LOCUS       NM_000967               1296 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ribosomal protein L3 (RPL3), transcript variant 1,
            mRNA.
ACCESSION   NM_000967
VERSION     NM_000967.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Deng,N., Zhang,X. and Zhang,Y.
  TITLE     BAIAP2L1 accelerates breast cancer progression and chemoresistance
            by activating AKT signaling through binding with ribosomal protein
            L3
  JOURNAL   Cancer Sci 114 (3), 764-780 (2023)
   PUBMED   36308067
  REMARK    GeneRIF: BAIAP2L1 accelerates breast cancer progression and
            chemoresistance by activating AKT signaling through binding with
            ribosomal protein L3.
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Du,C., Wang,T., Jia,J., Li,J., Xiao,Y., Wang,J., Mao,P., Wang,N.,
            Shi,L. and Wang,M.
  TITLE     Suppression of RPL34 Inhibits Tumor Cell Proliferation and Promotes
            Apoptosis in Glioblastoma
  JOURNAL   Appl Biochem Biotechnol 194 (8), 3494-3506 (2022)
   PUBMED   35377127
  REMARK    GeneRIF: Suppression of RPL34 Inhibits Tumor Cell Proliferation and
            Promotes Apoptosis in Glioblastoma.
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Matsuura-Suzuki,E., Shimazu,T., Takahashi,M., Kotoshiba,K.,
            Suzuki,T., Kashiwagi,K., Sohtome,Y., Akakabe,M., Sodeoka,M.,
            Dohmae,N., Ito,T., Shinkai,Y. and Iwasaki,S.
  TITLE     METTL18-mediated histidine methylation of RPL3 modulates
            translation elongation for proteostasis maintenance
  JOURNAL   Elife 11, e72780 (2022)
   PUBMED   35674491
  REMARK    GeneRIF: METTL18-mediated histidine methylation of RPL3 modulates
            translation elongation for proteostasis maintenance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Malecki,J.M., Odonohue,M.F., Kim,Y., Jakobsson,M.E., Gessa,L.,
            Pinto,R., Wu,J., Davydova,E., Moen,A., Olsen,J.V., Thiede,B.,
            Gleizes,P.E., Leidel,S.A. and Falnes,P.O.
  TITLE     Human METTL18 is a histidine-specific methyltransferase that
            targets RPL3 and affects ribosome biogenesis and function
  JOURNAL   Nucleic Acids Res 49 (6), 3185-3203 (2021)
   PUBMED   33693809
  REMARK    GeneRIF: Human METTL18 is a histidine-specific methyltransferase
            that targets RPL3 and affects ribosome biogenesis and function.
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Mosca,L., Pagano,M., Pecoraro,A., Borzacchiello,L., Mele,L.,
            Cacciapuoti,G., Porcelli,M., Russo,G. and Russo,A.
  TITLE     S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in
            p53 Deleted Colon Cancer Cells
  JOURNAL   Int J Mol Sci 22 (1), 103 (2020)
   PUBMED   33374288
  REMARK    GeneRIF: S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug
            Resistance in p53 Deleted Colon Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 1296)
  AUTHORS   Van Raay,T.J., Connors,T.D., Klinger,K.W., Landes,G.M. and
            Burn,T.C.
  TITLE     A novel ribosomal protein L3-like gene (RPL3L) maps to the
            autosomal dominant polycystic kidney disease gene region
  JOURNAL   Genomics 37 (2), 172-176 (1996)
   PUBMED   8921388
REFERENCE   8  (bases 1 to 1296)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 1296)
  AUTHORS   Reddy,T.R., Suhasini,M., Rappaport,J., Looney,D.J., Kraus,G. and
            Wong-Staal,F.
  TITLE     Molecular cloning and characterization of a TAR-binding nuclear
            factor from T cells
  JOURNAL   AIDS Res Hum Retroviruses 11 (6), 663-669 (1995)
   PUBMED   7576925
REFERENCE   10 (bases 1 to 1296)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AK130450.1, BC012146.1 and BC071666.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000967.3.
