LOCUS       NM_000987                528 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens ribosomal protein L26 (RPL26), transcript variant 2,
            mRNA.
ACCESSION   NM_000987
VERSION     NM_000987.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Chen,J., Crutchley,J., Zhang,D., Owzar,K. and Kastan,M.B.
  TITLE     Identification of a DNA Damage-Induced Alternative Splicing Pathway
            That Regulates p53 and Cellular Senescence Markers
  JOURNAL   Cancer Discov 7 (7), 766-781 (2017)
   PUBMED   28288992
  REMARK    GeneRIF: ionizing radiation (IR) inhibits the activity of SMG1, a
            phosphoinositide-3-kinase-like kinase family member, reducing the
            binding of SMG1 to a specific region near exon 9 of p53 precursor
            mRNA and promoting the binding of ribosomal protein L26 (RPL26) to
            p53 pre-mRNA
REFERENCE   3  (bases 1 to 528)
  AUTHORS   Zhang,M., Zhang,J., Yan,W. and Chen,X.
  TITLE     p73 expression is regulated by ribosomal protein RPL26 through mRNA
            translation and protein stability
  JOURNAL   Oncotarget 7 (48), 78255-78268 (2016)
   PUBMED   27825141
  REMARK    GeneRIF: In colorectal tumor cells RPL26 regulates p73 expression
            via two distinct mechanisms: protein stability and mRNA
            translation.
REFERENCE   4  (bases 1 to 528)
  AUTHORS   Sung,M.K., Porras-Yakushi,T.R., Reitsma,J.M., Huber,F.M.,
            Sweredoski,M.J., Hoelz,A., Hess,S. and Deshaies,R.J.
  TITLE     A conserved quality-control pathway that mediates degradation of
            unassembled ribosomal proteins
  JOURNAL   Elife 5, e19105 (2016)
   PUBMED   27552055
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 528)
  AUTHORS   Towers,C.G. and Ford,H.L.
  TITLE     A tale of two ends
  JOURNAL   Cell Cycle 15 (12), 1523-1524 (2016)
   PUBMED   27101085
REFERENCE   6  (bases 1 to 528)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 528)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 528)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   9  (bases 1 to 528)
  AUTHORS   Zaman,G.J.
  TITLE     Sequence of a cDNA encoding human ribosomal protein L26 and of a
            cDNA probably encoding human ribosomal protein L6
  JOURNAL   Nucleic Acids Res 21 (7), 1673 (1993)
   PUBMED   8479925
REFERENCE   10 (bases 1 to 528)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AK311804.1, BC071664.1 and BM928617.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 8, 2018 this sequence version replaced NM_000987.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L24P family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. Mutations in this gene result in
            Diamond-Blackfan anemia. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB121782.1, BU600257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648839.1/ ENSP00000498177.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AK311804.1         1-480
            481-521             BC071664.1         470-510
            522-528             BM928617.1         503-509
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..528
                     /gene="RPL26"
                     /gene_synonym="DBA11; L26; uL24"
                     /note="ribosomal protein L26"
                     /db_xref="GeneID:6154"
                     /db_xref="HGNC:HGNC:10327"
                     /db_xref="MIM:603704"
     exon            1..37
                     /gene="RPL26"
                     /gene_synonym="DBA11; L26; uL24"
                     /inference="alignment:Splign:2.1.0"
     exon            38..210
                     /gene="RPL26"
                     /gene_synonym="DBA11; L26; uL24"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..480
                     /gene="RPL26"
                     /gene_synonym="DBA11; L26; uL24"
                     /note="60S ribosomal protein L26"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL24"
                     /protein_id="NP_000978.1"
                     /db_xref="CCDS:CCDS11142.1"
                     /db_xref="GeneID:6154"
                     /db_xref="HGNC:HGNC:10327"
                     /db_xref="MIM:603704"
                     /translation="MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNV
                     RSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPS
                     KVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE"
     exon            211..351
                     /gene="RPL26"
                     /gene_synonym="DBA11; L26; uL24"
                     /inference="alignment:Splign:2.1.0"
     exon            352..528
                     /gene="RPL26"
                     /gene_synonym="DBA11; L26; uL24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      504..509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL26"
                     /gene_synonym="DBA11; L26; uL24"
                     /note="hexamer: ATTAAA"
     polyA_site      523
                     /gene="RPL26"
                     /gene_synonym="DBA11; L26; uL24"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccctt ttgcggccat caccgaagcg ggagcggcca aaatgaagtt taatcccttt
       61 gtgacttccg accgaagcaa gaatcgcaaa aggcatttca atgcaccttc ccacattcga
      121 aggaagatta tgtcttcccc tctttccaaa gagctgagac agaagtacaa cgtgcgatcc
      181 atgcccatcc gaaaggatga tgaagttcag gttgtacgtg gacactataa aggtcagcaa
      241 attggcaaag tagtccaggt ttacaggaag aaatatgtta tctacattga acgggtgcag
      301 cgggaaaagg ctaatggcac aactgtccac gtaggcattc accccagcaa ggtggttatc
      361 actaggctaa aactggacaa agaccgcaaa aagatcctcg aacggaaagc caaatctcgc
      421 caagtaggaa aggaaaaggg caaatacaag gaagaaacca ttgagaagat gcaggaataa
      481 agtaatctta tatacaagct ttgattaaaa cttgaaacaa agagcctg
//
