LOCUS       NM_000997               7573 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ribosomal protein L37 (RPL37), transcript variant 1,
            mRNA.
ACCESSION   NM_000997 NR_037665 XR_108574 XR_112729 XR_113736
VERSION     NM_000997.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7573)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7573)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   3  (bases 1 to 7573)
  AUTHORS   Daftuar,L., Zhu,Y., Jacq,X. and Prives,C.
  TITLE     Ribosomal proteins RPL37, RPS15 and RPS20 regulate the
            Mdm2-p53-MdmX network
  JOURNAL   PLoS One 8 (7), e68667 (2013)
   PUBMED   23874713
  REMARK    GeneRIF: RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network
            but employ different mechanisms to do so.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7573)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   5  (bases 1 to 7573)
  AUTHORS   Llanos,S. and Serrano,M.
  TITLE     Depletion of ribosomal protein L37 occurs in response to DNA damage
            and activates p53 through the L11/MDM2 pathway
  JOURNAL   Cell Cycle 9 (19), 4005-4012 (2010)
   PUBMED   20935493
  REMARK    GeneRIF: Data report that depletion of L37 leads to cell cycle
            arrest in a MDM2/L11- and p53-dependent manner.
REFERENCE   6  (bases 1 to 7573)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   7  (bases 1 to 7573)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 7573)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 7573)
  AUTHORS   Su,S. and Bird,R.C.
  TITLE     Cell cycle, differentiation and tissue-independent expression of
            ribosomal protein L37
  JOURNAL   Eur J Biochem 232 (3), 789-797 (1995)
   PUBMED   7588717
REFERENCE   10 (bases 1 to 7573)
  AUTHORS   Barnard,G.F., Staniunas,R.J., Puder,M., Steele,G.D. Jr. and
            Chen,L.B.
  TITLE     Human ribosomal protein L37 has motifs predicting serine/threonine
            phosphorylation and a zinc-finger domain
  JOURNAL   Biochim Biophys Acta 1218 (3), 425-428 (1994)
   PUBMED   7545944
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC008810.8.
            
            On or before Nov 30, 2018 this sequence version replaced
            NR_037665.1, NM_000997.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L37E family of ribosomal proteins. It is located in the
            cytoplasm. The protein contains a C2C2-type zinc finger-like motif.
            As is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.490308.1,
                                           SRR3476690.779581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274242.10/ ENSP00000274242.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC008810.8         8544-8583
            41-176              AC008810.8         9160-9295
            177-261             AC008810.8         9501-9585
            262-7573            AC008810.8         11193-18504
FEATURES             Location/Qualifiers
     source          1..7573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..7573
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /note="ribosomal protein L37"
                     /db_xref="GeneID:6167"
                     /db_xref="HGNC:HGNC:10347"
                     /db_xref="MIM:604181"
     exon            1..40
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..331
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /note="60S ribosomal protein L37; 60S ribosomal protein
                     L37a; G1.16"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL37"
                     /protein_id="NP_000988.1"
