LOCUS       NM_000983               2061 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens ribosomal protein L22 (RPL22), mRNA.
ACCESSION   NM_000983
VERSION     NM_000983.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2061)
  AUTHORS   Li,H.Y., Wang,M., Jiang,X., Jing,Y., Wu,Z., He,Y., Yan,K., Sun,S.,
            Ma,S., Ji,Z., Wang,S., Belmonte,J.C.I., Qu,J., Zhang,W., Wei,T. and
            Liu,G.H.
  TITLE     CRISPR screening uncovers nucleolar RPL22 as a heterochromatin
            destabilizer and senescence driver
  JOURNAL   Nucleic Acids Res 52 (19), 11481-11499 (2024)
   PUBMED   39258545
  REMARK    GeneRIF: CRISPR screening uncovers nucleolar RPL22 as a
            heterochromatin destabilizer and senescence driver.
REFERENCE   2  (bases 1 to 2061)
  AUTHORS   Cheng,J., Sha,Z., Zhang,R., Ge,J., Chen,P., Kuang,X., Chang,J.,
            Ren,K., Luo,X., Chen,S. and Gou,X.
  TITLE     L22 ribosomal protein is involved in dynamin-related protein
            1-mediated gastric carcinoma progression
  JOURNAL   Bioengineered 13 (3), 6650-6664 (2022)
   PUBMED   35230214
  REMARK    GeneRIF: L22 ribosomal protein is involved in dynamin-related
            protein 1-mediated gastric carcinoma progression.
REFERENCE   3  (bases 1 to 2061)
  AUTHORS   Zeng,J., Zhang,Y., Zhang,H., Zhang,Y., Gao,L., Tong,X., Xie,Y.,
            Hu,Q., Chen,C., Ding,S. and Lu,J.
  TITLE     RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing
            Keratinocytes Abnormal Biological Behavior
  JOURNAL   Front Immunol 12, 699900 (2021)
   PUBMED   34220863
  REMARK    GeneRIF: RPL22 Overexpression Promotes Psoriasis-Like Lesion by
            Inducing Keratinocytes Abnormal Biological Behavior.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2061)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2061)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2061)
  AUTHORS   Shu-Nu,C., Lin,C.H. and Lin,A.
  TITLE     An acidic amino acid cluster regulates the nucleolar localization
            and ribosome assembly of human ribosomal protein L22
  JOURNAL   FEBS Lett 484 (1), 22-28 (2000)
   PUBMED   11056215
REFERENCE   7  (bases 1 to 2061)
  AUTHORS   Le,S., Sternglanz,R. and Greider,C.W.
  TITLE     Identification of two RNA-binding proteins associated with human
            telomerase RNA
  JOURNAL   Mol Biol Cell 11 (3), 999-1010 (2000)
   PUBMED   10712515
REFERENCE   8  (bases 1 to 2061)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 2061)
  AUTHORS   Fujita,Y., Okamoto,T., Noshiro,M., McKeehan,W.L., Crabb,J.W.,
            Whitney,R.G., Kato,Y., Sato,J.D. and Takada,K.
  TITLE     A novel heparin-binding protein, HBp15, is identified as mammalian
            ribosomal protein L22
  JOURNAL   Biochem Biophys Res Commun 199 (2), 706-713 (1994)
   PUBMED   8135813
REFERENCE   10 (bases 1 to 2061)
  AUTHORS   Toczyski,D.P. and Steitz,J.A.
  TITLE     EAP, a highly conserved cellular protein associated with
            Epstein-Barr virus small RNAs (EBERs)
  JOURNAL   EMBO J 10 (2), 459-466 (1991)
   PUBMED   1846807
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from CA336134.1, AK097075.1 and AF113701.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000983.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a cytoplasmic
            ribosomal protein that is a component of the 60S subunit. The
            protein belongs to the L22E family of ribosomal proteins. Its
            initiating methionine residue is post-translationally removed. The
            protein can bind specifically to Epstein-Barr virus-encoded RNAs
            (EBERs) 1 and 2. The mouse protein has been shown to be capable of
            binding to heparin. Transcript variants utilizing alternative polyA
            signals exist. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. It was previously thought that this gene mapped
            to 3q26 and that it was fused to the acute myeloid leukemia 1
            (AML1) gene located at 21q22 in some therapy-related
            myelodysplastic syndrome patients with 3;21 translocations;
            however, these fusions actually involve a ribosomal protein L22
            pseudogene located at 3q26, and this gene actually maps to
            1p36.3-p36.2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.436838.1,
                                           SRR3476690.1039763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234875.9/ ENSP00000346088.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               CA336134.1         28-493
            467-2060            AK097075.1         450-2043
