LOCUS       NM_001001                676 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens ribosomal protein L36a like (RPL36AL), mRNA.
ACCESSION   NM_001001
VERSION     NM_001001.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 676)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 676)
  AUTHORS   Balasubramanian,S., Zheng,D., Liu,Y.J., Fang,G., Frankish,A.,
            Carriero,N., Robilotto,R., Cayting,P. and Gerstein,M.
  TITLE     Comparative analysis of processed ribosomal protein pseudogenes in
            four mammalian genomes
  JOURNAL   Genome Biol 10 (1), R2 (2009)
   PUBMED   19123937
REFERENCE   3  (bases 1 to 676)
  AUTHORS   Uechi,T., Maeda,N., Tanaka,T. and Kenmochi,N.
  TITLE     Functional second genes generated by retrotransposition of the
            X-linked ribosomal protein genes
  JOURNAL   Nucleic Acids Res 30 (24), 5369-5375 (2002)
   PUBMED   12490704
REFERENCE   4  (bases 1 to 676)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   5  (bases 1 to 676)
  AUTHORS   Feo,S., Davies,B. and Fried,M.
  TITLE     The mapping of seven intron-containing ribosomal protein genes
            shows they are unlinked in the human genome
  JOURNAL   Genomics 13 (1), 201-207 (1992)
   PUBMED   1577483
REFERENCE   6  (bases 1 to 676)
  AUTHORS   Gallagher,M.J., Chan,Y.L., Lin,A. and Wool,I.G.
  TITLE     Primary structure of rat ribosomal protein L36a
  JOURNAL   DNA 7 (4), 269-273 (1988)
   PUBMED   3396452
REFERENCE   7  (bases 1 to 676)
  AUTHORS   Davies,M.S., Henney,A., Ward,W.H. and Craig,R.K.
  TITLE     Characterisation of an mRNA encoding a human ribosomal protein
            homologous to the yeast L44 ribosomal protein
  JOURNAL   Gene 45 (2), 183-191 (1986)
   PUBMED   3542712
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY121971.1, BM973694.1 and
            AL139099.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001001.4.
            
            Summary: Cytoplasmic ribosomes, organelles that catalyze protein
            synthesis, consist of a small 40S subunit and a large 60S subunit.
            Together these subunits are composed of 4 RNA species and
            approximately 80 structurally distinct proteins. This gene encodes
            a ribosomal protein that is a component of the 60S subunit. The
            protein, which shares sequence similarity with yeast ribosomal
            protein L44, belongs to the L44E (L36AE) family of ribosomal
            proteins. This gene and the human gene officially named ribosomal
            protein L36a (RPL36A) encode nearly identical proteins; however,
            they are distinct genes. Although the name of this gene has been
            referred to as ribosomal protein L36a (RPL36A), its official name
            is ribosomal protein L36a-like (RPL36AL). As is typical for genes
            encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.535149.1, CD520830.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298289.7/ ENSP00000346012.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               HY121971.1         15-403
            390-518             BM973694.1         16-144              c
            519-676             AL139099.3         43946-44103
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..676
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
                     /note="ribosomal protein L36a like"
                     /db_xref="GeneID:6166"
                     /db_xref="HGNC:HGNC:10346"
                     /db_xref="MIM:180469"
     exon            1..65
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
                     /inference="alignment:Splign:2.1.0"
     exon            66..676
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..422
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
                     /note="60S ribosomal protein L36a-like; ribosomal protein
                     HL44; large ribosomal subunit protein eL42-like; ribosomal
                     protein L36a pseudogene 42"
                     /codon_start=1
                     /product="ribosomal protein eL42-like"
                     /protein_id="NP_000992.1"
                     /db_xref="CCDS:CCDS9689.1"
                     /db_xref="GeneID:6166"
                     /db_xref="HGNC:HGNC:10346"
                     /db_xref="MIM:180469"
                     /translation="MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGRRRYDRK
                     QSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQ
                     VIQF"
     regulatory      491..496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
                     /note="hexamer: AATAAA"
     regulatory      495..500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
                     /note="hexamer: AATACA"
     polyA_site      512
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
     polyA_site      518
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
                     /note="major polyA site"
     polyA_site      644
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
     regulatory      657..662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
                     /note="hexamer: AATGAA"
     polyA_site      676
                     /gene="RPL36AL"
                     /gene_synonym="RPL36A; RPL36AP42; RPL36A_18_1363"
ORIGIN      
        1 cctgttaggc gagagctgcg aaaggcgaga gctgcgaagg gccaggtgtc gggcgctgtt
       61 tctcgttttc atcatataga caaaacagcc ctgctgcaaa gatggtcaac gtacctaaaa
      121 cccgaagaac cttctgtaag aagtgtggca agcatcagcc tcacaaagtg acacagtata
      181 agaagggcaa ggattctttg tatgcccagg gaaggaggcg ctatgatcgg aagcagagtg
      241 gctatggtgg gcagacaaag ccaattttcc ggaagaaggc taagaccaca aagaagattg
      301 tgctaaggct ggaatgtgtt gagcctaact gcagatccaa gaggatgctg gccattaaga
      361 gatgcaagca ttttgaactg ggaggagata agaagagaaa gggccaagtg atccagttct
      421 aaactttggg atatttttct tcaattttga agagaaaatg gtgaagccat agaaaagtta
      481 cccgagggaa aataaataca gtgatattct tacgcaaact ttttgtggtt tttacttata
      541 aatagaattc catgtttagt gtagtcccac ctcaaacttt actaacaagt ttatatatgt
      601 atgaagggaa aatactactt tactactttt tgttttctgg tcaatttcaa atgttgaatg
      661 aattcataaa cattga
//