                     /db_xref="CCDS:CCDS3934.1"
                     /db_xref="GeneID:6167"
                     /db_xref="HGNC:HGNC:10347"
                     /db_xref="MIM:604181"
                     /translation="MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRK
                     RKYNWSAKAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPKRAAVAASSSS"
     exon            41..176
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /inference="alignment:Splign:2.1.0"
     exon            177..261
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /inference="alignment:Splign:2.1.0"
     exon            262..7573
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      354..359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /note="hexamer: AATAAA"
     polyA_site      379
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /note="major polyA site"
     regulatory      6486..6491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /note="hexamer: AATAAT"
     polyA_site      6510
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
     regulatory      7551..7556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
                     /note="hexamer: AATAAA"
     polyA_site      7573
                     /gene="RPL37"
                     /gene_synonym="eL37; L37"
ORIGIN      
        1 ctcttccggt ctttctggtc tcggccgcag aagcgagatg acgaagggaa cgtcatcgtt
       61 tggaaagcgt cgcaataaga cgcacacgtt gtgccgccgc tgtggctcta aggcctacca
      121 ccttcagaag tcgacctgtg gcaaatgtgg ctaccctgcc aagcgcaaga gaaagtataa
      181 ctggagtgcc aaggctaaaa gacgaaatac caccggaact ggtcgaatga ggcacctaaa
      241 aattgtatac cgcagattca ggcatggatt ccgtgaagga acaacaccta aacccaagag
      301 ggcagctgtt gcagcatcca gttcatctta agaatgtcaa cgattagtca tgcaataaat
      361 gttctggttt taaaaaatac atatctggtt ttggtaaggt atttttaatc aattaggctt
      421 gtagtatcag tgaaatactg taggtttagg gactgggcta gcttcatatc agatttactt
      481 gttaagtgac tgttttggaa tgtttacttt tggactgggt ttgtaacacg gttaaaggca
      541 atgagaaaca agcagaattc caggagtcct tgaagcagag ggcactggaa gacaatatag
      601 cagattaaaa tagcacagct catgtggcat aggtgggtat tttagatgtt tgagtaaatt
      661 tgaaagagta tgatgtttaa attaccttta gcaacatgtt catctgctat gctgtcatga
      721 ctagggggat gattattagt cacatagagc ttgggagtac cactggaaac gtatgggtag
      781 gagtttaggt ggcttctgtt tttcaaaaga tgatcttatc ctagtatctg taatgctcac
      841 ttggcacacc tgacttgtgg gctgtgtgta aggtggctag ctaagtgaaa aaagcctgct
      901 aggtgtgagt caacttaaga atatgtaaat aggtttgaga aaaagtaggg cttgggtgca
      961 agtaaagatt gagcaggaaa taaaggaaaa tcaagtataa tccctgagat ttgtagacta
     1021 aaggcaatga tgtgggacta cttggtcgaa tttttttagc cctcaacttg gtaattgggt
     1081 gtttctgtgt taaagcactg aaacttgctg tcgtgccttc ctagttttcg tggtttattg
     1141 acagggttgg gggttttttt tgttttttta aaatgaaggg acaaagtcaa ctggactgct
     1201 gagtgagagg gcaggggcag ttgaagggaa catgaattgc tggaacagct acataaaata
     1261 gtgatgtagc caagtcatgc tatttaaatt ataattctcc actgtgttta gaataacatc
     1321 tgaggttctt aacctggcct tggaagggta tcacttttac ttgtaacctg gaatggcttt
     1381 ataatgtgct agctaattgc tactctcatc ttgtatttta actcctaatt tacccttcag
     1441 gtctcagctt cagaacattc acttataaag aaaccctgct gattaaatct ctcttgggct
     1501 tcctcccgaa atgtgagact atactttaaa gatgtatggt tagagtccaa ttgccattgc
     1561 ctttcttgtt tacagatagt gcaatggcgc aatcctggct cactgcagcc tctaattcct
     1621 gggctcaagt caagtggttc tcctgcctca gccttctgag tagctgggac tacagatgca
     1681 caccaccaca cctggctaat ttttgtgttt tttgtagaga tggagattca ctcgactaat
     1741 tctttttgta ttcttagtag agactgggtt tcaacatgtt gaccaggctg gtctcgaact
     1801 cgacctcgtg atccgccgcc tcggcctccc aaagtgctag gattacaggc gtgagccacc
