LOCUS       NM_000999               1145 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L38 (RPL38), transcript variant 1,
            mRNA.
ACCESSION   NM_000999
VERSION     NM_000999.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1145)
  AUTHORS   Qin,Y., Liu,L., Hu,X., Zhang,Y., Pan,Y. and Gao,H.
  TITLE     Expression and bioinformatics analysis of RPL38 protein and mRNA in
            gastric cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (13), 256-261 (2023)
   PUBMED   38158659
  REMARK    GeneRIF: Expression and bioinformatics analysis of RPL38 protein
            and mRNA in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1145)
  AUTHORS   Gopanenko,A.V., Kolobova,A.V., Meschaninova,M.I., Venyaminova,A.G.,
            Tupikin,A.E., Kabilov,M.R., Malygin,A.A. and Karpova,G.G.
  TITLE     Knockdown of the mRNA encoding the ribosomal protein eL38 in
            mammalian cells causes a substantial reorganization of genomic
            transcription
  JOURNAL   Biochimie 184, 132-142 (2021)
   PUBMED   33675855
  REMARK    GeneRIF: Knockdown of the mRNA encoding the ribosomal protein eL38
            in mammalian cells causes a substantial reorganization of genomic
            transcription.
REFERENCE   3  (bases 1 to 1145)
  AUTHORS   Gopanenko,A.V., Kolobova,A.V., Tupikin,A.E., Kabilov,M.R.,
            Malygin,A.A. and Karpova,G.G.
  TITLE     Knockdown of the Ribosomal Protein eL38 in HEK293 Cells Changes the
            Translational Efficiency of Specific Genes
  JOURNAL   Int J Mol Sci 22 (9), 4531 (2021)
   PUBMED   33926116
  REMARK    GeneRIF: Knockdown of the Ribosomal Protein eL38 in HEK293 Cells
            Changes the Translational Efficiency of Specific Genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1145)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1145)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1145)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   7  (bases 1 to 1145)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   8  (bases 1 to 1145)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   9  (bases 1 to 1145)
  AUTHORS   Espinosa,L., Martin,M., Nicolas,A., Fabre,M. and Navarro,E.
  TITLE     Primary sequence of the human, lysine-rich, ribosomal protein RPL38
            and detection of an unusual RPL38 processed pseudogene in the
            promoter region of the type-1 angiotensin II receptor gene
  JOURNAL   Biochim Biophys Acta 1354 (1), 58-64 (1997)
   PUBMED   9375793
REFERENCE   10 (bases 1 to 1145)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BQ276548.1, Z26876.1, CB124619.1 and AC100786.2.
            
            On Nov 23, 2018 this sequence version replaced NM_000999.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L38E family of ribosomal proteins. It is located in the
            cytoplasm. Alternative splice variants have been identified, both
            encoding the same protein. As is typical for genes encoding
            ribosomal proteins, there are multiple processed pseudogenes of
            this gene dispersed through the genome, including one located in
            the promoter region of the type 1 angiotensin II receptor gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer and predominant
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.54255.1, CD390038.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311111.11/ ENSP00000309830.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BQ276548.1         26-57
            33-368              Z26876.1           37-372
            369-370             CB124619.1         381-382
            371-1145            AC100786.2         51606-52380         c
FEATURES             Location/Qualifiers
     source          1..1145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1145
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /note="ribosomal protein L38"
                     /db_xref="GeneID:6169"
                     /db_xref="HGNC:HGNC:10349"
                     /db_xref="MIM:604182"
     exon            1..68
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /inference="alignment:Splign:2.1.0"
     exon            69..109
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..319
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /note="60S ribosomal protein L38"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL38"
                     /protein_id="NP_000990.1"
                     /db_xref="CCDS:CCDS11696.1"
                     /db_xref="GeneID:6169"
                     /db_xref="HGNC:HGNC:10349"
                     /db_xref="MIM:604182"
                     /translation="MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYT
                     LVITDKEKAEKLKQSLPPGLAVKELK"
     exon            110..170
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /inference="alignment:Splign:2.1.0"
     exon            171..293
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /inference="alignment:Splign:2.1.0"
     exon            294..1145
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      349..354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /note="hexamer: ATTAAA"
     polyA_site      370
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /note="major polyA site"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
                     /note="hexamer: CATAAA"
     polyA_site      1145
                     /gene="RPL38"
                     /gene_synonym="eL38; L38"
ORIGIN      
        1 ctttttcgtc cttttccccg gttgctgctt gctgtgagtg tctctagggt gatacgtggg
       61 tgagaaaggt cctggtccgc gccagagccc agcgcgcctc gtcgccatgc ctcggaaaat
      121 tgaggaaatc aaggacttcc tgctcacagc ccgacgaaag gatgccaaat ctgtcaagat
      181 caagaaaaat aaggacaacg tgaagtttaa agttcgatgc agcagatacc tttacaccct
      241 ggtcatcact gacaaagaga aggcagagaa actgaagcag tccctgcccc ccggtttggc
      301 agtgaaggaa ctgaaatgaa ccagacacac tgattggaac tgtattatat taaaatacta
      361 aaaatcctaa gtgtctttcg tctttgcgga tgggaaaggg aaaaatgcta cctcgtagtg
      421 gcttctgatg ggaacaggac gcgggttctg ttgctgcctt cctgtgtctt tttttttttt
      481 tttttttctt tctttgagac ggagtcttgc tctgtggctc atcctggagc acagtggtgc
      541 gatatcagct cactaccacc tccgcctcct gggttcaagc gactgtcctg cctcagcctc
      601 ccgagtggct gggattacag gcacacatca ccacgcctgg ccaatttttg tatttgtagt
      661 agagacaggg tttcactgcc tgcctcagcc tcccatagtg ctgggattac aggcatgagc
      721 ctccgtgccc ggtgcatccc taatcttgag catgatctca gtcggcaaat gaggccatct
      781 gttttcagcc tgtttgaaaa taagatgtgg ggaggccatg atggaaatag cacgtggggt
      841 taaacataac tggcagatgt gggagcgatg gtggggcatg ccattcaaac aggtcccaaa
      901 atgggtgcaa caaggtatag cacatctacc actcgctaac ttgactgact tggagaaatg
      961 actacacttt tgcctgtttc ctcagttgga aaatagccat attaacacct ctttcattgg
     1021 cttgctgtca gggtactggg atggggggag gtgcatgggt tggggtggcc accaggtggt
     1081 gctgtgccac agcgggcagc ccctctggaa atgactggca tcataaaatc tgtcttcata
     1141 cccga
//
