LOCUS       NM_000990               4535 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ribosomal protein L27a (RPL27A), mRNA.
ACCESSION   NM_000990
VERSION     NM_000990.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4535)
  AUTHORS   Xing,H., Jiang,X., Yang,C., Tan,B., Hu,J. and Zhang,M.
  TITLE     High expression of RPL27A predicts poor prognosis in patients with
            hepatocellular carcinoma
  JOURNAL   World J Surg Oncol 21 (1), 209 (2023)
   PUBMED   37474947
  REMARK    GeneRIF: High expression of RPL27A predicts poor prognosis in
            patients with hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4535)
  AUTHORS   Zhang,Z., Liu,Z., Zhao,W., Zhao,X. and Tao,Y.
  TITLE     tRF-19-W4PU732S promotes breast cancer cell malignant activity by
            targeting inhibition of RPL27A (ribosomal protein-L27A)
  JOURNAL   Bioengineered 13 (2), 2087-2098 (2022)
   PUBMED   35030975
  REMARK    GeneRIF: tRF-19-W4PU732S promotes breast cancer cell malignant
            activity by targeting inhibition of RPL27A (ribosomal
            protein-L27A).
REFERENCE   3  (bases 1 to 4535)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4535)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 4535)
  AUTHORS   Alkhatabi,H.A., McLornan,D.P., Kulasekararaj,A.G., Malik,F.,
            Seidl,T., Darling,D., Gaken,J. and Mufti,G.J.
  TITLE     RPL27A is a target of miR-595 and may contribute to the
            myelodysplastic phenotype through ribosomal dysgenesis
  JOURNAL   Oncotarget 7 (30), 47875-47890 (2016)
   PUBMED   27374104
  REMARK    GeneRIF: RPL27A overexpression, despite showing no significant
            effects on p53 mRNA levels, did in fact enhance cellular
            proliferation. In normal CD34+ cells, RPL27A knockdown
            preferentially blocked erythroid proliferation and differentiation.
REFERENCE   6  (bases 1 to 4535)
  AUTHORS   Bortoluzzi,S., d'Alessi,F., Romualdi,C. and Danieli,G.A.
  TITLE     Differential expression of genes coding for ribosomal proteins in
            different human tissues
  JOURNAL   Bioinformatics 17 (12), 1152-1157 (2001)
   PUBMED   11751223
REFERENCE   7  (bases 1 to 4535)
  AUTHORS   Kusuda,J., Hirai,M., Tanuma,R., Hirata,M. and Hashimoto,K.
  TITLE     Genomic structure and chromosome location of RPL27A/Rpl27a, the
            genes encoding human and mouse ribosomal protein L27A
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 248-251 (1999)
   PUBMED   10449908
REFERENCE   8  (bases 1 to 4535)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   9  (bases 1 to 4535)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 4535)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim Biophys Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AI809856.1, BC020169.1, AC091053.11 and BC004284.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000990.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L15P family of ribosomal proteins. It is located in the
            cytoplasm. Variable expression of this gene in colorectal cancers
            compared to adjacent normal tissues has been observed, although no
            correlation between the level of expression and the severity of the
            disease has been found. As is typical for genes encoding ribosomal
            proteins, multiple processed pseudogenes derived from this gene are
            dispersed through the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.73358.1,
                                           SRR1803611.60005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314138.11/ ENSP00000346015.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AI809856.1         1-118               c
            119-1499            BC020169.1         95-1475
            1500-3360           AC091053.11        128877-130737       c
            3361-4535           BC004284.1         1017-2191
FEATURES             Location/Qualifiers
     source          1..4535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4535
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /note="ribosomal protein L27a"
