LOCUS       NM_000998               2992 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L37a (RPL37A), mRNA.
ACCESSION   NM_000998
VERSION     NM_000998.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2992)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2992)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2992)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2992)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   5  (bases 1 to 2992)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   6  (bases 1 to 2992)
  AUTHORS   Odintsova,T.I., Muller,E.C., Ivanov,A.V., Egorov,T.A., Bienert,R.,
            Vladimirov,S.N., Kostka,S., Otto,A., Wittmann-Liebold,B. and
            Karpova,G.G.
  TITLE     Characterization and analysis of posttranslational modifications of
            the human large cytoplasmic ribosomal subunit proteins by mass
            spectrometry and Edman sequencing
  JOURNAL   J Protein Chem 22 (3), 249-258 (2003)
   PUBMED   12962325
REFERENCE   7  (bases 1 to 2992)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   8  (bases 1 to 2992)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 2992)
  AUTHORS   Saha,D.P., Tirumalai,P.S., Scala,L.A. and Howells,R.D.
  TITLE     Human ribosomal protein L37a: cloning of the cDNA and analysis of
            differential gene expression in tissues and cell lines
  JOURNAL   Gene 132 (2), 285-289 (1993)
   PUBMED   8224875
REFERENCE   10 (bases 1 to 2992)
  AUTHORS   Hoof,T., Fislage,R. and Tummler,B.
  TITLE     Primary sequence of the human ribosomal protein L37a
  JOURNAL   Nucleic Acids Res 20 (20), 5475 (1992)
   PUBMED   1437567
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from CD249666.1, L06499.1, BC014262.2 and AC073321.4.
            
            On May 17, 2019 this sequence version replaced NM_000998.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L37AE family of ribosomal proteins. It is located in the
            cytoplasm. The protein contains a C4-type zinc finger-like domain.
            As is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067789.1, AU118260.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000491306.6/ ENSP00000418082.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CD249666.1         69-82
            15-328              L06499.1           1-314
            329-373             BC014262.2         313-357
            374-2992            AC073321.4         147171-149789       c
FEATURES             Location/Qualifiers
     source          1..2992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2992
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /note="ribosomal protein L37a"
                     /db_xref="GeneID:6168"
                     /db_xref="HGNC:HGNC:10348"
                     /db_xref="MIM:613314"
     exon            1..34
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..310
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /note="60S ribosomal protein L37a"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL43"
                     /protein_id="NP_000989.1"
                     /db_xref="CCDS:CCDS2404.1"
                     /db_xref="GeneID:6168"
                     /db_xref="HGNC:HGNC:10348"
                     /db_xref="MIM:613314"
                     /translation="MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGK
                     TKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ"
     exon            35..163
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /inference="alignment:Splign:2.1.0"
     exon            164..246
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /inference="alignment:Splign:2.1.0"
     exon            247..2992
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      346..351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /note="hexamer: AATAAA"
     polyA_site      373
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /note="major polyA site"
     polyA_site      458
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
     regulatory      512..517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /note="hexamer: AATATA"
     polyA_site      531
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
     regulatory      1351..1356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /note="hexamer: ATTAAA"
     polyA_site      1369
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
