LOCUS       NM_001199973            2531 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens RPL36A-HNRNPH2 readthrough (RPL36A-HNRNPH2),
            transcript variant 1, mRNA.
ACCESSION   NM_001199973
VERSION     NM_001199973.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2531)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS ONE 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2531)
  AUTHORS   Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R,
            Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T,
            Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K,
            Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T,
            Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T
            and Sugano S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res. 16 (1), 55-65 (2006)
   PUBMED   16344560
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035422.12 and DA998453.1.
            
            On Dec 25, 2018 this sequence version replaced NM_001199973.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring ribosomal protein L36a and
            heterogeneous nuclear ribonucleoprotein H2 (H') genes on chromosome
            X. The read-through transcript produces a protein with similarity
            to the protein encoded by the upstream locus, ribosomal protein
            L36a. Alternatively spliced transcript variants have been
            identified. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA998453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 3188, 6173
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL035422.12        72787-72787
            2-148               DA998453.1         2-148
            149-563             DA998453.1         150-564
            564-2531            AL035422.12        93942-95909
FEATURES             Location/Qualifiers
     source          1..2531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..2531
                     /gene="RPL36A-HNRNPH2"
                     /note="RPL36A-HNRNPH2 readthrough"
                     /db_xref="GeneID:100529097"
                     /db_xref="HGNC:HGNC:48349"
     exon            1..36
                     /gene="RPL36A-HNRNPH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..390
                     /gene="RPL36A-HNRNPH2"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="RPL36A-HNRNPH2 protein isoform a"
                     /protein_id="NP_001186902.2"
                     /db_xref="GeneID:100529097"
                     /db_xref="HGNC:HGNC:48349"
                     /translation="MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRK
                     QSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKLH
                     QNCIEPNLPPRAQQSP"
     exon            37..142
                     /gene="RPL36A-HNRNPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            143..210
                     /gene="RPL36A-HNRNPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            211..333
                     /gene="RPL36A-HNRNPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..2531
                     /gene="RPL36A-HNRNPH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36A-HNRNPH2"
                     /note="hexamer: AATAAA"
     polyA_site      2531
                     /gene="RPL36A-HNRNPH2"
                     /note="major polyA site"
ORIGIN      
        1 ctttctttcc gcgccgatag cgctcacgca agcatggtta acgtccctaa aacccgccgg
       61 actttctgta agaagtgtgg caagcaccaa ccccataaag tgacacagta caagaagggc
      121 aaggattctc tgtacgccca gggaaagcgg cgttatgaca ggaagcagag tggctatggt
      181 gggcaaacta agccgatttt ccggaaaaag gctaaaacta caaagaagat tgtgctaagg
      241 cttgagtgcg ttgagcccaa ctgcagatct aagagaatgc tggctattaa aagatgcaag
      301 cattttgaac tgggaggaga taagaagaga aagctacacc aaaattgcat tgagccaaac
      361 ttgccaccaa gagcccaaca atcaccatga tgctgagcac ggaaggcagg gaggggttcg
      421 tggtgaaggt caggggccta ccctggtcct gctcagccga tgaagtgatg cgcttcttct
      481 ctgattgcaa gatccaaaat ggcacatcag gtattcgttt catctacacc agagaaggca
      541 gaccaagtgg tgaagcattt gttgaacttg aatctgaaga ggaagtgaaa ttggctttga
      601 agaaggacag agaaaccatg ggacacagat acgttgaagt attcaagtct aacagtgttg
      661 aaatggattg ggtgttgaag catacaggtc cgaatagccc tgatactgcc aacgatggct
      721 tcgtccggct tagaggactc ccatttggct gtagcaagga agagattgtt cagttctttt
      781 cagggttgga aattgtgcca aatgggatga cactgccagt ggactttcag gggcgaagca
      841 caggggaagc ctttgtgcag tttgcttcac aggagatagc tgagaaggcc ttaaagaaac
      901 acaaggaaag aatagggcac aggtacattg agatcttcaa gagtagccga gctgaagttc
      961 gaacccacta tgatccccct cgaaagctca tggctatgca gcggccaggt ccctatgata
     1021 ggccgggggc tggcagaggg tataatagca ttggcagagg agctgggttt gaaaggatga
     1081 ggcgtggtgc ctatggtgga gggtatggag gctatgatga ctatggtggc tataatgatg
     1141 gatatggctt tgggtctgat agatttggaa gagacctcaa ttactgtttt tcaggaatgt
     1201 ctgatcatag atacggagat ggtgggtcca gtttccagag caccacaggg cactgtgtac
     1261 acatgagggg gttaccttac agagccactg agaatgatat ttataatttc ttctcacctc
     1321 ttaatcccat gagagtacat attgaaattg gacccgatgg cagagttacc ggtgaggcag
     1381 atgttgaatt tgctactcat gaagatgctg tggcagctat ggcaaaagac aaagctaata
     1441 tgcaacacag atatgtggag ctcttcttaa attctactgc aggaacaagt gggggtgctt
     1501 acgatcacag ctatgtagaa ctttttttga attctacagc aggggcaagt ggtggcgctt
     1561 atggtagcca aatgatggga gggatgggct tatccaacca gtctagttat ggaggtcctg
     1621 ctagccagca gctgagtggt ggttatggag gtggttatgg tggtcagagc agtatgagtg
     1681 gatatgacca agttctgcag gaaaactcca gtgactatca gtcaaacctt gcttaggtag
     1741 agaaggagca ctaaatagct actccagata taaaagctgt acatttgtgg gagttgaata
     1801 gaatgggagg gatgtttagt atatccagta tgattggtaa atgggaaata taattgattc
     1861 tgatcactct tggtcagctt ctctttcttt atctttcttt ctcctttttt aagaaaacga
     1921 gttaagttta acagttttgc attacaggct tgtgattcat gcttactgta aagtggaagt
     1981 tgagattatt ttaaaacttc aagctcagta attttgaaca ctgaaacatt catctaggac
     2041 ataataacaa agttcagtat tgaccataac tgttaaaaca atttttagct ttcctcaagt
     2101 tagttatgtt gtaggagtgt acctaagcag taagcgtatt taggttaatg cagtttcact
     2161 tatgttaaat gttgctctta taccacaaat acattgaaaa cttcggatgc atgttgagaa
     2221 acatgccttt ctgtaaaact caaatatagg agctgtgtct acgattcaaa gtgaaaacat
     2281 ttggcatgtt tgttaattct agctttttgg tttaatatcc tgtaaggcac gtgagtgtac
     2341 actttttttt tttttaagga tacgggacaa ttttaagatg taataccaat actttagaag
     2401 tttggtcgtg tcgtttgtat gaaaatctga ggctttggtt taaatctttc cttgtattgt
     2461 gatttccatt tagatgtatt gtactaagtg aaacttgtta aataaatctt ccttttaaaa
     2521 actggaaaaa a
//
