LOCUS       NM_021029                761 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L36a (RPL36A), mRNA.
ACCESSION   NM_021029
VERSION     NM_021029.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 761)
  AUTHORS   He,Q., Xu,S., Ma,X., Ling,T., Feng,W., Lu,X., Liu,W. and Chen,Z.
  TITLE     Coupled folding-upon-binding of human tumor suppressor MIG6 to lung
            cancer EGFR kinase domain and molecular trimming/stapling of
            MIG6-derived beta-hairpins to target the coupling event
  JOURNAL   Eur Biophys J 52 (1-2), 17-25 (2023)
   PUBMED   36547692
  REMARK    GeneRIF: Coupled folding-upon-binding of human tumor suppressor
            MIG6 to lung cancer EGFR kinase domain and molecular
            trimming/stapling of MIG6-derived beta-hairpins to target the
            coupling event.
REFERENCE   2  (bases 1 to 761)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 761)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 761)
  AUTHORS   Xu,M., Wang,Y., He,H.T. and Yang,Q.
  TITLE     MiR-589-5p is a potential prognostic marker of hepatocellular
            carcinoma and regulates tumor cell growth by targeting MIG-6
  JOURNAL   Neoplasma 65 (5), 753-761 (2018)
   PUBMED   30249105
  REMARK    GeneRIF: miR-589-5p facilitated the growth of liver cancer cells by
            targeting MIG-6 and could be a prognosis biomarker for
            hepatocellular carcinoma
REFERENCE   5  (bases 1 to 761)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   6  (bases 1 to 761)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 761)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   8  (bases 1 to 761)
  AUTHORS   Oeltjen,J.C., Malley,T.M., Muzny,D.M., Miller,W., Gibbs,R.A. and
            Belmont,J.W.
  TITLE     Large-scale comparative sequence analysis of the human and murine
            Bruton's tyrosine kinase loci reveals conserved regulatory domains
  JOURNAL   Genome Res 7 (4), 315-329 (1997)
   PUBMED   9110171
REFERENCE   9  (bases 1 to 761)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 761)
  AUTHORS   Davies,M.S., Henney,A., Ward,W.H. and Craig,R.K.
  TITLE     Characterisation of an mRNA encoding a human ribosomal protein
            homologous to the yeast L44 ribosomal protein
  JOURNAL   Gene 45 (2), 183-191 (1986)
   PUBMED   3542712
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC062219.1, AW150895.1 and AL035422.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 22, 2018 this sequence version replaced NM_021029.5.
            
            Summary: Cytoplasmic ribosomes, organelles that catalyze protein
            synthesis, consist of a small 40S subunit and a large 60S subunit.
            Together these subunits are composed of 4 RNA species and
            approximately 80 structurally distinct proteins. This gene encodes
            a ribosomal protein that is a component of the 60S subunit. The
            protein, which shares sequence similarity with yeast ribosomal
            protein L44, belongs to the L44E (L36AE) family of ribosomal
            proteins. Although this gene has been referred to as ribosomal
            protein L44 (RPL44), its official name is ribosomal protein L36a
            (RPL36A). This gene and the human gene officially named ribosomal
            protein L36a-like (RPL36AL) encode nearly identical proteins;
            however, they are distinct genes. As is typical for genes encoding
            ribosomal proteins, there are multiple processed pseudogenes of
            this gene dispersed through the genome. Naturally occurring
            read-through transcription occurs between this locus and the
            heterogeneous nuclear ribonucleoprotein H2 (H') gene. [provided by
            RefSeq, Jan 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.42424.1,
                                           SRR1163658.249496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000553110.8/ ENSP00000446503.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               BC062219.1         33-430
            399-760             AW150895.1         1-362               c
            761-761             AL035422.12        77931-77931
FEATURES             Location/Qualifiers
     source          1..761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..761
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /note="ribosomal protein L36a"
                     /db_xref="GeneID:6173"
                     /db_xref="HGNC:HGNC:10359"
                     /db_xref="MIM:300902"
     exon            1..36
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..354
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /note="60S ribosomal protein L44; L44-like ribosomal
                     protein; dJ164F3.3 (ribosomal protein L44); cell
                     growth-inhibiting gene 15 protein; cell migration-inducing
                     gene 6 protein"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL42"
                     /protein_id="NP_066357.3"
                     /db_xref="CCDS:CCDS14483.3"
                     /db_xref="GeneID:6173"
                     /db_xref="HGNC:HGNC:10359"
                     /db_xref="MIM:300902"
                     /translation="MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRK
                     QSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQ
                     VIQF"
     exon            37..142
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /inference="alignment:Splign:2.1.0"
     exon            143..210
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /inference="alignment:Splign:2.1.0"
     exon            211..333
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /inference="alignment:Splign:2.1.0"
     exon            334..761
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      378..383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /note="hexamer: AATAAA"
     polyA_site      406
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /note="major polyA site"
     regulatory      452..457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /note="hexamer: AATACA"
     polyA_site      475
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
     polyA_site      531
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
     regulatory      735..740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
                     /note="hexamer: AATAAA"
     polyA_site      761
                     /gene="RPL36A"
                     /gene_synonym="eL42; L36A; L44L; MIG6; RPL44"
ORIGIN      
        1 ctttctttcc gcgccgatag cgctcacgca agcatggtta acgtccctaa aacccgccgg
       61 actttctgta agaagtgtgg caagcaccaa ccccataaag tgacacagta caagaagggc
      121 aaggattctc tgtacgccca gggaaagcgg cgttatgaca ggaagcagag tggctatggt
      181 gggcaaacta agccgatttt ccggaaaaag gctaaaacta caaagaagat tgtgctaagg
      241 cttgagtgcg ttgagcccaa ctgcagatct aagagaatgc tggctattaa aagatgcaag
      301 cattttgaac tgggaggaga taagaagaga aagggccaag tgatccagtt ctaagtgtca
      361 tcttttatta tgaagacaat aaaatcttga gtttatgttc acttcatttg tttgctgttc
      421 atcttttggg agggaataag ctagagccat caatacaatt ccgcttgtgg ggaaatttat
      481 gcctcttact ggtactactt gttttgcatt gaagctgact ggttgagttc acatcatatg
      541 ttgcaatttt ctaatttggc acttcaatca ctaggggcct tatgaggcag tttgtcatta
      601 tgcaatggtt attggttatc atgtgagtag acacatttca ggctaatagg gagaagtcag
      661 taacacattc atagtgaata tgagatgtct ttgctaagag ttaagtgtca gatctttgtt
      721 ataacagtta atttaataaa gaattttggc attgttcttc a
//