     regulatory      1669..1674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /note="hexamer: AGTAAA"
     polyA_site      1687
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
     polyA_site      2296
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
     polyA_site      2301
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
     regulatory      2962..2967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
                     /note="hexamer: TATAAA"
     polyA_site      2992
                     /gene="RPL37A"
                     /gene_synonym="eL43; L37A"
ORIGIN      
        1 ctttctgggc tcggacctag gtcgcggcga catggccaaa cgtaccaaga aagtcgggat
       61 cgtcggtaaa tacgggaccc gctatggggc ctccctccgg aaaatggtga agaaaattga
      121 aatcagccag cacgccaagt acacttgctc tttctgtggc aaaaccaaga tgaagagacg
      181 agctgtgggg atctggcact gtggttcctg catgaagaca gtggctggcg gtgcctggac
      241 gtacaatacc acttccgctg tcacggtaaa gtccgccatc agaagactga aggagttgaa
      301 agaccagtag acgctcctct actctttgag acatcactgg cctataataa atgggttaat
      361 ttatgtaaca aaattgcctt ggcttgttaa ctttattaga cattctgatg tttgcattgt
      421 gtaaatactg ttgtattgga aaagcatgcc aagatggatt attgtaattc agtgtctttt
      481 ttagtagtca aatggtaaaa tgcagcataa gaatataagt cttccaagtt agatatgagt
      541 gttagctttt tataagtctg ctcctgccag tttgactttg agatacattg gagccaactg
      601 taaactttag tttttaaatt acagttagtt tttttgtttg tttttgaggc ggagtctctg
      661 ttacccaggc tggagtgcag tataccagtc ttggcccact tcaacctcca cttcttaggt
      721 tcaagcgatt ctcctgcctc agcctcctga gtagctggga ttacaggcac gcaccaccat
      781 acctggctaa tttttgtatt ttgagtagag atggagtttt caccacattg gccaggctgt
      841 tcttgaactg acctcaagcg atccacctgc cttggccttc cagagtgctg ggattacagg
      901 tgtgagccac cacgcccagc cttgcattta atatttttat aatgtgtcta ggctgggtgc
      961 ggtgactcac gcctgaaatc ccagcacttt gggtggctga ggcaggtgga ttacttgagg
     1021 ccaggagatt gagaccagtg tggccaacat agcaaaaacc cgtctcgacg aaaaatacaa
     1081 aaaatagctt ggtatggtgg cacatgcctg taatcccagc tactttggag gctcaggcac
     1141 aagaatcact tgaacctacg aggcggaggt tgcagtgggc caggatcgtg ccactgcact
     1201 ttatttagcc aggacaacac tctgtctcca aaaaaaagtt tctgaaggta aaagatatac
     1261 taaaggatat acatatactg cctcttctat gatgtttcat ttgacctaca ccatcagcat
     1321 cttcaggaaa cagtatgaaa ctaatttcac attaaatgtt gcaaacgtct gcaattctcc
     1381 agtttttagt ttgcacgtaa ggattcgtag gattgatttc agattgacag atggttgtag
     1441 taacaaaaaa atgaattgcc ttggagaatt cgagttattt taggcctgcc tttgacactt
     1501 ttatgcactt aattcactgc caatttagtc taactcctca accatctgtg gtatggactt
     1561 ctcagtcctc ctaattggta tgtcttttat ctatcccaga gtcagtagtc ctttaaggat
     1621 gcaaatttaa ttcgataaga atgtggattt acttcatctt taggacagag taaaaacctt
     1681 tatttcactt ggtctgaccc ctatcttcta taacttgttt ttttgctcat tactggcctt
     1741 tgcacggatg tctcccttca cctgtacctc ctgcattgcc tctggcagaa acatcgctac
     1801 cccaggagaa tacttcactg ggtcaggcat ttgctagatc catagcagta actcatctgt
     1861 ggatctcatt tgtgtcacaa aatggtactc ctactgattt tgtaatgtga agcaagtact
     1921 gtgggtcagt aggggtagga ccaggagtga caagtcagga ttttcaggct tcataggaat
     1981 gacacagctc tccaggtgaa tctcctggag aattctccat aggatctcca ggtgagtgac
     2041 caggatttca tgtaagcata gggaattgaa tgagcattag atggtctaat gctgcggtta
     2101 agaacaccaa cttagccaaa ctgcctagat agttgggtga cttgggttaa gtgacttaac
     2161 ctctctgctt cagtttcctg tataattctt ggtagtagaa tggagtatat gctgggtgtt
     2221 tggattatta atttggagtc ttacaaagct gctatgttac atgattaggc atggaaaact
     2281 tcggttttta taatcagtga agtactgctt tttgtttgtt ttctgagaga gtgtctgtca
     2341 cccaggctga agtgcagtgg catgatctca gttcactgca gcctctacct cccgggttca
     2401 agcagttctc gtgcctcagc ctccgaagta gctgggatta caggcttatg ccacaaagct
     2461 cagctagttt ttgtattttt tatttttagt agagatgggc tttcgccatg ttgaccaggc
     2521 tggtctcaaa ctcccaggct caactgataa cgtctgcctt ggcctcccaa agtgctggga
     2581 ttctgtaagc cacctcaccc agccatgtat tgctttttta tgacagttaa aagaggaaag
     2641 ggcgggggac agtttacaga ccagtgaaag tgctgagata aatattttta tacctaagga
     2701 aatagtgatt ttcccaagat gatagggagg caggtgatgt agatagggct gaagattaga
     2761 tttctggctc ctatctgtga ttttctgctg taccagtctg ccttctattt tatgggctca
     2821 gtattcctta cctgcctctt cccatgctaa agatggccca ccttcgtttt gttatttaag
     2881 caacttcatc ccctggcttg ttttcacagt ggttttctga gcctttgact ctaagtcatc
     2941 taattgaaca ttgtgttgtg atataaaaag taagttaggc ttgtgttttt ca
//