            
            Summary: Ribosomes, the complexes that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L3P family of ribosomal proteins and it is located in the
            cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has
            been suggested that the protein contributes to tat-mediated
            transactivation. This gene is co-transcribed with several small
            nucleolar RNA genes, which are located in several of this gene's
            introns. Alternate transcriptional splice variants, encoding
            different isoforms, have been characterized. As is typical for
            genes encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.788490.1,
                                           SRR5189652.122410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216146.9/ ENSP00000346001.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK130450.1         938-950
            14-1294             BC012146.1         1-1281
            1295-1296           BC071666.1         1294-1295
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1296
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /note="ribosomal protein L3"
                     /db_xref="GeneID:6122"
                     /db_xref="HGNC:HGNC:10332"
                     /db_xref="MIM:604163"
     exon            1..29
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1238
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /EC_number="3.6.5.3"
                     /note="isoform a is encoded by transcript variant 1; 60S
                     ribosomal protein L3; HIV-1 TAR RNA-binding protein B;
                     large ribosomal subunit protein uL3"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL3 isoform a"
                     /protein_id="NP_000958.1"
                     /db_xref="CCDS:CCDS13988.1"
                     /db_xref="GeneID:6122"
                     /db_xref="HGNC:HGNC:10332"
                     /db_xref="MIM:604163"
                     /translation="MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLT
                     AFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTF
                     KTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVI
                     RVIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMID
                     VIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHH
                     RTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLK
                     GCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPL
                     KKDRIAKEEGA"
     exon            30..222
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     exon            223..391
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     exon            392..527
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     exon            528..714
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..875
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     exon            876..977
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1073
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1193
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1296
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /note="hexamer: AATAAA"
     polyA_site      1296
                     /gene="RPL3"
                     /gene_synonym="ASC-1; L3; TARBP-B; uL3"
                     /note="major polyA site"
ORIGIN      
        1 ctctaccggc gggatttgat ggcgtgatgt ctcacagaaa gttctccgct cccagacatg
       61 ggtccctcgg cttcctgcct cggaagcgca gcagcaggca tcgtgggaag gtgaagagct
      121 tccctaagga tgacccgtcc aagccggtcc acctcacagc cttcctggga tacaaggctg
      181 gcatgactca catcgtgcgg gaagtcgaca ggccgggatc caaggtgaac aagaaggagg
      241 tggtggaggc tgtgaccatt gtagagacac cacccatggt ggttgtgggc attgtgggct
      301 acgtggaaac ccctcgaggc ctccggacct tcaagactgt ctttgctgag cacatcagtg
      361 atgaatgcaa gaggcgtttc tataagaatt ggcataaatc taagaagaag gcctttacca
      421 agtactgcaa gaaatggcag gatgaggatg gcaagaagca gctggagaag gacttcagca
      481 gcatgaagaa gtactgccaa gtcatccgtg tcattgccca cacccagatg cgcctgcttc
      541 ctctgcgcca gaagaaggcc cacctgatgg agatccaggt gaacggaggc actgtggccg
      601 agaagctgga ctgggcccgc gagaggcttg agcagcaggt acctgtgaac caagtgtttg
      661 ggcaggatga gatgatcgac gtcatcgggg tgaccaaggg caaaggctac aaaggggtca
      721 ccagtcgttg gcacaccaag aagctgcccc gcaagaccca ccgaggcctg cgcaaggtgg
      781 cctgtattgg ggcatggcat cctgctcgtg tagccttctc tgtggcacgc gctgggcaga
      841 aaggctacca tcaccgcact gagatcaaca agaagattta taagattggc cagggctacc
      901 ttatcaagga cggcaagctg atcaagaaca atgcctccac tgactatgac ctatctgaca
      961 agagcatcaa ccctctgggt ggctttgtcc actatggtga agtgaccaat gactttgtca
     1021 tgctgaaagg ctgtgtggtg ggaaccaaga agcgggtgct caccctccgc aagtccttgc
     1081 tggtgcagac gaagcggcgg gctctggaga agattgacct taagttcatt gacaccacct
     1141 ccaagtttgg ccatggccgc ttccagacca tggaggagaa gaaagcattc atgggaccac
     1201 tgaagaaaga ccgaattgca aaggaagaag gagcttaatg ccaggaacag attttgcagt
     1261 tggtggggtc tcaataaaag ttattttcca ctgaca
//