     1861 actcccggct gtcatcatca aattttcaag tgaagatagt ctgttgaaga ttgaacaatg
     1921 accttgaaag acagctgagt tgctgtgggt ataatgtaaa gctggtgaag tttggccagt
     1981 ttgggcttca gaagtctaag tctagtgaag gtaccctgac ccccatataa acaacccttg
     2041 aggccggtgt ggtggctcac ggctgtaatc ctggcacttt gggaggccga ggtgggcgga
     2101 tcacaaggtc aagagatcga gatcaccctg gcccacatgg tgagacccca actctactaa
     2161 aaatacaaaa attagctggg tgtggtggca tgtgcctgta gtcttagcta cttgagaggc
     2221 tgaggcagga gaatcgcttg aacctgggag gcagaggttg cagtgagctg agatcatgcc
     2281 actgtgctcc agcctggtgg cacagtgaga ctccacctca aaaaaaaaaa aaaatccttg
     2341 aactaatgac tcaaattttc aaatgaaaca aaataagcag tggatcttgc attggagatg
     2401 gagttaaact atgttgccca ggctggtctt ggactcctgg tttcaagtga tcctctcatc
     2461 ttggcctccc aaagtgctgg gattacaggg acgagccacc acaccccacc tattgtctat
     2521 atttctatct ttaacagcac ttcagtcctg ccttaagtta tagttatgta tagataccca
     2581 ttatacttta aatttttcag cagaaattat gcttttatct tctctgcagt gttatatgtt
     2641 ggtgtgcaaa aatgttaaat ttatttttcc taagtacccc atctgctttt caactctgtc
     2701 ctctgcctga aaagcctccc tccagcccct acttccctcc catcttagtt cacaaagtca
     2761 ggttgatttg cccccagctg tcaaagcaga ctacctgttt ccacatgtaa ctggttatgt
     2821 tctgtaaagt tacaaaaata gaaaggttga atctgtggcg gccgggtacg gtagctcacg
     2881 tcctatagtc gcagcacttt gggaggccaa ggtgggcagt tcacgtgagg tggggagttc
     2941 gagaccagcc tgaccaacat ggagaaaccc cgtctctact aaaaatacaa aaatattagc
     3001 cgggcgtggt ggtgcatgcc tgtaatccca gctactaggg aggctgaggc aggagaattg
     3061 cttgaacctg ggagacggag gttgcggtga gctgcagagg cctcacctct aattgagaca
     3121 caattatata ttgttgatat atatatatat atatatacac acacacacac acactatgat
     3181 ggataaatgc atgagtttct gtgagagcat tggaaaggag tttgtcactc aataggtgaa
     3241 gccaggctaa gatttaagct gagccaggga ggacttgaag gaatcatgat gagagagaag
     3301 gtaagtggct ttgccagcaa tgaaacagct gacataatgg taaccagtca gaggagggca
     3361 taactatgaa actggacacc ttggttgtca ggttagaagg atggggtgta gggttggtaa
     3421 gaaaagaatt cagggaagag cagcgatcag attatgaaga atttgtcttg agaaattaca
     3481 gaggatttaa accagaatgt taggaatagt tattctagca agatgaatgt ggaaagtgtt
     3541 agtgtgcatg tgatgagtct tgaagctgga aactaggtaa caggttctta aatagttcat
     3601 gtgaaaatca tgacagacta aggcagtggc tgtggggctg tccgggagtt ctctacagaa
     3661 aacatctaaa acttgaatgt gcaagtgagt agctaacttc caagcttccc atttctgtat
     3721 aatttaagca tgaaaatgag aacactgaga tttgataggc atgtagaagt cagagtaagc
     3781 aagagggctt gagttcatcg atgaacttca gtaactatcc ttgacttagt attggtggaa
     3841 accatttgtg aatttacaga ctccaaaaac aaaaagataa tttagagtct caaagtaaga
     3901 tttggggaga tgtccattgg agacagaagt ggagagaggg agaagttcat ttgttgacat
     3961 atttatgtat ggtgcaccta ctgtgtgcca agccatgtta gagatacagt gggagcaaaa
     4021 ccagatgtgt tttctgccct ctgactccag tggttgcaga attagcccag gaactagaat
     4081 tggatggagt cacacaaacc aaggaagggg attgtttgag gggggcactc agtcacatgt
     4141 ggctgaggcc aaagagaatg aagatatatt ttaaaattct ggatttggca aaatttaggc
     4201 tagtctttac ttttcataaa cctctctcat gttagagcag caaagaaaaa ccagtttgcc
     4261 aagaggtcac gagattgggc agtgaggaat ggggagttta gtttaaaaga caacactaga
     4321 tacttttgga agtttaccta ttctgtggtt cccttttatt gactaaatgg tgcccttcat
     4381 tcatgaagca agtatctatt tagtgactac tatgtgtcaa aagctatcta ggcccagaaa
     4441 cttttaagtg gaaaacaaaa caaagaccct gccctgacag atttcaatca tgtatatact
     4501 gtatgtatgt ttgtggaagg tgacataata gacaattgca gatagtgata agtgtgtaag
     4561 acaaggatac cacgagcgta atagacagtg gggatggagg aacctttaga aggttggtta
     4621 agttgaatga taaggagcca ttcttttgtc tttacctgaa tgacttatca ttcagccctt
