LOCUS       NM_000984                970 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L23a (RPL23A), mRNA.
ACCESSION   NM_000984 XM_208300
VERSION     NM_000984.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Zhang,Z., Wu,Q., Fang,M., Liu,Y., Jiang,J., Feng,Q., Hu,R. and
            Xu,J.
  TITLE     HERC3 directly targets RPL23A for ubiquitination degradation and
            further regulates Colorectal Cancer proliferation and the cell
            cycle
  JOURNAL   Int J Biol Sci 18 (8), 3282-3297 (2022)
   PUBMED   35637966
  REMARK    GeneRIF: HERC3 directly targets RPL23A for ubiquitination
            degradation and further regulates Colorectal Cancer proliferation
            and the cell cycle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 970)
  AUTHORS   Jakel,S. and Gorlich,D.
  TITLE     Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear
            import of ribosomal proteins in mammalian cells
  JOURNAL   EMBO J 17 (15), 4491-4502 (1998)
   PUBMED   9687515
REFERENCE   7  (bases 1 to 970)
  AUTHORS   Fan,W., Christensen,M., Eichler,E., Zhang,X. and Lennon,G.
  TITLE     Cloning, sequencing, gene organization, and localization of the
            human ribosomal protein RPL23A gene
  JOURNAL   Genomics 46 (2), 234-239 (1997)
   PUBMED   9417910
REFERENCE   8  (bases 1 to 970)
  AUTHORS   Jiang,H., Lin,J.J., Tao,J. and Fisher,P.B.
  TITLE     Suppression of human ribosomal protein L23A expression during cell
            growth inhibition by interferon-beta
  JOURNAL   Oncogene 14 (4), 473-480 (1997)
   PUBMED   9053844
REFERENCE   9  (bases 1 to 970)
  AUTHORS   Fan,W., Cai,W., Parimoo,S., Schwarz,D.C., Lennon,G.G. and
            Weissman,S.M.
  TITLE     Identification of seven new human MHC class I region genes around
            the HLA-F locus
  JOURNAL   Immunogenetics 44 (2), 97-103 (1996)
   PUBMED   8662070
  REMARK    Erratum:[Immunogenetics 1997;46(2):169]
REFERENCE   10 (bases 1 to 970)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from U43701.1, BC058041.1, BE464375.1 and AC010761.10.
            
            On Nov 22, 2018 this sequence version replaced NM_000984.5.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L23P family of ribosomal proteins. It is located in the
            cytoplasm. The protein may be one of the target molecules involved
            in mediating growth inhibition by interferon. In yeast, the
            corresponding protein binds to a specific site on the 26S rRNA.
            This gene is co-transcribed with the U42A, U42B, U101A, and U101B
            small nucleolar RNA genes, which are located in its third, first,
            second, and fourth introns, respectively. As is typical for genes
            encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.26679.1,
                                           SRR5189661.13134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422514.7/ ENSP00000389103.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               U43701.1           1-546
            547-959             BC058041.1         546-958
            960-967             BE464375.1         17-24               c
            968-970             AC010761.10        76509-76511
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..970
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /note="ribosomal protein L23a"
                     /db_xref="GeneID:6147"
                     /db_xref="HGNC:HGNC:10317"
                     /db_xref="MIM:602326"
     exon            1..46
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..492
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /note="60S ribosomal protein L23a; melanoma
                     differentiation-associated gene 20"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL23"
                     /protein_id="NP_000975.2"
                     /db_xref="CCDS:CCDS11241.1"
                     /db_xref="GeneID:6147"
                     /db_xref="HGNC:HGNC:10317"
                     /db_xref="MIM:602326"
                     /translation="MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSP
                     TFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDV
                     KANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII"
     exon            47..230
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /inference="alignment:Splign:2.1.0"
     exon            231..407
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /inference="alignment:Splign:2.1.0"
     exon            408..477
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /inference="alignment:Splign:2.1.0"
     exon            478..970
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      517..522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /note="hexamer: AATATA"
     polyA_site      549
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /note="major polyA site"
     regulatory      943..948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
                     /note="hexamer: AATAAA"
     polyA_site      970
                     /gene="RPL23A"
                     /gene_synonym="L23A; MDA20; uL23"
ORIGIN      
        1 attggagacc cttttcacaa gatggcgccg aaagcgaaga aggaagctcc tgcccctcct
       61 aaagctgaag ccaaagcgaa ggctttaaag gccaagaagg cagtgttgaa aggtgtccac
      121 agccacaaaa agaagaagat ccgcacgtca cccaccttcc ggcggccgaa gacactgcga
      181 ctccggagac agcccaaata tcctcggaag agcgctccca ggagaaacaa gcttgaccac
      241 tatgctatca tcaagtttcc gctgaccact gagtctgcca tgaagaagat agaagacaac
      301 aacacacttg tgttcattgt ggatgttaaa gccaacaagc accagattaa acaggctgtg
      361 aagaagctgt atgacattga tgtggccaag gtcaacaccc tgattcggcc tgatggagag
      421 aagaaggcat atgttcgact ggctcctgat tacgatgctt tggatgttgc caacaaaatt
      481 gggatcatct aaactgagtc cagctgccta attctgaata tatatatata tatatctttt
      541 caccatatac atgcctgtct gtcaatttct ggttgggctg ggaggccaca cacacacact
      601 gacatgacag ggcttgggca agactcctgt tctacttatc cttttgaaat acctcaccct
      661 gccactccac catgtatgat cattccagag atctttgtga ctagagttag tgtcctagga
      721 aaaccagaac tcagaacttg cctccatggt tgagtaacaa gctgtacaag aacccctttt
      781 atccctggaa gaggctgtgt atgaaaccaa tgcccagggt ttgaagggtg ttagcatcca
      841 tttcagggga gtgtggattg gctggctctc tggtagcatt ttgtcctcac acacccatct
      901 actatgtcca accggtctgt ctgcttccct caccccttgc ccaataaagg acaaggactt
      961 cagaggagta
//
