LOCUS       NM_000978               2706 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L23 (RPL23), mRNA.
ACCESSION   NM_000978
VERSION     NM_000978.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2706)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2706)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 2706)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 2706)
  AUTHORS   Yaseen,N.R. and Blobel,G.
  TITLE     Cloning and characterization of human karyopherin beta3
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4451-4456 (1997)
   PUBMED   9114010
REFERENCE   8  (bases 1 to 2706)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 2706)
  AUTHORS   Herault,Y., Michel,D., Chatelain,G. and Brun,G.
  TITLE     cDNA and predicted amino acid sequences of the human ribosomal
            protein genes rpS12 and rpL17
  JOURNAL   Nucleic Acids Res 19 (14), 4001 (1991)
   PUBMED   1861993
REFERENCE   10 (bases 1 to 2706)
  AUTHORS   Berchtold,M.W. and Berger,M.C.
  TITLE     Isolation and analysis of a human cDNA highly homologous to the
            yeast gene encoding L17A ribosomal protein
  JOURNAL   Gene 102 (2), 283-288 (1991)
   PUBMED   1874450
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from X55954.1, CA437923.1 and AC110749.12.
            
            On Nov 22, 2018 this sequence version replaced NM_000978.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L14P family of ribosomal proteins. It is located in the
            cytoplasm. This gene has been referred to as rpL17 because the
            encoded protein shares amino acid identity with ribosomal protein
            L17 from Saccharomyces cerevisiae; however, its official symbol is
            RPL23. As is typical for genes encoding ribosomal proteins, there
            are multiple processed pseudogenes of this gene dispersed through
            the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB133887.1, SRR1803614.109555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000479035.7/ ENSP00000420311.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               X55954.1           2-468
            468-498             CA437923.1         487-517
            499-2706            AC110749.12        25459-27666
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2706
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /note="ribosomal protein L23"
                     /db_xref="GeneID:9349"
                     /db_xref="HGNC:HGNC:10316"
                     /db_xref="MIM:603662"
     exon            1..24
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..434
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /note="60S ribosomal protein L23; ribosomal protein L17;
                     60S ribosomal protein L17"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL14"
                     /protein_id="NP_000969.1"
                     /db_xref="CCDS:CCDS11330.1"
                     /db_xref="GeneID:9349"
                     /db_xref="HGNC:HGNC:10316"
                     /db_xref="MIM:603662"
                     /translation="MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKG
                     IKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNA
                     GVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA"
     exon            25..108
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /inference="alignment:Splign:2.1.0"
     exon            109..237
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /inference="alignment:Splign:2.1.0"
     exon            238..351
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /inference="alignment:Splign:2.1.0"
     exon            352..2706
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      456..461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /note="hexamer: AATAAA"
     regulatory      478..483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /note="hexamer: ATTAAA"
     polyA_site      478
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /note="major polyA site"
