LOCUS       NM_000993               1291 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens ribosomal protein L31 (RPL31), transcript variant 1,
            mRNA.
ACCESSION   NM_000993 NM_001098578
VERSION     NM_000993.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1291)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 1291)
  AUTHORS   Sharen,G., Li,X., Sun,J., Zhang,L., Xi,W., Zhao,X., Han,F., Jia,L.,
            A,R., Cheng,H. and Hou,M.
  TITLE     Silencing eL31 suppresses the progression of colorectal cancer via
            targeting DEPDC1
  JOURNAL   J Transl Med 20 (1), 493 (2022)
   PUBMED   36309731
  REMARK    GeneRIF: Silencing eL31 suppresses the progression of colorectal
            cancer via targeting DEPDC1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1291)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1291)
  AUTHORS   Nabeel-Shah,S., Lee,H., Ahmed,N., Burke,G.L., Farhangmehr,S.,
            Ashraf,K., Pu,S., Braunschweig,U., Zhong,G., Wei,H., Tang,H.,
            Yang,J., Marcon,E., Blencowe,B.J., Zhang,Z. and Greenblatt,J.F.
  TITLE     SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates
            stress granules to impair host stress response
  JOURNAL   iScience 25 (1), 103562 (2022)
   PUBMED   34901782
REFERENCE   5  (bases 1 to 1291)
  AUTHORS   Chen,Z., Wang,C., Feng,X., Nie,L., Tang,M., Zhang,H., Xiong,Y.,
            Swisher,S.K., Srivastava,M. and Chen,J.
  TITLE     Interactomes of SARS-CoV-2 and human coronaviruses reveal host
            factors potentially affecting pathogenesis
  JOURNAL   EMBO J 40 (17), e107776 (2021)
   PUBMED   34232536
REFERENCE   6  (bases 1 to 1291)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 1291)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 1291)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
REFERENCE   9  (bases 1 to 1291)
  AUTHORS   Chester,K.A., Robson,L., Begent,R.H., Talbot,I.C., Pringle,J.H.,
            Primrose,L., Macpherson,A.J., Boxer,G., Southall,P. and
            Malcolm,A.D.
  TITLE     Identification of a human ribosomal protein mRNA with increased
            expression in colorectal tumours
  JOURNAL   Biochim Biophys Acta 1009 (3), 297-300 (1989)
   PUBMED   2597680
REFERENCE   10 (bases 1 to 1291)
  AUTHORS   Nobori,T., Hexdall,L.E. and Carson,D.A.
  TITLE     cDNA sequence of human ribosomal protein L31
  JOURNAL   Nucleic Acids Res 17 (17), 7105 (1989)
   PUBMED   2780320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from DA869102.1, BC070373.1, BC017343.2 and AC016738.6.
            
            On Nov 23, 2018 this sequence version replaced NM_000993.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L31E family of ribosomal proteins. It is located in the
            cytoplasm. Higher levels of expression of this gene in familial
            adenomatous polyps compared to matched normal tissues have been
            observed. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. Alternatively spliced transcript variants
            encoding distinct isoforms have been found for this gene. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB106299.1, SRR1660809.181058.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264258.8/ ENSP00000264258.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DA869102.1         61-64
            5-442               BC070373.1         1-438
            443-447             BC017343.2         418-422
            448-1291            AC016738.6         98697-99540
FEATURES             Location/Qualifiers
     source          1..1291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1291
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /note="ribosomal protein L31"
                     /db_xref="GeneID:6160"
                     /db_xref="HGNC:HGNC:10334"
                     /db_xref="MIM:617415"
     exon            1..27
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..405
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /note="isoform 1 is encoded by transcript variant 1; 60S
                     ribosomal protein L31; large ribosomal subunit protein
                     eL31"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL31 isoform 1"
                     /protein_id="NP_000984.1"
                     /db_xref="CCDS:CCDS2049.1"
                     /db_xref="GeneID:6160"
                     /db_xref="HGNC:HGNC:10334"
                     /db_xref="MIM:617415"
                     /translation="MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPR
                     ALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKL
                     YTLVTYVPVTTFKNLQTVNVDEN"
     exon            28..134
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /inference="alignment:Splign:2.1.0"
     exon            135..260
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /inference="alignment:Splign:2.1.0"
     exon            261..373
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /inference="alignment:Splign:2.1.0"
     exon            374..1291
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      424..429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /note="hexamer: AATAAA"
     polyA_site      442
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /note="major polyA site"
     regulatory      798..803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /note="hexamer: AATGAA"
     polyA_site      845
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /note="hexamer: AGTAAA"
     polyA_site      993
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
     regulatory      1271..1276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
                     /note="hexamer: ATTAAA"
     polyA_site      1291
                     /gene="RPL31"
                     /gene_synonym="eL31; L31"
ORIGIN      
        1 cttcctttcc aacttggacg ctgcagaatg gctcccgcaa agaagggtgg cgagaagaaa
       61 aagggccgtt ctgccatcaa cgaagtggta acccgagaat acaccatcaa cattcacaag
      121 cgcatccatg gagtgggctt caagaagcgt gcacctcggg cactcaaaga gattcggaaa
      181 tttgccatga aggagatggg aactccagat gtgcgcattg acaccaggct caacaaagct
      241 gtctgggcca aaggaataag gaatgtgcca taccgaatcc gtgtgcggct gtccagaaaa
      301 cgtaatgagg atgaagattc accaaataag ctatatactt tggttaccta tgtacctgtt
      361 accactttca aaaatctaca gacagtcaat gtggatgaga actaatcgct gatcgtcaga
      421 tcaaataaag ttataaaatt gccttcatgt ttttgttctt tttagttgca acataatgta
      481 cttgtatacc ctatcctaat tatgggatca tttgaagagc ttttcccaaa ttgatggcct
      541 gtgctgcctt ctccccatcc cctggggttt taaagtgatt tcaaactgca acctagtttt
      601 agaaccactg ttctgggtag ttgggatact gaaggcatat tgttaattat tctacttgta
      661 tgttttgcta attctaagat aagcattttt ccagaaacca ggatgtagaa tccagttgcc
      721 attgacatct taacatttta ggaaacaact ttaaaatgat atactatcta tctatctatc
      781 tgtagcatct taaaggtaat gaaattaatg tggcagtagg tcttttaagc ttctgcctac
      841 atccatattg agtatagttg ttgtcttcta aaataattaa ttgatttttg gtgagataac
      901 cagattcata ttttaagcct tttgtaatgg ccccgtggta cctggagtca aggttcagaa
      961 gtaaaaagtt ccttaaggta tcaataacaa aaatttgtat taatagttca gtcctaaagc
     1021 agtgttgctg agattatgtt tcaccagcat ttacaagctg tatgttaaat gctgccataa
     1081 agaggtctct gaagccgtag ggcacaccca aggcagggct gagaagtacc tagtagtgtt
     1141 gcaccaccca aaaaccatgg atgggcagca gcaacatctc cagcttaccc attcactgcc
     1201 acagtctaca gcttaagaca cttaactaca aggtaaaaga aaaggaccaa gtaaatacaa
     1261 aaagtttctt attaaaaaac ttggaagcca a
//
