LOCUS       NM_001319236             546 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L34 (RPL34), transcript variant 6,
            mRNA.
ACCESSION   NM_001319236 XM_005263172
VERSION     NM_001319236.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 546)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 546)
  AUTHORS   Zhu,Y., Ren,C., Jiang,D., Yang,L., Chen,Y., Li,F., Wang,B. and
            Zhang,Y.
  TITLE     RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis
            via the MDM2-P53 pathway
  JOURNAL   Cancer Sci 112 (5), 1811-1821 (2021)
   PUBMED   33675124
  REMARK    GeneRIF: RPL34-AS1-induced RPL34 inhibits cervical cancer cell
            tumorigenesis via the MDM2-P53 pathway.
REFERENCE   3  (bases 1 to 546)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 546)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 546)
  AUTHORS   Ji,P., Wang,L., Liu,J., Mao,P., Li,R., Jiang,H., Lou,M., Xu,M. and
            Yu,X.
  TITLE     Knockdown of RPL34 inhibits the proliferation and migration of
            glioma cells through the inactivation of JAK/STAT3 signaling
            pathway
  JOURNAL   J Cell Biochem 120 (3), 3259-3267 (2019)
   PUBMED   30216512
  REMARK    GeneRIF: Findings indicated that knockdown of RPL34 inhibits the
            proliferation and migration of glioma cells through the
            inactivation of JAK/STAT3 signaling pathway.
REFERENCE   6  (bases 1 to 546)
  AUTHORS   Yang,S., Cui,J., Yang,Y., Liu,Z., Yan,H., Tang,C., Wang,H., Qin,H.,
            Li,X., Li,J., Wang,W., Huang,Y. and Gao,H.
  TITLE     Over-expressed RPL34 promotes malignant proliferation of non-small
            cell lung cancer cells
  JOURNAL   Gene 576 (1 Pt 3), 421-428 (2016)
   PUBMED   26526135
  REMARK    GeneRIF: over-expressed RPL34 may promote malignant proliferation
            of NSCLC cells, thus playing an important role in development and
            progress of NSCLC
REFERENCE   7  (bases 1 to 546)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   8  (bases 1 to 546)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   9  (bases 1 to 546)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 546)
  AUTHORS   Rommens,J.M., Durocher,F., McArthur,J., Tonin,P., LeBlanc,J.F.,
            Allen,T., Samson,C., Ferri,L., Narod,S., Morgan,K. et al.
  TITLE     Generation of a transcription map at the HSD17B locus centromeric
            to BRCA1 at 17q21
  JOURNAL   Genomics 28 (3), 530-542 (1995)
   PUBMED   7490091
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC106009.1 and DA779124.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001319236.1.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L34E family of ribosomal proteins. It is located in the
            cytoplasm. This gene originally was thought to be located at 17q21,
            but it has been mapped to 4q. Overexpression of this gene has been
            observed in some cancer cells. Alternative splicing results in
            multiple transcript variants, all encoding the same isoform. As is
            typical for genes encoding ribosomal proteins, there are multiple
            processed pseudogenes of this gene dispersed through the genome.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (6) differs in its 5' and 3' UTRs
            compared to variant 2. Variants 1-6 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA779124.1, DA087207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394667.8/ ENSP00000378162.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               BC106009.1         11-442
            433-546             DA779124.1         432-545
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..546
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /note="ribosomal protein L34"
                     /db_xref="GeneID:6164"
                     /db_xref="HGNC:HGNC:10340"
                     /db_xref="MIM:616862"
     exon            1..25
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /inference="alignment:Splign:2.1.0"
     exon            26..99
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..388
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /note="60S ribosomal protein L34; leukemia-associated
                     protein"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL34"
                     /protein_id="NP_001306165.1"
                     /db_xref="CCDS:CCDS3680.1"
                     /db_xref="GeneID:6164"
                     /db_xref="HGNC:HGNC:10340"
                     /db_xref="MIM:616862"
                     /translation="MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKS
                     ACGVCPGRLRGVRAVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRDRIKRAFLIEEQKI
                     VVKVLKAQAQSQKAK"
     exon            100..199
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /inference="alignment:Splign:2.1.0"
     exon            200..303
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /inference="alignment:Splign:2.1.0"
     exon            304..546
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      410..415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /note="hexamer: AATAAA"
     polyA_site      432
                     /gene="RPL34"
                     /gene_synonym="eL34; L34"
                     /note="major polyA site"
ORIGIN      
        1 cctcttccgg ggacgttgtc tgcaggcact cagaatggtc cagcgtttga cataccgacg
       61 taggctttcc tacaatacag cctctaacaa aactaggctg tcccgaaccc ctggtaatag
      121 aattgtttac ctttatacca agaaggttgg gaaagcacca aaatctgcat gtggtgtgtg
      181 cccaggcaga cttcgagggg ttcgtgctgt aagacctaaa gttcttatga gattgtccaa
      241 aacaaagaaa catgtcagca gggcctatgg tggttccatg tgtgctaaat gtgttcgtga
      301 caggatcaag cgtgctttcc ttatcgagga gcagaaaatc gttgtgaaag tgttgaaggc
      361 acaagcacag agtcagaaag ctaaataaaa aaatgaaact tttttgagta ataaaaatga
      421 aaagacgctg tatgtatgac tttttttttt tctgttgtaa tgtgttagta tacagatttt
      481 gtttctgtat ggtatttggg gaccctatag tttttagcag attacttttt cttgttttgt
      541 ttgttg
//
