LOCUS       NM_007209                452 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ribosomal protein L35 (RPL35), mRNA.
ACCESSION   NM_007209
VERSION     NM_007209.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Liu,P.Y., Tee,A.E., Milazzo,G., Hannan,K.M., Maag,J., Mondal,S.,
            Atmadibrata,B., Bartonicek,N., Peng,H., Ho,N., Mayoh,C.,
            Ciaccio,R., Sun,Y., Henderson,M.J., Gao,J., Everaert,C.,
            Hulme,A.J., Wong,M., Lan,Q., Cheung,B.B., Shi,L., Wang,J.Y.,
            Simon,T., Fischer,M., Zhang,X.D., Marshall,G.M., Norris,M.D.,
            Haber,M., Vandesompele,J., Li,J., Mestdagh,P., Hannan,R.D.,
            Dinger,M.E., Perini,G. and Liu,T.
  TITLE     The long noncoding RNA lncNB1 promotes tumorigenesis by interacting
            with ribosomal protein RPL35
  JOURNAL   Nat Commun 10 (1), 5026 (2019)
   PUBMED   31690716
  REMARK    GeneRIF: This study therefore identifies lncNB1 and its binding
            protein RPL35 as key factors for promoting E2F1 protein synthesis,
            N-Myc protein stability and N-Myc-driven oncogenesis, and as
            therapeutic targets.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 452)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   4  (bases 1 to 452)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   5  (bases 1 to 452)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 452)
  AUTHORS   Mazumder,B., Sampath,P., Seshadri,V., Maitra,R.K., DiCorleto,P.E.
            and Fox,P.L.
  TITLE     Regulated release of L13a from the 60S ribosomal subunit as a
            mechanism of transcript-specific translational control
  JOURNAL   Cell 115 (2), 187-198 (2003)
   PUBMED   14567916
REFERENCE   7  (bases 1 to 452)
  AUTHORS   Odintsova,T.I., Muller,E.C., Ivanov,A.V., Egorov,T.A., Bienert,R.,
            Vladimirov,S.N., Kostka,S., Otto,A., Wittmann-Liebold,B. and
            Karpova,G.G.
  TITLE     Characterization and analysis of posttranslational modifications of
            the human large cytoplasmic ribosomal subunit proteins by mass
            spectrometry and Edman sequencing
  JOURNAL   J Protein Chem 22 (3), 249-258 (2003)
   PUBMED   12962325
REFERENCE   8  (bases 1 to 452)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   9  (bases 1 to 452)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 452)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BM854016.1, U12465.1 and CR996819.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007209.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L29P family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV759294.1, BM740758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348462.6/ ENSP00000259469.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BM854016.1         5-52
            49-451              U12465.1           31-433
            452-452             CR996819.1         441-441
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..452
                     /gene="RPL35"
                     /gene_synonym="DBA19; L35; uL29"
                     /note="ribosomal protein L35"
                     /db_xref="GeneID:11224"
                     /db_xref="HGNC:HGNC:10344"
                     /db_xref="MIM:618315"
     exon            1..48
                     /gene="RPL35"
                     /gene_synonym="DBA19; L35; uL29"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..417
                     /gene="RPL35"
                     /gene_synonym="DBA19; L35; uL29"
                     /note="60S ribosomal protein L35"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL29"
                     /protein_id="NP_009140.1"
                     /db_xref="CCDS:CCDS6858.1"
                     /db_xref="GeneID:11224"
                     /db_xref="HGNC:HGNC:10344"
                     /db_xref="MIM:618315"
                     /translation="MAKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKL
                     SKIRVVRKSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEENL
                     KTKKQQRKERLYPLRKYAVKA"
     exon            49..185
                     /gene="RPL35"
                     /gene_synonym="DBA19; L35; uL29"
                     /inference="alignment:Splign:2.1.0"
     exon            186..267
                     /gene="RPL35"
                     /gene_synonym="DBA19; L35; uL29"
                     /inference="alignment:Splign:2.1.0"
     exon            268..452
                     /gene="RPL35"
                     /gene_synonym="DBA19; L35; uL29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      431..436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL35"
                     /gene_synonym="DBA19; L35; uL29"
                     /note="hexamer: AATAAA"
     polyA_site      452
                     /gene="RPL35"
                     /gene_synonym="DBA19; L35; uL29"
                     /note="major polyA site"
ORIGIN      
        1 ctctttccct cggagcgggc ggcggcgttg gcggcttgtg cagcaatggc caagatcaag
       61 gctcgagatc ttcgcgggaa gaagaaggag gagctgctga aacagctgga cgacctgaag
      121 gtggagctgt cccagctgcg cgtcgccaaa gtgacaggcg gtgcggcctc caagctctct
      181 aagatccgag tcgtccggaa atccattgcc cgtgttctca cagttattaa ccagactcag
      241 aaagaaaacc tcaggaaatt ctacaagggc aagaagtaca agcccctgga cctgcggcct
      301 aagaagacac gtgccatgcg ccgccggctc aacaagcacg aggagaacct gaagaccaag
      361 aagcagcagc ggaaggagcg gctgtacccg ctgcggaagt acgcggtcaa ggcctgaggg
      421 gcgcattgtc aataaagcac agctggctga ga
//