            2061-2061           AF113701.1         1548-1548
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..2061
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /note="ribosomal protein L22"
                     /db_xref="GeneID:6146"
                     /db_xref="HGNC:HGNC:10315"
                     /db_xref="MIM:180474"
     exon            1..34
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..409
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /EC_number="2.1.1.100"
                     /note="60S ribosomal protein L22; Epstein-Barr-encoded
                     RNA-associated protein; Epstein-Barr virus small
                     RNA-associated protein; EBER-associated protein;
                     heparin-binding protein 15; heparin-binding protein HBp15"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL22"
                     /protein_id="NP_000974.1"
                     /db_xref="CCDS:CCDS58.1"
                     /db_xref="GeneID:6146"
                     /db_xref="HGNC:HGNC:10315"
                     /db_xref="MIM:180474"
                     /translation="MAPVKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQ
                     ERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRV
                     VANSKESYELRYFQINQDEEEEEDED"
     exon            35..139
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /inference="alignment:Splign:2.1.0"
     exon            140..264
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /inference="alignment:Splign:2.1.0"
     exon            265..2061
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      840..845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /note="hexamer: AATAAA"
     polyA_site      863
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /note="major polyA site"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
                     /note="hexamer: ATTAAA"
     polyA_site      2061
                     /gene="RPL22"
                     /gene_synonym="EAP; eL22; HBP15; HBP15/L22; L22"
ORIGIN      
        1 cctttctaac tccgctgccg ccatggctcc tgtgaaaaag cttgtggtga aggggggcaa
       61 aaaaaagaag caagttctga agttcactct tgattgcacc caccctgtag aagatggaat
      121 catggatgct gccaattttg agcagttttt gcaagaaagg atcaaagtga acggaaaagc
      181 tgggaacctt ggtggagggg tggtgaccat cgaaaggagc aagagcaaga tcaccgtgac
      241 atccgaggtg cctttctcca aaaggtattt gaaatatctc accaaaaaat atttgaagaa
      301 gaataatcta cgtgactggt tgcgcgtagt tgctaacagc aaagagagtt acgaattacg
      361 ttacttccag attaaccagg acgaagaaga ggaggaagac gaggattaaa tttcatttat
      421 ctggaaaatt ttgtatgagt tcttgaataa aacttgggaa ccaaaatggt ggtttatcct
      481 tgtatctctg cagtgtggat tgaacagaaa attggaaatc atagtcaaag ggcttccctt
      541 ggttcgccac tcatttattt gtaacttgac ttcttttttt ttctgcttaa aaatttcaat
      601 tctcgtggta ataccagagt agaaggagag ggtgacttta ccgaactgac agccattggg
      661 gaggcagatg cgggtgtgga ggtgtgggct gaaggtagtg actgtttgat tttaaaaagt
      721 gtgactgtca gttgtatctg ttgcttttct caatgattca gggatacaaa tgggcttctc
      781 tcattcatta aaagaaaacg cgacatcttt ctaagattct ctgtgggaaa atgactgtca
      841 ataaaatgcg ggtttctggg ccattcgtct tactttcatt ttttgattac aaatttctct
      901 tgacgcacac aattatgtct gctaatcctc ttcttcctag agagagaaac tgtgctcctt
      961 cagtgttgct gccataaagg ggtttgggga atcgattgta aaagtcccag gttctaaatt
     1021 aactaaatgt gtacagaaat gaacgtgtaa gtaatgtttc tacaggtctt tgcaacaaac
     1081 tgtcactttc gtctccagca gagggagctg taggaatagt gcttccagat gtggtctccc
     1141 gtgtggggcc cagcaatggg ggcccctgat gccaagagct ctggaggttc ttgaaagagg
     1201 ggacacgaag gaggagtgac tgggaagcct cccatgccaa ggaggtggga ggtgccctgg
     1261 aaatagctgc ctcatgccac ttaggccatg actggattta atgtcagtgg tgtgccacag
     1321 tgcagaggct agacaactga aaggggctac caaggctggg aaaaaaatgc aattgttgct
     1381 gtgagtgact ttgaaagact ctggtgcctt gtggtgccct tctgaaattc aaacagtaat
     1441 gcaaaagtgt ctgcattaga atttacggtg tctaaaattc atgtttttaa aagagcttgc
     1501 ctacagatgg tttccacact tgaaattgtg ccctgcgagt tgcatagctg gaagttcaat
     1561 gctcagtcct accttggctc ccattaaaca tttggtgctc tgtggattga gttgaacgtg
     1621 ttgaggcttt gcaatttcac ttgtgttaaa ggctctggca tttttccatt tctatgcaaa
     1681 tttctttgaa gcagaattgc ttgcatattt cttctctgcc gtcacagaaa gcagagtttc
     1741 tttcaaactt cactgaggca tcagttgctc tttggcaatg tcccttaacc atgattatta
     1801 actaagtttg tggcttgagt ttacaaattc tacttgttgc attgatgttc ccatgtagta
     1861 agtcattttt agtttggttg tgaaaaaacc ctgggctgaa gttggcattt cagttaaaag
     1921 aaaaaaagaa actagtccca gatttgaaaa cttgtaataa aattgaaact cactggtttt
     1981 ctatgtcttt ttgaactctt gtaatcgagt tttgatcata ttttctatta aagtggctaa
     2041 cacctggcta ctcttactgt a
//
