LOCUS       NM_000992                754 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L29 (RPL29), mRNA.
ACCESSION   NM_000992
VERSION     NM_000992.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 754)
  AUTHORS   Babaylova,E.S., Kolobova,A.V., Gopanenko,A.V., Tupikin,A.E.,
            Kabilov,M.R., Malygin,A.A. and Karpova,G.G.
  TITLE     The human ribosomal protein eL29 binds in vivo to the cognate mRNA
            by interacting with its coding sequence, as revealed from in-cell
            cross-linking data
  JOURNAL   Biochimie 177, 68-77 (2020)
   PUBMED   32798643
  REMARK    GeneRIF: The human ribosomal protein eL29 binds in vivo to the
            cognate mRNA by interacting with its coding sequence, as revealed
            from in-cell cross-linking data.
REFERENCE   2  (bases 1 to 754)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 754)
  AUTHORS   Li,J. and Peng,Y.
  TITLE     Knockdown RPL29 Gene Can Inhibit the Proliferation, Invasion of
            Squamous Cell Carcinomas
  JOURNAL   Ann Clin Lab Sci 49 (6), 763-769 (2019)
   PUBMED   31882427
  REMARK    GeneRIF: RPL29 is upregulated in the gingival squamous cell
            carcinoma.RPL29 role in the cell proliferation of the gingival
            squamous cell carcinoma.
REFERENCE   4  (bases 1 to 754)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   5  (bases 1 to 754)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 754)
  AUTHORS   Rohde,L.H., Julian,J., Babaknia,A. and Carson,D.D.
  TITLE     Cell surface expression of HIP, a novel heparin/heparan sulfate
            binding protein, of human uterine epithelial cells and cell lines
  JOURNAL   J Biol Chem 271 (20), 11824-11830 (1996)
   PUBMED   8662617
REFERENCE   7  (bases 1 to 754)
  AUTHORS   Liu,S., Smith,S.E., Julian,J., Rohde,L.H., Karin,N.J. and
            Carson,D.D.
  TITLE     cDNA cloning and expression of HIP, a novel cell surface heparan
            sulfate/heparin-binding protein of human uterine epithelial cells
            and cell lines
  JOURNAL   J Biol Chem 271 (20), 11817-11823 (1996)
   PUBMED   8662616
REFERENCE   8  (bases 1 to 754)
  AUTHORS   Law,P.T., Tsui,S.K., Lam,W.Y., Luk,S.C., Hwang,D.M., Liew,C.C.,
            Lee,C.Y., Fung,K.P. and Waye,M.M.
  TITLE     A novel cDNA encoding a human homologue of ribosomal protein L29
  JOURNAL   Biochim Biophys Acta 1305 (3), 105-108 (1996)
   PUBMED   8597591
REFERENCE   9  (bases 1 to 754)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (bases 1 to 754)
  AUTHORS   Nika,H. and Hultin,T.
  TITLE     Location of the sulfhydryl groups involved in disulfide interaction
            between the neighboring proteins L6 and L29 in mammalian ribosomes.
            S-cleavage of the cyanylated proteins in polyacrylamide gels after
            separation by dodecylsulfate gel electrophoresis
  JOURNAL   Eur J Biochem 142 (3), 521-526 (1984)
   PUBMED   6468376
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC008926.2 and AC115284.4.
            
            On May 17, 2019 this sequence version replaced NM_000992.2.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a cytoplasmic
            ribosomal protein that is a component of the 60S subunit. The
            protein belongs to the L29E family of ribosomal proteins. The
            protein is also a peripheral membrane protein expressed on the cell
            surface that directly binds heparin. Although this gene was
            previously reported to map to 3q29-qter, it is believed that it is
            located at 3p21.3-p21.2. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD249111.1, CD247488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294189.11/ ENSP00000294189.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-648               BC008926.2         48-695
            649-754             AC115284.4         75409-75514         c
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..754
                     /gene="RPL29"
                     /gene_synonym="eL29; HIP; HUMRPL29; L29; RPL29P10;
                     RPL29_3_370"
                     /note="ribosomal protein L29"
                     /db_xref="GeneID:6159"
                     /db_xref="HGNC:HGNC:10331"
                     /db_xref="MIM:601832"
     exon            1..39
                     /gene="RPL29"
                     /gene_synonym="eL29; HIP; HUMRPL29; L29; RPL29P10;
                     RPL29_3_370"
                     /inference="alignment:Splign:2.1.0"
     exon            40..84
                     /gene="RPL29"
                     /gene_synonym="eL29; HIP; HUMRPL29; L29; RPL29P10;
                     RPL29_3_370"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..527
                     /gene="RPL29"
                     /gene_synonym="eL29; HIP; HUMRPL29; L29; RPL29P10;
                     RPL29_3_370"
                     /note="heparin/heparan sulfate-interacting protein;
                     HP/HS-interacting protein; heparin/heparan sulfate-binding
                     protein; cell surface heparin-binding protein HIP; 60S
                     ribosomal protein L29; ribosomal protein YL43 homologue"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL29"
                     /protein_id="NP_000983.1"
                     /db_xref="CCDS:CCDS2845.1"
                     /db_xref="GeneID:6159"
                     /db_xref="HGNC:HGNC:10331"
                     /db_xref="MIM:601832"
                     /translation="MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMR
                     FAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHP
                     KLGKRARARIAKGLRLCRPKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE"
     exon            85..149
                     /gene="RPL29"
                     /gene_synonym="eL29; HIP; HUMRPL29; L29; RPL29P10;
                     RPL29_3_370"
                     /inference="alignment:Splign:2.1.0"
     exon            150..754
                     /gene="RPL29"
                     /gene_synonym="eL29; HIP; HUMRPL29; L29; RPL29P10;
                     RPL29_3_370"
                     /inference="alignment:Splign:2.1.0"
     regulatory      631..636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL29"
                     /gene_synonym="eL29; HIP; HUMRPL29; L29; RPL29P10;
                     RPL29_3_370"
                     /note="hexamer: AATAAA"
     polyA_site      676
                     /gene="RPL29"
                     /gene_synonym="eL29; HIP; HUMRPL29; L29; RPL29P10;
                     RPL29_3_370"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccggt tctaggcgct tcgggagccg cggcttatgg tgcagacatg gccaagtcca
       61 agaaccacac cacacacaac cagtcccgaa aatggcacag aaatggtatc aagaaacccc
      121 gatcacaaag atacgaatct cttaaggggg tggaccccaa gttcctgagg aacatgcgct
      181 ttgccaagaa gcacaacaaa aagggcctaa agaagatgca ggccaacaat gccaaggcca
      241 tgagtgcacg tgccgaggct atcaaggccc tcgtaaagcc caaggaggtt aagcccaaga
      301 tcccaaaggg tgtcagccgc aagctcgatc gacttgccta cattgcccac cccaagcttg
      361 ggaagcgtgc tcgtgcccgt attgccaagg ggctcaggct gtgccggcca aaggccaagg
      421 ccaaggccaa ggccaaggat caaaccaagg cccaggctgc agccccagct tcagttccag
      481 ctcaggctcc caaacgtacc caggccccta caaaggcttc agagtagata tctctgccaa
      541 catgaggaca gaaggactgg tgcgaccccc cacccccgcc cctgggctac catctgcatg
      601 gggctggggt cctcctgtgc tatttgtaca aataaacctg aggcaggatt tgttagcctc
      661 tgtctatgat cctggggatg ggtttggttg ctccatctgt tggtgtggga gaagacatgg
      721 gtctggatgg tggggtgtgg gtgggagtca ggag
//
