LOCUS       NM_033643                607 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L36 (RPL36), transcript variant 1,
            mRNA.
ACCESSION   NM_033643
VERSION     NM_033643.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Wang,J., Guo,X., Chen,Y., Zhang,W., Ren,J. and Gao,A.
  TITLE     The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell
            proliferation to mediate benzene hematotoxicity by recognizing m6A
            modification
  JOURNAL   Toxicology 503, 153758 (2024)
   PUBMED   38367942
  REMARK    GeneRIF: The m6A reader IGF2BP1 attenuates the stability of RPL36
            and cell proliferation to mediate benzene hematotoxicity by
            recognizing m6A modification.
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 607)
  AUTHORS   Cao,X., Khitun,A., Luo,Y., Na,Z., Phoodokmai,T., Sappakhaw,K.,
            Olatunji,E., Uttamapinant,C. and Slavoff,S.A.
  TITLE     Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by
            interacting with TMEM24
  JOURNAL   Nat Commun 12 (1), 508 (2021)
   PUBMED   33479206
  REMARK    GeneRIF: Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling
            pathway by interacting with TMEM24.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 607)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 607)
  AUTHORS   Odintsova,T.I., Muller,E.C., Ivanov,A.V., Egorov,T.A., Bienert,R.,
            Vladimirov,S.N., Kostka,S., Otto,A., Wittmann-Liebold,B. and
            Karpova,G.G.
  TITLE     Characterization and analysis of posttranslational modifications of
            the human large cytoplasmic ribosomal subunit proteins by mass
            spectrometry and Edman sequencing
  JOURNAL   J Protein Chem 22 (3), 249-258 (2003)
   PUBMED   12962325
REFERENCE   7  (bases 1 to 607)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   8  (bases 1 to 607)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   9  (bases 1 to 607)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 607)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BM841746.1, BC004971.1 and AC011499.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_033643.2.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L36E family of ribosomal proteins. It is located in the
            cytoplasm. Transcript variants derived from alternative splicing
            exist; they encode the same protein. As is typical for genes
            encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the predominant transcript
            and has a different 5' UTR than variant 2. Variants 1 and 2 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.484761.1,
                                           SRR1163655.141457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347512.8/ ENSP00000252543.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BM841746.1         35-45
            12-399              BC004971.1         1-388
            400-607             AC011499.5         65045-65252
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..607
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /note="ribosomal protein L36"
                     /db_xref="GeneID:25873"
                     /db_xref="HGNC:HGNC:13631"
                     /db_xref="MIM:617893"
     exon            1..33
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /inference="alignment:Splign:2.1.0"
     exon            34..128
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..353
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /note="60S ribosomal protein L36"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL36"
                     /protein_id="NP_378669.1"
                     /db_xref="CCDS:CCDS12147.1"
                     /db_xref="GeneID:25873"
                     /db_xref="HGNC:HGNC:13631"
                     /db_xref="MIM:617893"
                     /translation="MALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMI
                     REVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAA
                     KKD"
     exon            129..263
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /inference="alignment:Splign:2.1.0"
     exon            264..607
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      378..383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /note="hexamer: AATAAA"
     polyA_site      399
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /note="major polyA site"
     regulatory      586..591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
                     /note="hexamer: ATTAAA"
     polyA_site      607
                     /gene="RPL36"
                     /gene_synonym="eL36; L36"
ORIGIN      
        1 ccttccgcca cggccgtctc tggagagcag cagccatggc cctacgctac cctatggccg
       61 tgggcctcaa caagggccac aaagtgacca agaacgtgag caagcccagg cacagccgac
      121 gccgcgggcg tctgaccaaa cacaccaagt tcgtgcggga catgattcgg gaggtgtgtg
      181 gctttgcccc gtacgagcgg cgcgccatgg agttactgaa ggtctccaag gacaaacggg
      241 ccctcaaatt tatcaagaaa agggtgggga cgcacatccg cgccaagagg aagcgggagg
      301 agctgagcaa cgtactggcc gccatgagga aagctgctgc caagaaagac tgagcccctc
      361 ccctgccctc tccctgaaat aaagaacagc ttgacagaag ccctggctct cctgctgtcc
      421 gtgggtgggt gtgggtgtgt cgggggcccg cagtcccctg tctggtgccc gctctgagcc
      481 acaccctctc cgggtgctgc ctggtcgtga atcaaaagcc gtggcccgcc cacccttccc
      541 ggggcagcag gtgaggaagc cgccgtactg caaatgactt taatcattaa atagcttcta
      601 tgccaca
//