     4681 tttgagtttt gggttgcttg cagagtttaa ccttgcctgt aattgaaact taattttgta
     4741 atagcataac ttcatgtaag aaaagcaaag caatacatta cagaattatt ttactgaaga
     4801 acttgtttca gagaaagagg ctgtttcaca tttattagca catttggatt atatttaggt
     4861 gttttatttt tttttaaaca aaggagtttg gatcataata caagagaagc acagggcaaa
     4921 gacactgcat aacctcaaga actaagaatg gaaggactgg ccaggcctgg tggtgcacac
     4981 ctgtaatccc agctactcag gaggctgagg cgagagaatc gcttgagcct ggggggcaga
     5041 ggttgcagtg agctgagaga acggcgggcg gcagagcgag actccatctc aaaaaaaaaa
     5101 aaggataaag gaaggactta agcaaaatct tccttgtaag tagaaggatg ttttgacaag
     5161 aaaagttgca atggaaaaat ggttctcatg tacacgagta tgtagaataa gcatcgtgtg
     5221 tggattggat tcagatcaaa acattgcttt tatgtttgtg tctttatacg gtgggagtat
     5281 accctggtgc cccaggatga agacttgacc tgacccatgt atttttagat tactcacaga
     5341 taacaaaaag tattttcatc atgattagtt gcgaaaacag ttttatttca ataggtaaaa
     5401 cgtgcagtcc tatgtaatcg tcagaaggta atcttaatta tagcttgggt gtgctttaaa
     5461 ctgcaagctg gcagtggagg gcacgattcc tctgatttca gctttctcct tatacttttc
     5521 tggagctgtg agctgcaagt taactcagtg ggattaaagt gtagactgga ggtacaaaag
     5581 gtgaggagtg aggagatagg gtagttcttc cttggctggc tggcttcata atccctgggc
     5641 cccgcagata attaaatcga ctttttctgt ctcaggcatt tgtatgacct ctttggaggt
     5701 tccctgctgg gtagttatcc ttgtatctga tggacccatc tcaatttaaa atactctgcc
     5761 aggttcggag gttcatgctt gtcatcccag cactttggga ggctcagagg tgccattggc
     5821 ttgagcccaa gagtttgaga ccagcctggg caacctggtg aaacctcttc tccattaaaa
     5881 atacaaaaaa ttagccaggc atggtggtat gtgcctgtag tcccagctac tcagggagct
     5941 gaggtggaag gattgcttga gcctgggagg tcaaggctgc agtgaacctt gattgtgcca
     6001 ctgcactcca gcctggatga caaagaccct gtctcaagaa aagtctgtaa ttctttccta
     6061 acccttagta tccagcctca gtcctgaggt tttctttacc tctgggggct attttatgcc
     6121 ggctctctcc tgagtgtcac acatctggtc ctcaggaaac attctcacat ccctggcctg
     6181 aaaaaaacaa tttcagggag atcgcatggc agcagccctc tctgggctcc ccagctaaat
     6241 ggttgtacga aacacatttc aaagctctct gaagggcttc cttgaagttc ctttcactgg
     6301 gtttcaaagt agaaggtagt aactcctttg tccaagaagg ctgaattgag cacttaacaa
     6361 ttctccaaag aaatttcttc attggtctct atcctagacc ccttctgtat ccttgatatg
     6421 gctgaggatt ctaaaaaatg accagtctta catgggaggg ctgggatata aaaaataaaa
     6481 taataaataa tgataaaaac tgaaaactga ccacgttctt ggatatgttt tctttgggtt
     6541 gtgtgtgtgt gtgagacttt tgatagttac ccaaagtagg aaaaatccca ttctaataag
     6601 gttatattta tgtagctctg caaataaaca tctagcaaat gtaaaaagta ttttctttgc
     6661 cttaaaaatg attaaaatta tttgaactcc tgaggagtgt tatatgaata aaattagtaa
     6721 gttatttgga ggaaagttat tttttaaaaa gacaactggt aaaacagtac aggagaaagg
     6781 ccagcttcct caagtgagga cagttgttta gaattgactg aggagcggcc gggtgcggag
     6841 gctcacatct gtaatcccac acgccttggg aggctctgag gcgggtagat cacctgaggt
     6901 caggagtttg agaccagcct ggccaacatg gcgaaacccc gtctccacta aaaatacaaa
     6961 aattagccag gtgcagtggc acacacctgt aatcccagct actccgaagg ctgaggcagg
     7021 aggatcacct gagcccagga agttgagact gcagtgagct gagattgcac cactgcactc
     7081 cagcctcagt gacagcgaga ctgtctcaaa aaaagaaaaa agtgactgag gaggaagagg
     7141 ccaggtggca aatggaacag aatcaccaaa gggtgaacag gactaaggca atgtagtgta
     7201 tggctcagct acgtcagagt ggaaaaggtg ttattagagc agaaactatg gtccctgcgt
     7261 cacagggaag caacctacag agaagcagca gctccccaag agaggagaga taagaagcca
     7321 gaagcctcag agtgaacaat tgtcctatta gggattgctc tagagagaga aacctctggg
     7381 aacgtacccc tgtgaggcag cacagcacaa tgcttttaga attgtatgag agttgatata
     7441 tctccatttg ttttgcaaag gcaaaaacta agatacagag attatctgtt aaagttatgt
     7501 atttctttgg taataaagat gctgacagtg ttgctggaat gcatttcttt aataaagata
     7561 ttgtacaatg aaa
//
