LOCUS       NM_000989                498 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ribosomal protein L30 (RPL30), mRNA.
ACCESSION   NM_000989
VERSION     NM_000989.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 498)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   4  (bases 1 to 498)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   5  (bases 1 to 498)
  AUTHORS   Martin,I., Kim,J.W., Lee,B.D., Kang,H.C., Xu,J.C., Jia,H.,
            Stankowski,J., Kim,M.S., Zhong,J., Kumar,M., Andrabi,S.A.,
            Xiong,Y., Dickson,D.W., Wszolek,Z.K., Pandey,A., Dawson,T.M. and
            Dawson,V.L.
  TITLE     Ribosomal protein s15 phosphorylation mediates LRRK2
            neurodegeneration in Parkinson's disease
  JOURNAL   Cell 157 (2), 472-485 (2014)
   PUBMED   24725412
REFERENCE   6  (bases 1 to 498)
  AUTHORS   Odintsova,T.I., Muller,E.C., Ivanov,A.V., Egorov,T.A., Bienert,R.,
            Vladimirov,S.N., Kostka,S., Otto,A., Wittmann-Liebold,B. and
            Karpova,G.G.
  TITLE     Characterization and analysis of posttranslational modifications of
            the human large cytoplasmic ribosomal subunit proteins by mass
            spectrometry and Edman sequencing
  JOURNAL   J Protein Chem 22 (3), 249-258 (2003)
   PUBMED   12962325
REFERENCE   7  (bases 1 to 498)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   8  (bases 1 to 498)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   9  (bases 1 to 498)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 498)
  AUTHORS   Feo,S., Davies,B. and Fried,M.
  TITLE     The mapping of seven intron-containing ribosomal protein genes
            shows they are unlinked in the human genome
  JOURNAL   Genomics 13 (1), 201-207 (1992)
   PUBMED   1577483
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BM785413.1 and BC095426.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000989.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L30E family of ribosomal proteins. It is located in the
            cytoplasm. This gene is co-transcribed with the U72 small nucleolar
            RNA gene, which is located in its fourth intron. As is typical for
            genes encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV761808.1, BE439872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287038.8/ ENSP00000287038.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BM785413.1         46-51
            7-498               BC095426.1         1-492
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..498
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /note="ribosomal protein L30"
                     /db_xref="GeneID:6156"
                     /db_xref="HGNC:HGNC:10333"
                     /db_xref="MIM:180467"
     exon            1..38
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /inference="alignment:Splign:2.1.0"
     exon            39..91
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..418
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /note="60S ribosomal protein L30"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL30"
                     /protein_id="NP_000980.1"
                     /db_xref="CCDS:CCDS34928.1"
                     /db_xref="GeneID:6156"
                     /db_xref="HGNC:HGNC:10333"
                     /db_xref="MIM:180467"
                     /translation="MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAK
                     LVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDS
                     DIIRSMPEQTGEK"
     exon            92..237
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /inference="alignment:Splign:2.1.0"
     exon            238..368
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /inference="alignment:Splign:2.1.0"
     exon            369..498
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      475..480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /note="hexamer: AATAAA"
     polyA_site      498
                     /gene="RPL30"
                     /gene_synonym="eL30; L30"
                     /note="major polyA site"
ORIGIN      
        1 cctttctcgt tccccggcca tcttagcggc tgctgttggt tgggggccgt cccgctccta
       61 aggcaggaag atggtggccg caaagaagac gaaaaagtcg ctggagtcga tcaactctag
      121 gctccaactc gttatgaaaa gtgggaagta cgtcctgggg tacaagcaga ctctgaagat
      181 gatcagacaa ggcaaagcga aattggtcat tctcgctaac aactgcccag ctttgaggaa
      241 atctgaaata gagtactatg ctatgttggc taaaactggt gtccatcact acagtggcaa
      301 taatattgaa ctgggcacag catgcggaaa atactacaga gtgtgcacac tggctatcat
      361 tgatccaggt gactctgaca tcattagaag catgccagaa cagactggtg aaaagtaaac
      421 cttttcacct acaaaatttc acctgcaaac cttaaacctg caaaattttc ctttaataaa
      481 atttgcttgt tttaaaaa
//