                     /db_xref="GeneID:6157"
                     /db_xref="HGNC:HGNC:10329"
                     /db_xref="MIM:603637"
     exon            1..25
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..469
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L27a"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL15"
                     /protein_id="NP_000981.1"
                     /db_xref="CCDS:CCDS7790.1"
                     /db_xref="GeneID:6157"
                     /db_xref="HGNC:HGNC:10329"
                     /db_xref="MIM:603637"
                     /translation="MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRIN
                     FDKYHPGYFGKVGMKHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPIID
                     VVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKSVGGACVLVA"
     exon            26..89
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /inference="alignment:Splign:2.1.0"
     exon            90..165
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /inference="alignment:Splign:2.1.0"
     exon            166..340
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /inference="alignment:Splign:2.1.0"
     exon            341..4535
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      490..495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /note="hexamer: ATTAAA"
     polyA_site      511
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /note="major polyA site"
     regulatory      692..697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /note="hexamer: AATAAT"
     polyA_site      715
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
     regulatory      1484..1489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /note="hexamer: ATTATA"
     polyA_site      1510
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /note="hexamer: ATTAAA"
     polyA_site      2193
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
     regulatory      4280..4285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /note="hexamer: AATAAA"
     polyA_site      4308
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
     regulatory      4519..4524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
                     /note="hexamer: AACAAA"
     polyA_site      4535
                     /gene="RPL27A"
                     /gene_synonym="L27A; uL15"
ORIGIN      
        1 ctttttcgtc tgggctgcca acatgccatc cagactgagg aagacccgga aacttagggg
       61 ccacgtgagc cacggccacg gccgcatagg caagcaccgg aagcaccccg gcggccgcgg
      121 taatgctggt ggtctgcatc accaccggat caacttcgac aaataccacc caggctactt
      181 tgggaaagtt ggtatgaagc attaccactt aaagaggaac cagagcttct gcccaactgt
      241 caaccttgac aaattgtgga ctttggtcag tgaacagaca cgggtgaatg ctgctaaaaa
      301 caagactggg gctgctccca tcattgatgt ggtgcgatcg ggctactaca aagttctggg
      361 aaagggaaag ctcccaaagc agcctgtcat cgtgaaggcc aaattcttca gcagaagagc
      421 tgaggagaag attaagagtg ttgggggggc ctgtgtcctg gtggcttgaa gccacatgga
      481 gggagtttca ttaaatgcta actacttttt ccttgtggtg tgagtgtagg ttcttcagtg
      541 gcacctctac atcctgtgtg cattgggagc ccaggttcta gtacttaggg tatgaagaca
      601 tggggtcctc tcctgacttc cctcaaatat atggtaaacg taagaccaac acagacgttg
      661 gccagttaaa catttctgtt tataaagtca gaataatacc tgttgatcac tgaaaggcct
      721 gcatgtattg tactctgaat tttacagtga atgagagaat gtaccctaat tgttcaacag
      781 ggctcaaaag gaaagattcc attttgatgg gtcacattct aaagaggggc agtgtgatag
      841 gaatgagatg gtcctttagg acttaagttc tcagcccaag gtttttccac gtggccccct
      901 catctttttt ttttttttaa acggagtctc tcttgccagg ctggagtgca gtggcacgat
      961 ctcggctcac tgcagcctcc gcctcccagg ttaagcgatt ctcctgcctc agcttcctga
     1021 ctaactggga ttacaggcgc ccaccaccat gcccagctaa tttttgtatt ttcagtagag
     1081 atggggtttc accatgttgg ccatgctggt ctctaactcc taacctcaag tgatctgccc
     1141 acatcggcct ccaaaagttc tgggattata gtgtgagcca ctgcgcccgg ccatggctcc
     1201 ttaatcttga tccaaattat tgttacatcc agaatgtgat gaatcaaaat ctcgagatgg
     1261 gggtccagca atctgaaatt tcagtatgcc agggcttttc tgtatgtcaa agtgggtttg
