LOCUS       NM_001099645            1902 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L22 like 1 (RPL22L1), transcript
            variant 1, mRNA.
ACCESSION   NM_001099645 XM_001132475 XM_001132707
VERSION     NM_001099645.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1902)
  AUTHORS   Yi,X., Zhang,C., Liu,B., Gao,G., Tang,Y., Lu,Y., Pan,Z., Wang,G.
            and Feng,W.
  TITLE     Ribosomal protein L22-like1 promotes prostate cancer progression by
            activating PI3K/Akt/mTOR signalling pathway
  JOURNAL   J Cell Mol Med 27 (3), 403-411 (2023)
   PUBMED   36625246
  REMARK    GeneRIF: Ribosomal protein L22-like1 promotes prostate cancer
            progression by activating PI3K/Akt/mTOR signalling pathway.
REFERENCE   2  (bases 1 to 1902)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1902)
  AUTHORS   Rao,S., Peri,S., Hoffmann,J., Cai,K.Q., Harris,B., Rhodes,M.,
            Connolly,D.C., Testa,J.R. and Wiest,D.L.
  TITLE     RPL22L1 induction in colorectal cancer is associated with poor
            prognosis and 5-FU resistance
  JOURNAL   PLoS One 14 (10), e0222392 (2019)
   PUBMED   31581233
  REMARK    GeneRIF: RPL22L1 might be a prognostic marker in colorectal cancer
            and predict 5-Fluorouracil responsiveness.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1902)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062731.1, AC061708.17 and CA449264.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001099645.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.167320.1,
                                           SRR1660809.144861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149876, SAMN03267778
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295830.13/ ENSP00000346080.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-464               BC062731.1         5-468
            465-1861            AC061708.17        10155-11551         c
            1862-1902           CA449264.1         16-56               c
FEATURES             Location/Qualifiers
     source          1..1902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..1902
                     /gene="RPL22L1"
                     /note="ribosomal protein L22 like 1"
                     /db_xref="GeneID:200916"
                     /db_xref="HGNC:HGNC:27610"
     exon            1..37
                     /gene="RPL22L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..397
                     /gene="RPL22L1"
                     /EC_number="3.6.5.3"
                     /note="isoform 1 is encoded by transcript variant 1; 60S
                     ribosomal protein L22-like 1; large ribosomal subunit
                     protein eL22-like 1; ribosomal protein eL22-like"
                     /codon_start=1
                     /product="ribosomal protein eL22-like isoform 1"
                     /protein_id="NP_001093115.1"
                     /db_xref="CCDS:CCDS46955.1"
                     /db_xref="GeneID:200916"
                     /db_xref="HGNC:HGNC:27610"
                     /translation="MAPQKDRKPKRSTWRFNLDLTHPVEDGIFDSGNFEQFLREKVKV
                     NGKTGNLGNVVHIERFKNKITVVSEKQFSKRYLKYLTKKYLKKNNLRDWLRVVASDKE
                     TYELRYFQISQDEDESESED"
     exon            38..130
                     /gene="RPL22L1"
                     /inference="alignment:Splign:2.1.0"
     exon            131..252
                     /gene="RPL22L1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..1902
                     /gene="RPL22L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      490..495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL22L1"
                     /note="hexamer: AATAAA"
     polyA_site      513
                     /gene="RPL22L1"
                     /note="major polyA site"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL22L1"
                     /note="hexamer: AATAAA"
     polyA_site      1358
                     /gene="RPL22L1"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL22L1"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="RPL22L1"
ORIGIN      
        1 ctctctgctc tcgcggccga ctcgcaagat ggcgccgcag aaagacagga agcccaagag
       61 gtcaacctgg aggtttaatt tggaccttac tcatccagta gaagatggaa tttttgattc
      121 tggaaatttt gagcaatttc tacgggagaa ggttaaagtc aatggcaaaa ctggaaatct
      181 cgggaatgtt gttcacattg aacgcttcaa gaataaaatc acagttgttt ctgagaaaca
      241 gttctctaaa aggtatttga aataccttac caagaaatac cttaagaaga acaatcttcg
      301 tgattggctt cgagtggttg catctgacaa ggagacctac gaacttcgtt acttccagat
      361 tagtcaagat gaagatgaat cagagtcgga ggactaggca aaggctcccc ttacagggct
      421 ttgcttatta ataaaataaa tgaagtatac atgagaaata ccaagaaatt ggcttttagt
      481 ttatcagtga ataaaaaata ttatactctt gaacttttgt ctcatttttt tgagtatgct
      541 gtttatatga ttttgatttc cctctgataa ctatcaacag tatttaaata gcttatagct
      601 ggtataattt tttcccacga tttccaaaat cttttatgta ctcaggtaaa agtagcgtta
      661 tataggaaat ctttttttta gacactctcg ttctgtcacc caggctggag tgcagtgact
      721 cagcttccta aatagctgga attacaggtg tgagccacca tgcccggcta attttttgta
      781 cttttagtag agtagggttt ggccatgttg gccaggctgg tttcaaactc ctgacctcaa
      841 gtgatctacc cacctcggct tcccaaagtg ctgattatag ctgtgaacca ccatgcccgg
      901 ccaggaaatc ttactgtaga acaatttttt atatagctgt ataaaatgta tatgattgtc
      961 ttgacagtct caaatactgt ttttaatagc ttgtaaatgt aatctcaagt gcttagaaca
     1021 gttcttacat ataagttgct ctgtagtttg ctcttatagt tagcccaaag actctgggtg
     1081 tgaggcctgc tgtaaaccaa tgttaaactg cttattagaa agccctaacc acctgctttg
     1141 taggcaccag aaactcaaaa ccaaatctca actcagctac agaatctact gtggtccttg
     1201 tctgaaaaaa ttagttcact cggttggaat cttgtctcag agcatcctca tctctttctc
     1261 aaaagcccct accccaacac cggcgtgttg gttgtctatt gaaacttaca agtggatgga
     1321 ccctttctcc cgaataaact ggcctttgaa agctctaatc gaaatggttt ggcaaaatcc
     1381 atactgcagg agattaggga ggacaagaat gatgtgcctt tttgtactgc tgagcctgat
     1441 ggtggtgcca ctacttcagg tacttagatg agtcttgatg ctaatagaat tgtgtcgcca
     1501 aacatatctg gacagttaca acctaatcta tgcattaatt ggtttgggaa ttgcttgaaa
     1561 ttattgttta attcaatgtt ttaattcgtt ttcctaaaaa tttaagtgcc cccatcatcg
     1621 tgcaatacct cagtgcagca actccttgat tcttggatga ctgaacttcc taacttggct
     1681 ctgccccatt gttcccattt ttcatgtttt tcacaaatag ttaaccaggt acctactact
     1741 gtgcaccgct gcagagcatt gaggatgtat gtgatgagta aaaacaccca gcctgctctg
     1801 ctgtgttagt attatgacgg aaactgatca aatcacatgt gaacaaattt actgctacaa
     1861 aagggagggc ttaataaaag gaatttcatc tgggaaggca aa
//
