LOCUS       NM_001000                390 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ribosomal protein L39 (RPL39), mRNA.
ACCESSION   NM_001000
VERSION     NM_001000.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 390)
  AUTHORS   Sun,F., Wei,Y., Liu,Z., Jie,Q., Yang,X., Long,P., Wang,J.,
            Xiong,Y., Li,Q., Quan,S. and Ma,Y.
  TITLE     Acylglycerol kinase promotes ovarian cancer progression and
            regulates mitochondria function by interacting with ribosomal
            protein L39
  JOURNAL   J Exp Clin Cancer Res 41 (1), 238 (2022)
   PUBMED   35934718
  REMARK    GeneRIF: Acylglycerol kinase promotes ovarian cancer progression
            and regulates mitochondria function by interacting with ribosomal
            protein L39.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 390)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 390)
  AUTHORS   Dave,B., Gonzalez,D.D., Liu,Z.B., Li,X., Wong,H., Granados,S.,
            Ezzedine,N.E., Sieglaff,D.H., Ensor,J.E., Miller,K.D., Radovich,M.,
            KarinaEtrovic,A., Gross,S.S., Elemento,O., Mills,G.B.,
            Gilcrease,M.Z. and Chang,J.C.
  TITLE     Role of RPL39 in Metaplastic Breast Cancer
  JOURNAL   J Natl Cancer Inst 109 (6), 2758642 (2016)
   PUBMED   28040796
  REMARK    GeneRIF: RPL39 mediated its cancer-promoting actions through iNOS
            signaling, which was driven by the RNA editing enzyme adenosine
            deaminase acting on RNA 1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 390)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   5  (bases 1 to 390)
  AUTHORS   Dave,B., Granados-Principal,S., Zhu,R., Benz,S., Rabizadeh,S.,
            Soon-Shiong,P., Yu,K.D., Shao,Z., Li,X., Gilcrease,M., Lai,Z.,
            Chen,Y., Huang,T.H., Shen,H., Liu,X., Ferrari,M., Zhan,M.,
            Wong,S.T., Kumaraswami,M., Mittal,V., Chen,X., Gross,S.S. and
            Chang,J.C.
  TITLE     Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in
            breast cancer by inhibiting nitric oxide synthase signaling
  JOURNAL   Proc Natl Acad Sci U S A 111 (24), 8838-8843 (2014)
   PUBMED   24876273
  REMARK    GeneRIF: RPL39 and MLF2 have roles in tumor initiation and
            metastasis in breast cancer that involve nitric oxide synthase
            signaling
REFERENCE   6  (bases 1 to 390)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   7  (bases 1 to 390)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   8  (bases 1 to 390)
  AUTHORS   Tsui,S.K., Lee,S.M., Fung,K.P., Waye,M.M. and Lee,C.Y.
  TITLE     Primary structures and sequence analysis of human ribosomal
            proteins L39 and S27
  JOURNAL   Biochem Mol Biol Int 40 (3), 611-616 (1996)
   PUBMED   8908372
REFERENCE   9  (bases 1 to 390)
  AUTHORS   Otsuka,S., Tanaka,M., Saito,S., Yoshimoto,K. and Itakura,M.
  TITLE     Molecular cloning of a cDNA encoding human ribosomal protein L39
  JOURNAL   Biochim Biophys Acta 1308 (2), 119-121 (1996)
   PUBMED   8764829
REFERENCE   10 (bases 1 to 390)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BX476041.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001000.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the S39E family of ribosomal proteins. It is located in the
            cytoplasm. In rat, the protein is the smallest, and one of the most
            basic, proteins of the ribosome. This gene is co-transcribed with
            the U69 small nucleolar RNA gene, which is located in its second
            intron. As is typical for genes encoding ribosomal proteins, there
            are multiple processed pseudogenes of this gene dispersed through
            the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.98803.1,
                                           SRR5189661.155159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361575.4/ ENSP00000355315.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               BX476041.1         31-420
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..390
                     /gene="RPL39"
                     /gene_synonym="eL39; L39; RPL39P42; RPL39_23_1806"
                     /note="ribosomal protein L39"
                     /db_xref="GeneID:6170"
                     /db_xref="HGNC:HGNC:10350"
                     /db_xref="MIM:300899"
     exon            1..57
                     /gene="RPL39"
                     /gene_synonym="eL39; L39; RPL39P42; RPL39_23_1806"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..210
                     /gene="RPL39"
                     /gene_synonym="eL39; L39; RPL39P42; RPL39_23_1806"
                     /note="60S ribosomal protein L39"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL39"
                     /protein_id="NP_000991.1"
                     /db_xref="CCDS:CCDS14586.1"
                     /db_xref="GeneID:6170"
                     /db_xref="HGNC:HGNC:10350"
                     /db_xref="MIM:300899"
                     /translation="MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHW
                     RRTKLGL"
     exon            58..161
                     /gene="RPL39"
                     /gene_synonym="eL39; L39; RPL39P42; RPL39_23_1806"
                     /inference="alignment:Splign:2.1.0"
     exon            162..390
                     /gene="RPL39"
                     /gene_synonym="eL39; L39; RPL39P42; RPL39_23_1806"
                     /inference="alignment:Splign:2.1.0"
     regulatory      363..368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL39"
                     /gene_synonym="eL39; L39; RPL39P42; RPL39_23_1806"
                     /note="hexamer: AATAAA"
     polyA_site      390
                     /gene="RPL39"
                     /gene_synonym="eL39; L39; RPL39P42; RPL39_23_1806"
                     /note="major polyA site"
ORIGIN      
        1 ccctcctctt cctttctccg ccatcgtggt gtgttcttga ctccgctgct cgccatgtct
       61 tctcacaaga ctttcaggat taagcgattc ctggccaaga aacaaaagca aaatcgtccc
      121 attccccagt ggattcggat gaaaactgga aataaaatca ggtacaactc caaaaggaga
      181 cattggagaa gaaccaagct gggtctataa ggaattgcac atgagatggc acacatattt
      241 atgctgtctg aaggtcacga tcatgttacc atatcaagct gaaaatgtca ccactatctg
      301 gagatttcga cgtgttttcc tctctgaatc tgttatgaac acgttggttg gctggattca
      361 gtaataaata tgtaaggcct ttctttttaa
//
