LOCUS       NM_000986                560 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ribosomal protein L24 (RPL24), mRNA.
ACCESSION   NM_000986
VERSION     NM_000986.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 560)
  AUTHORS   Tzur,Y., Dubnov,S., Madrer,N., Bar,A., Nadorp,B., Mishra,N.,
            Heppenstall,P., Bennett,E.R., Greenberg,D.S., Winek,K. and Soreq,H.
  TITLE     Ribosomal protein L24 mediates mammalian microRNA processing in an
            evolutionarily conserved manner
  JOURNAL   Cell Mol Life Sci 81 (1), 55 (2024)
   PUBMED   38261097
  REMARK    GeneRIF: Ribosomal protein L24 mediates mammalian microRNA
            processing in an evolutionarily conserved manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 560)
  AUTHORS   Challa,S., Khulpateea,B.R., Nandu,T., Camacho,C.V., Ryu,K.W.,
            Chen,H., Peng,Y., Lea,J.S. and Kraus,W.L.
  TITLE     Ribosome ADP-ribosylation inhibits translation and maintains
            proteostasis in cancers
  JOURNAL   Cell 184 (17), 4531-4546 (2021)
   PUBMED   34314702
REFERENCE   3  (bases 1 to 560)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 560)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   5  (bases 1 to 560)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 560)
  AUTHORS   Uechi,T., Tanaka,T. and Kenmochi,N.
  TITLE     A complete map of the human ribosomal protein genes: assignment of
            80 genes to the cytogenetic map and implications for human
            disorders
  JOURNAL   Genomics 72 (3), 223-230 (2001)
   PUBMED   11401437
REFERENCE   7  (bases 1 to 560)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 560)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 560)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
REFERENCE   10 (bases 1 to 560)
  AUTHORS   Johnson,K.R.
  TITLE     Characterization of cDNA clones encoding the human homologue of
            Saccharomyces cerevisiae ribosomal protein L30
  JOURNAL   Gene 123 (2), 283-285 (1993)
   PUBMED   8428672
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BU754101.1, M94314.1 and CD513036.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000986.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L24E family of ribosomal proteins. It is located in the
            cytoplasm. This gene has been referred to as ribosomal protein L30
            because the encoded protein shares amino acid identity with the L30
            ribosomal proteins from S. cerevisiae; however, its official name
            is ribosomal protein L24. As is typical for genes encoding
            ribosomal proteins, there are multiple processed pseudogenes of
            this gene dispersed through the genome. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM772472.1, BM997631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394077.8/ ENSP00000377640.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BU754101.1         10-14
            6-559               M94314.1           3-556
            560-560             CD513036.1         547-547
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.3"
     gene            1..560
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /note="ribosomal protein L24"
                     /db_xref="GeneID:6152"
                     /db_xref="HGNC:HGNC:10325"
                     /db_xref="MIM:604180"
     exon            1..47
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..516
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /note="60S ribosomal protein L24; epididymis secretory
                     protein Li 310; ribosomal protein L30; 60S ribosomal
                     protein L30"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL24"
                     /protein_id="NP_000977.1"
                     /db_xref="CCDS:CCDS33809.1"
                     /db_xref="GeneID:6152"
                     /db_xref="HGNC:HGNC:10325"
                     /db_xref="MIM:604180"
                     /translation="MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKR
                     NPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRK
                     AQREQAIRAAKEAKKAKQASKKTAMAAAKAPTKAAPKQKIVKPVKVSAPRVGGKR"
     exon            48..123
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /inference="alignment:Splign:2.1.0"
     exon            124..234
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /inference="alignment:Splign:2.1.0"
     exon            235..371
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /inference="alignment:Splign:2.1.0"
     exon            372..435
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /inference="alignment:Splign:2.1.0"
     exon            436..560
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      537..542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /note="hexamer: AATAAA"
     polyA_site      560
                     /gene="RPL24"
                     /gene_synonym="eL24; HEL-S-310; L24"
                     /note="major polyA site"
ORIGIN      
        1 ctttcttttc gccatctttt gtctttccgt ggagctgtcg ccatgaaggt cgagctgtgc
       61 agttttagcg ggtacaagat ctaccccgga cacgggaggc gctacgccag gaccgacggg
      121 aaggttttcc agtttcttaa tgcgaaatgc gagtcggctt tcctttccaa gaggaatcct
      181 cggcagataa actggactgt cctctacaga aggaagcaca aaaagggaca gtcggaagaa
      241 attcaaaaga aaagaacccg ccgagcagtc aaattccaga gggccattac tggtgcatct
      301 cttgctgata taatggccaa gaggaatcag aaacctgaag ttagaaaggc tcaacgagaa
      361 caagctatca gggctgctaa ggaagcaaaa aaggctaagc aagcatctaa aaagactgca
      421 atggctgctg ctaaggcacc tacaaaggca gcacctaagc aaaagattgt gaagcctgtg
      481 aaagtttcag ctccccgagt tggtggaaaa cgctaaactg gcagattaga tttttaaata
      541 aagattggat tataactcta
//
