LOCUS       NM_000996               1234 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens ribosomal protein L35a (RPL35A), transcript variant 2,
            mRNA.
ACCESSION   NM_000996
VERSION     NM_000996.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1234)
  AUTHORS   Wu,H., Xia,L., Sun,L., Li,D., Liu,X., Song,H., Sheng,J., Wang,K.
            and Feng,Q.
  TITLE     RPL35A drives ovarian cancer progression by promoting the binding
            of YY1 to CTCF promoter
  JOURNAL   J Cell Mol Med 28 (6), e18115 (2024)
   PUBMED   38436544
  REMARK    GeneRIF: RPL35A drives ovarian cancer progression by promoting the
            binding of YY1 to CTCF promoter.
REFERENCE   2  (bases 1 to 1234)
  AUTHORS   Zhang,C., Wang,Y., Wu,G., Sun,N., Bai,H., Li,X., Han,S., Zhou,H.,
            Qi,R. and Zhang,J.
  TITLE     RPL35A promotes the progression of cholangiocarcinoma by mediating
            HSPA8 ubiquitination
  JOURNAL   Biol Direct 19 (1), 16 (2024)
   PUBMED   38395908
  REMARK    GeneRIF: RPL35A promotes the progression of cholangiocarcinoma by
            mediating HSPA8 ubiquitination.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1234)
  AUTHORS   Gianferante,M.D., Wlodarski,M.W., Atsidaftos,E., Da Costa,L.,
            Delaporta,P., Farrar,J.E., Goldman,F.D., Hussain,M., Kattamis,A.,
            Leblanc,T., Lipton,J.M., Niemeyer,C.M., Pospisilova,D.,
            Quarello,P., Ramenghi,U., Sankaran,V.G., Vlachos,A.,
            Volejnikova,J., Alter,B.P., Savage,S.A. and Giri,N.
  TITLE     Genotype-phenotype association and variant characterization in
            Diamond-Blackfan anemia caused by pathogenic variants in RPL35A
  JOURNAL   Haematologica 106 (5), 1303-1310 (2021)
   PUBMED   32241839
  REMARK    GeneRIF: Genotype-phenotype association and variant
            characterization in Diamond-Blackfan anemia caused by pathogenic
            variants in RPL35A.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1234)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1234)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1234)
  AUTHORS   Colombo,P., Read,M. and Fried,M.
  TITLE     The human L35a ribosomal protein (RPL35A) gene is located at
            chromosome band 3q29-qter
  JOURNAL   Genomics 32 (1), 148-150 (1996)
   PUBMED   8786106
REFERENCE   7  (bases 1 to 1234)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 1234)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
REFERENCE   9  (bases 1 to 1234)
  AUTHORS   Feo,S., Davies,B. and Fried,M.
  TITLE     The mapping of seven intron-containing ribosomal protein genes
            shows they are unlinked in the human genome
  JOURNAL   Genomics 13 (1), 201-207 (1992)
   PUBMED   1577483
REFERENCE   10 (bases 1 to 1234)
  AUTHORS   Herzog,H., Hofferer,L., Schneider,R. and Schweiger,M.
  TITLE     cDNA encoding the human homologue of rat ribosomal protein L35a
  JOURNAL   Nucleic Acids Res 18 (15), 4600 (1990)
   PUBMED   2388839
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC010949.1, BM972808.1 and AW575227.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 8, 2018 this sequence version replaced NM_000996.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L35AE family of ribosomal proteins. It is located in the
            cytoplasm. The rat protein has been shown to bind to both initiator
            and elongator tRNAs, and thus, it is located at the P site, or P
            and A sites, of the ribosome. Although this gene was originally
            mapped to chromosome 18, it has been established that it is located
            at 3q29-qter. Alternative splicing results in multiple transcript
            variants. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.66844.1,
                                           SRR5189658.88288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000647248.2/ ENSP00000495672.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-470               BC010949.1         14-483
            471-900             BM972808.1         180-609             c
            901-1234            AW575227.1         17-350              c
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1234
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /note="ribosomal protein L35a"
                     /db_xref="GeneID:6165"
                     /db_xref="HGNC:HGNC:10345"
                     /db_xref="MIM:180468"
     exon            1..32
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /inference="alignment:Splign:2.1.0"
     exon            33..75
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..397
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /note="60S ribosomal protein L35a; cell growth-inhibiting
                     gene 33 protein"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL33"
                     /protein_id="NP_000987.2"
                     /db_xref="CCDS:CCDS33930.1"
                     /db_xref="GeneID:6165"
                     /db_xref="HGNC:HGNC:10345"
                     /db_xref="MIM:180468"
                     /translation="MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLG
                     KRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIR
                     VMLYPSRI"
     exon            76..228
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /inference="alignment:Splign:2.1.0"
     exon            229..373
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /inference="alignment:Splign:2.1.0"
     exon            374..1234
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      416..421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /note="hexamer: AATAAA"
     polyA_site      441
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
     regulatory      453..458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /note="hexamer: ATTAAA"
     polyA_site      475
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /note="major polyA site"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
                     /note="hexamer: AATAAA"
     polyA_site      1234
                     /gene="RPL35A"
                     /gene_synonym="DBA5; eL33; L35A"
ORIGIN      
        1 cttctcttac cgccatcttg gctcctgtgg aggcctgctg ggaacgggac ttctaaaagg
       61 aactatgtct ggaaggctgt ggtccaaggc catttttgct ggctataagc ggggtctccg
      121 gaaccaaagg gagcacacag ctcttcttaa aattgaaggt gtttacgccc gagatgaaac
      181 agaattctat ttgggcaaga gatgcgctta tgtatataaa gcaaagaaca acacagtcac
      241 tcctggcggc aaaccaaaca aaaccagagt catctgggga aaagtaactc gggcccatgg
      301 aaacagtggc atggttcgtg ccaaattccg aagcaatctt cctgctaagg ccattggaca
      361 cagaatccga gtgatgctgt acccctcaag gatttaaact aacgaaaaat caataaataa
      421 atgtggattt gtgctcttgt atttttaagt ggattaaaaa acttactacc ttaaattgat
      481 ttgctacatg cttaaaatga tagaggttgc tcagcatttt tggagtacaa gggggtcaga
      541 gagacatgtg atgaaaatta cagggcgagt acagagattt agaagggaac gggttttaat
      601 gcgagtatct ttgacagagt cttgctctgt tgcccatgct ggagtgtagt ggtgctcgct
      661 gcagcctcac attcaaaggc tcaagcaatc ctcccttggc ctttgaagta gctgggacca
      721 caggctcatg ccaccatccc tgggtcattt ttaaattttt tgtagagagg gtctgactct
      781 tgcctatgct ggcttcaaac tcctgggctc aagcaatcct ccttccttgg cctctcctga
      841 agtgctggga tacagttatg agccaccaca cctgccaagt gctttgtgat actatgcatt
      901 tgttcaatgc agattgggaa acttaaaatt tgaatggaga ttatgttgat gggctttggc
      961 agttcatttg gatagactgg gatgagaagc tcttgggact tgtgactgga caaagcattc
     1021 cagtatatta aaataaaatt aagccatatt actccactca taaaaagcaa tcctatggta
     1081 ggtacatgga ggttgggaat agtgcacgga aaggtggcag ctttctttgg cttcatgttt
     1141 taatctggta aagttcaaga ttgcacttta agcaggcctc ctaaatattt tagatttctt
     1201 ggggatatgc taaaataaaa caactaaggc atca
//