     polyA_site      485
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
     regulatory      1332..1337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /note="hexamer: AGTAAA"
     polyA_site      1356
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /note="hexamer: AATACA"
     polyA_site      1789
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
     regulatory      2680..2685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
                     /note="hexamer: ATTAAA"
     polyA_site      2706
                     /gene="RPL23"
                     /gene_synonym="L23; rpL17; uL14"
ORIGIN      
        1 cggcgttcaa gatgtcgaag cgaggacgtg gtgggtcctc tggtgcgaaa ttccggattt
       61 ccttgggtct tccggtagga gctgtaatca attgtgctga caacacagga gccaaaaacc
      121 tgtatatcat ctccgtgaag gggatcaagg gacggctgaa cagacttccc gctgctggtg
      181 tgggtgacat ggtgatggcc acagtcaaga aaggcaaacc agagctcaga aaaaaggtac
      241 atccagcagt ggtcattcga caacgaaagt cataccgtag aaaagatggc gtgtttcttt
      301 attttgaaga taatgcagga gtcatagtga acaataaagg cgagatgaaa ggttctgcca
      361 ttacaggacc agtagcaaag gagtgtgcag acttgtggcc ccggattgca tccaatgctg
      421 gcagcattgc atgattctcc agtatatttg taaaaaataa aaaaaaaaac taaacccatt
      481 aaaaagtatt tgtttgcagt gcttgtctcc ctgttcactt ccagggttca agcgattctc
      541 ctgcctcagc ctcctaagta gctgggatta caggcacctg ccgtcatgcc tggctagttt
      601 ttgtattttt ggtggagaca gggtttcacc atgtttgcca aacgactcaa actcctgatc
      661 tcaagtgatc tgcccaccca ggcctctaca gtgtttttga cataccctga ccatcacttt
      721 tctgaaatgg aaactctggg catttttttt ttaaagcaat ccttgctttt ttgtgagttt
      781 gcagactttc agcatcttcc aattgctgta tttacaattt tggcctcaaa aagtattatt
      841 tgggttttga gtcccaaaaa taatagtaga tactgctcaa tgactggcta tacatggtag
      901 cttctcctgg agtgaggaag gcattcaaat ggctgggcgc ggtagctggc acctgtaatc
      961 ccaacacttt cggaggccaa ggcaggcaga tcatgaggtc aggagttcaa gaccaggctg
     1021 accaacgtgg tgaaacctcc tcttttctaa aaatacaaaa attagctggg cgtggtggcg
     1081 caccgcctgt aatctcagct actgagagaa tcgcttgaac ctgggaggtg gagtttgcag
     1141 cgagtcgaga ttgcaccatt gtactccatc cagcctgggc aacggagcaa gattccgttc
     1201 ccgcccccgc cccaaaaaaa ggcattgaag ttaagataga ctatatagtt agatcctgga
     1261 cacacacatg gattttgagg aatgatgtga gtttgtttat gtatgtacat tttagcagtt
     1321 aacagatttg gagtaaattg aatatttata aaacaacagt aattgccatg taggtttact
     1381 gtcatagtgg aagatgatta agttgatggt acctacaggt attttgctat gaaaatgttt
     1441 tgacaaacag gatgatcgtg taatttatgt tccaagctct agtttgagaa tggaagaatg
     1501 tggtaaattt ttgccaactg aacaggcata aagcgctgat aataagggac ttggccttaa
     1561 ggtaggaggt tgttagcatt tctttctaaa cgtgtaagag tttatttagg tgacacccag
     1621 cgttttggaa aaatgggtgt ttgtttagaa caataatttg gagggaagtg gactaaacag
     1681 ggtttttaga ttaaggtttg tgtttatgta tctgtatctg caaatactca gccataaatg
     1741 tttctacctg taagttgggt ataatacaag ctccacttgg tatcaaaaag gactaccctt
     1801 agtgtcttcc atgactagtt atggaatgta ccagacctag agaggagttg ttctaacctg
     1861 gagcttttga aaatgtttcc ggtccatacc ctagaccaat taagtcagac tgcagaatag
     1921 gactcagaca tcagaattgt gaagctccca ggagatgtca aggtataccc aagactgaga
     1981 accagtaccc tgtctagact gaaccaggct tggttttaga agtattaaat ctcgcctggg
     2041 tacggtggct cacacctata atcccagcac tttgggaggc tgaggtgggt ggatcatctg
     2101 aggtcaggag agtgagacca gcctgtccaa catgttgaaa ccccatctct actatacaaa
     2161 attagccagg catggtggtg catgctgtaa tcccagctac ttgggaggct gaggcaggag
     2221 aattgcttga accccggaga tggaggttgc agtgagctga ggtcgcacga ttgtgctcca
     2281 gcctgggcaa ccagtgaaac tctgggggga aagaaaaaaa atgtattaaa tctctagttt
     2341 tagagagtta caccataaca tccctgagta tggtcaattt caagtcagct ttagtgtgac
     2401 aagcccctag gcccaccatt tatgtcttta tatattatgg caatatatga tccttatata
     2461 ttaaccacta atcgctgctg tttttgaatg ttatcttttc tgaggcagtc ttgctctgtc
     2521 acacaggctg gagtgcagta acaccactga agctcactgt aactttgaac tgctggactt
     2581 ggaatcctcc tgctgtggcc ttcaaagggc tgcaattaca agtgtgagcc actgcatccc
     2641 acctcacatt ttattctttg gagatttttt ttgacttgga ttaaaaaact ttatatttac
     2701 acttca
//