     1321 aaatagttaa tttttcttct agtctgaaat gtatcgggaa aatttggaaa tcctgaaggc
     1381 tggaaattga aataagtttt tctaggattt gtgtctcttg ctattggaaa actgatggtg
     1441 accaattcat gtttacaaat aagatcctca tagatctcgg taaattataa tttgctacag
     1501 ttttatggtt cttcctgtga ttttgagctt tttttgaccc aaaataatac agtctaaaac
     1561 tatagacaaa taagatggca cttagactcc tgggttttag ttagtggagg tttccttagt
     1621 gcactgtggg gtcataataa gccgagaacc atggctgtct atgggacaca tctgtcagga
     1681 caacctttag aggatgttgg ggatcaaata gaaggcacag agaagcactg aattggctta
     1741 cataagaata ggctagaatt acaagtagtg aaacctcgat tcagctggac aattttaaac
     1801 aaatgtatca tttggcttgt atcttctgtt gtgctggaga agttagaaat aagggctctc
     1861 cagaccagcc tgaccaacct ggagaaacct tgtctctact aaatacacaa aattagccag
     1921 gcgtggtggc acatgcctgt aatcccagct actttggagg ctgagccagg agaatctcca
     1981 ggaggcggag gttgctgtga gccgagatcg tgccattgca ctccagcttg ggcaacaaga
     2041 gtgaaactct gtccaccccc cccaaaaaaa gtaagggctc tccattaggg cccatagagg
     2101 acttgtaata tggaacctga atccaaggat cccacaataa gtggtcagta gttcatgatg
     2161 aattaaaaga ctcaatattt ggtcttcacc caatacctgt gtgactttta gtcctaattt
     2221 cctcatcttt aaaatttcag tgaaagtgcc tacctgagga ttgtgtagat taaaatggaa
     2281 accgtgcact taattttttg ttttgttttg agacggagtc tcgctctgtc gcccaggctg
     2341 gagtgcagtg gtgcgatctc agatcactgc aagctccgcc tcctaggttc agaccattct
     2401 cctgcctcag cttcccaagt agctgggact acaggcgccc gccactgcgc ccggctaatt
     2461 ttttgcattt ttagtagaga cagggtttca ccgtgttagc caggatggtc tcgatctcct
     2521 gatctgcccg cctcagcctc ccaaagtgct gggattacag gcatgagcca ccgcgcccgg
     2581 cccaggcact taatttttgt gtttgactta gtaacttaag tgcaaactat tacgggagca
     2641 gatggagtca attggccttc atgtgattgt cagtgggaaa ttggtccaag cagagggaat
     2701 actggttcag gaaactggtt tgggaaggtt aggcaaacgg gaagtgctat ggtggagaga
     2761 aagattactc tggccgggct gtaaaggacg gctacaatgg gaggctgaag gcagaaccaa
     2821 gaaaatggga gtgagtatgg aaaaggtacg attcagacgg cataatggac gggacttgga
     2881 gactgaattg tagtgggccg accacaaaat gataaggcat ggaaggaagt agagtttggg
     2941 gggaaggatc cctagtccct taatggctac cttcttcccc aggagttgtt aggccatccg
     3001 atcccctggc ctgggaaaga aacactgatt tcgttgctgg cttgttcact caccagaagc
     3061 tacagctact aacagttcta aaaactgttt catgtgatga ggaacagacg aaaatagttt
     3121 tgagccctaa gtccgccgat tccagtgctt tcttgaaccc gcatttacta aaatattttc
     3181 atgactgcca agctttgaat agcctgctgt gttcatggag gctcatactg gcgatctcta
     3241 gtggctggct aaagcttgaa ttgcaaaaga tctaatttct ggtctaatgt atatatgcct
     3301 taaatatagt tgcgttcaaa cgtgggagct gcaggtgcaa cttgatttta tgacaaatgg
     3361 ctgccacata atttgcacaa gcagtgctcg tcaagggcag ctaaatcagg cgagctttca
     3421 atcaaaataa atgtactact aaaccctact tagcggctaa ctagcccaag agcagacagc
     3481 ccacggacgg actgcaagtc ggaagcgcgg gcggaagctg tgcagcgccc acctggtggc
     3541 tccatcggcc gcgttcatca gtcagcacga cccgacctca gtggcgtcct cacaacacag
     3601 accggacctt gggtcttacc ccggcacctg agaaccactt ccggtgagta gcttctactt
     3661 ccggagacga tgactccccc gcgtcccaga ccggaagaag cccggcggag accggcctcg
     3721 ctcggccact tccggcaagg gcggagccgg ccagtggtgc gcgagcgcag ataactcccc
     3781 tggagaggcg ggatgttcaa ctccacccct ggtccttggg cggccgtggg tccccttcga
     3841 agcggaggaa tggccaacct cgccgcactt cgagcccctt tagggtgcgt ttaagaacag
     3901 tgggcgtggc ctttacgtaa atcttcgaga tgggaacctc cagaatttgt ctcaattgtc
     3961 taaaaggtaa tgagcgtcag cgacattcaa gggcactttg ggctaaaaaa gaaagtgctt
     4021 gtacacggat ggaaatattc tagaagaaca taaaaggaat ttcctcttag gaggttaggg
     4081 aaatgagcac gaagtatgtt ttggtgcagt tttttgttca acccaatgcg tattttcata
     4141 ttgagaggca atataaatgg agcgaaagta tcttgagaaa aaaaaaaaaa ctaccagaac
     4201 ttgccgttgc tgaaaagtaa tattttctct ttcgagagtt ttcatggcct tttaaattac
     4261 acccccacct ccacaggcaa ataaatttgt tttggaatgc ataccacatc atctggctct
     4321 agaaacgtat tttgtgtagc tcccctagca agaatatagg ttaaagcgta aatttaattc
     4381 ctggctctat tttacatccc aatttttatt ttcctctcat tcccacttta cgttgtttca
     4441 aataacctag tttgtgtatc cctgtaagtc attttggtat aaagtaggtt ataagtgtac
     4501 atgcgaaaag atgtttttaa caaaaatgta actga
//
