LOCUS       NM_000988                505 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L27 (RPL27), transcript variant 1,
            mRNA.
ACCESSION   NM_000988
VERSION     NM_000988.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Suo,L., Gao,M., Ma,T. and Gao,Z.
  TITLE     Effect of RPL27 knockdown on the proliferation and apoptosis of
            human liver cancer cells
  JOURNAL   Biochem Biophys Res Commun 682, 156-162 (2023)
   PUBMED   37812860
  REMARK    GeneRIF: Effect of RPL27 knockdown on the proliferation and
            apoptosis of human liver cancer cells.
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Park,S.Y., Seo,D., Jeon,E.H., Park,J.Y., Jang,B.C., Kim,J.I.,
            Im,S.S., Lee,J.H., Kim,S., Cho,C.H. and Lee,Y.H.
  TITLE     RPL27 contributes to colorectal cancer proliferation and stemness
            via PLK1 signaling
  JOURNAL   Int J Oncol 63 (2) (2023)
   PUBMED   37387446
  REMARK    GeneRIF: RPL27 contributes to colorectal cancer proliferation and
            stemness via PLK1 signaling.
REFERENCE   3  (bases 1 to 505)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 505)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 505)
  AUTHORS   Zhang,Y., You,J., Wang,X. and Weber,J.
  TITLE     The DHX33 RNA Helicase Promotes mRNA Translation Initiation
  JOURNAL   Mol Cell Biol 35 (17), 2918-2931 (2015)
   PUBMED   26100019
REFERENCE   6  (bases 1 to 505)
  AUTHORS   Harshman,K., Bell,R., Rosenthal,J., Katcher,H., Miki,Y.,
            Swenson,J., Gholami,Z., Frye,C., Ding,W., Dayananth,P. et al.
  TITLE     Comparison of the positional cloning methods used to isolate the
            BRCA1 gene
  JOURNAL   Hum Mol Genet 4 (8), 1259-1266 (1995)
   PUBMED   7581362
REFERENCE   7  (bases 1 to 505)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   8  (bases 1 to 505)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
REFERENCE   9  (bases 1 to 505)
  AUTHORS   Gallagher,R.A., McClean,P.M. and Malik,A.N.
  TITLE     Cloning and nucleotide sequence of a full length cDNA encoding
            ribosomal protein L27 from human fetal kidney
  JOURNAL   Biochim Biophys Acta 1217 (3), 329-332 (1994)
   PUBMED   8148381
REFERENCE   10 (bases 1 to 505)
  AUTHORS   Jones,K.W., Chevrette,M., Shapero,M.H. and Fournier,R.E.
  TITLE     Generation of region- and species-specific expressed gene probes
            from somatic cell hybrids
  JOURNAL   Nat Genet 1 (4), 278-283 (1992)
   PUBMED   1302024
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC055866.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 8, 2018 this sequence version replaced NM_000988.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of four RNA species and approximately
            80 structurally distinct proteins. This gene encodes a member of
            the L27e family of ribosomal proteins and a component of the 60S
            subunit. A splice site mutation in this gene has been identified in
            a Diamond-Blackfan anemia (DBA) patient. As is typical for genes
            encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) encodes the protein. Variants
            1-3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG618850.1, SRR1163657.220571.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253788.12/ ENSP00000253788.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC055866.19        182710-182762
            54-136              AC055866.19        183040-183122
            137-306             AC055866.19        184224-184393
            307-417             AC055866.19        186964-187074
            418-505             AC055866.19        187163-187250
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..505
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /note="ribosomal protein L27"
                     /db_xref="GeneID:6155"
                     /db_xref="HGNC:HGNC:10328"
                     /db_xref="MIM:607526"
     exon            1..53
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /inference="alignment:Splign:2.1.0"
     exon            54..136
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..466
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L27"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL27"
                     /protein_id="NP_000979.1"
                     /db_xref="CCDS:CCDS11449.1"
                     /db_xref="GeneID:6155"
                     /db_xref="HGNC:HGNC:10328"
                     /db_xref="MIM:607526"
                     /translation="MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVA
                     GIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFR
                     DPALKRKARREAKVKFEERYKTGKNKWFFQKLRF"
     exon            137..306
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /inference="alignment:Splign:2.1.0"
     exon            307..417
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /inference="alignment:Splign:2.1.0"
     exon            418..505
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      483..488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /note="hexamer: ATTAAA"
     polyA_site      505
                     /gene="RPL27"
                     /gene_synonym="DBA16; eL27; L27"
                     /note="major polyA site"
ORIGIN      
        1 agcggaagtg tccttctttc ctttttgctg gtagggccgg gtggttgctg ccgaaatggg
       61 caagttcatg aaacctggga aggtggtgct tgtcctggct ggacgctact ccggacgcaa
      121 agctgtcatc gtgaagaaca ttgatgatgg cacctcagat cgcccctaca gccatgctct
      181 ggtggctgga attgaccgct acccccgcaa agtgacagct gccatgggca agaagaagat
      241 cgccaagaga tcaaagataa aatcttttgt gaaagtgtat aactacaatc acctaatgcc
      301 cacaaggtac tctgtggata tccccttgga caaaactgtc gtcaataagg atgtcttcag
      361 agatcctgct cttaaacgca aggcccgacg ggaggccaag gtcaagtttg aagagagata
      421 caagacaggc aagaacaagt ggttcttcca gaaactgcgg ttttagatgc tttgttttga
      481 tcattaaaaa ttataaagaa aaaaa
//
