adenoid cystic carcinoma.
REFERENCE   3  (bases 1 to 729)
  AUTHORS   Liu,H.S., Tan,W.B., Yang,N., Yang,Y.Y., Cheng,P., Liu,L.J.,
            Wang,W.J. and Zhu,C.L.
  TITLE     Effects of ribosomal protein l39-L on the drug resistance
            mechanisms of lung cancer A549 cells
  JOURNAL   Asian Pac J Cancer Prev 15 (7), 3093-3097 (2014)
   PUBMED   24815453
  REMARK    GeneRIF: The ribosomal protein L39-L gene may have effects on the
            drug resistance mechanism of lung cancer A549 cells.
REFERENCE   4  (bases 1 to 729)
  AUTHORS   Wong,Q.W., Li,J., Ng,S.R., Lim,S.G., Yang,H. and Vardy,L.A.
  TITLE     RPL39L is an example of a recently evolved ribosomal protein
            paralog that shows highly specific tissue expression patterns and
            is upregulated in ESCs and HCC tumors
  JOURNAL   RNA Biol 11 (1), 33-41 (2014)
   PUBMED   24452241
  REMARK    GeneRIF: Results show the RP paralog Rpl39l is highly expressed in
            Embryonic Stem Cells and its expression strongly correlates with
            hepatocellular carcinoma tumor (HCC) samples with high tumor
            grading and alpha-fetoprotein level giving it diagnostic potential.
REFERENCE   5  (bases 1 to 729)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 729)
  AUTHORS   Uechi,T., Maeda,N., Tanaka,T. and Kenmochi,N.
  TITLE     Functional second genes generated by retrotransposition of the
            X-linked ribosomal protein genes
  JOURNAL   Nucleic Acids Res 30 (24), 5369-5375 (2002)
   PUBMED   12490704
REFERENCE   7  (bases 1 to 729)
  AUTHORS   Nadano,D., Notsu,T., Matsuda,T. and Sato,T.
  TITLE     A human gene encoding a protein homologous to ribosomal protein L39
            is normally expressed in the testis and derepressed in multiple
            cancer cells
  JOURNAL   Biochim Biophys Acta 1577 (3), 430-436 (2002)
   PUBMED   12359333
  REMARK    GeneRIF: locus, structure and expression of the gene and its
            relevance to the biological activities of the ribosome
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM769958.1, BC012328.1 and
            BU674063.1.
            
            On Nov 23, 2018 this sequence version replaced NM_052969.2.
            
            Summary: This gene encodes a protein sharing high sequence
            similarity with ribosomal protein L39. Although the name of this
            gene has been referred to as 'ribosomal protein L39' in the public
            databases, its official name is 'ribosomal protein L39-like'. It is
            not currently known whether the encoded protein is a functional
            ribosomal protein or whether it has evolved a function that is
            independent of the ribosome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.287879.1,
                                           SRR5189661.160828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296277.9/ ENSP00000296277.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BM769958.1         28-48
            22-724              BC012328.1         1-703
            725-729             BU674063.1         14-18               c
FEATURES             Location/Qualifiers
     source          1..729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..729
                     /gene="RPL39L"
                     /gene_synonym="L39-2; RPL39L1"
                     /note="ribosomal protein L39 like"
                     /db_xref="GeneID:116832"
                     /db_xref="HGNC:HGNC:17094"
                     /db_xref="MIM:607547"
     exon            1..284
                     /gene="RPL39L"
                     /gene_synonym="L39-2; RPL39L1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..348
                     /gene="RPL39L"
                     /gene_synonym="L39-2; RPL39L1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..729
                     /gene="RPL39L"
                     /gene_synonym="L39-2; RPL39L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..532
                     /gene="RPL39L"
                     /gene_synonym="L39-2; RPL39L1"
                     /note="ribosomal protein L39-like 1; ribosomal protein
                     L39-like protein; 60S ribosomal protein L39-like; 60S
                     ribosomal protein L39-2; large ribosomal subunit protein
                     eL39-like"
                     /codon_start=1
                     /product="ribosomal protein eL39-like 2"
                     /protein_id="NP_443201.1"
                     /db_xref="CCDS:CCDS3286.1"
                     /db_xref="GeneID:116832"
                     /db_xref="HGNC:HGNC:17094"
                     /db_xref="MIM:607547"
                     /translation="MSSHKTFTIKRFLAKKQKQNRPIPQWIQMKPGSKIRYNSKRRHW
                     RRTKLGL"
     regulatory      699..704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL39L"
                     /gene_synonym="L39-2; RPL39L1"
                     /note="hexamer: AATAAA"
     polyA_site      729
                     /gene="RPL39L"
                     /gene_synonym="L39-2; RPL39L1"
                     /note="major polyA site"
ORIGIN      
        1 gcggtcttag catccggcgc gcggcggttg aattgctgcg cccagcgagg caaccgcctc
       61 cgaacgccag gtgggggcga ggcgtctcgg agtctcagag acaccaaggc ccctgcgaca
      121 aggtggctgc agctaggccg ggggcgtcag gacgacggag cgggttcggg tcggtgacac
      181 gcagacctga gggagctggg cccgcctttt ccgcccgcgc cccaggccct tgcagatcga
      241 gatttgcgtc ctagagtggg aaaaaagcag aggccagggc gccgatttta tttggagaga
      301 agcaagcatc tttgcctctt tggagtagga aattcagact tgaaaaagtg gtgtgtggtt
      361 gactctgttt ctcgccatgt cttctcacaa gactttcacc attaagcgat tcctggccaa
      421 gaaacaaaag caaaatcgtc ccatccccca gtggattcag atgaaacctg gtagtaaaat
      481 caggtacaac tccaaaagga ggcattggag aagaaccaag ctgggtctat aaggaattgc
      541 acatgagatg gcacacatat ttatgctgta tcaagttcac gatcatctta cgatatcaag
      601 ctgaaaatgt caccactacc tggacagttg cacatgtttt actgggaata tttttttctg
      661 tttttctgta tgctctgtgc tagtagggtg gattcagtaa taaatatgtg aaagcttttg
      721 tttcaaaaa
//
