LOCUS       NM_000982                566 bp    mRNA    linear   PRI 19-MAR-2024
DEFINITION  Homo sapiens ribosomal protein L21 (RPL21), mRNA.
ACCESSION   NM_000982 XM_374411
VERSION     NM_000982.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 566)
  AUTHORS   Khan,M.I.K., Charles,R.C.M., Ramachandran,R., Gupta,S.,
            Govindaraju,G., Mishra,R., Rajavelu,A., Coumar,M.S., Chavali,S. and
            Dhayalan,A.
  TITLE     The ribosomal protein eL21 interacts with the protein lysine
            methyltransferase SMYD2 and regulates its steady state levels
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (9), 119079 (2021)
   PUBMED   34147559
  REMARK    GeneRIF: The ribosomal protein eL21 interacts with the protein
            lysine methyltransferase SMYD2 and regulates its steady state
            levels.
REFERENCE   2  (bases 1 to 566)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 566)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   4  (bases 1 to 566)
  AUTHORS   Jefferson,M., Donaszi-Ivanov,A., Pollen,S., Dalmay,T., Saalbach,G.
            and Powell,P.P.
  TITLE     Host factors that interact with the pestivirus N-terminal protease,
            Npro, are components of the ribonucleoprotein complex
  JOURNAL   J Virol 88 (18), 10340-10353 (2014)
   PUBMED   24965446
REFERENCE   5  (bases 1 to 566)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   6  (bases 1 to 566)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 566)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 566)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim Biophys Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
REFERENCE   9  (bases 1 to 566)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (bases 1 to 566)
  AUTHORS   Albertsen,H.M., Smith,S.A., Mazoyer,S., Fujimoto,E., Stevens,J.,
            Williams,B., Rodriguez,P., Cropp,C.S., Slijepcevic,P., Carlson,M.
            et al.
  TITLE     A physical map and candidate genes in the BRCA1 region on
            chromosome 17q12-21
  JOURNAL   Nat Genet 7 (4), 472-479 (1994)
   PUBMED   7951316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AL159977.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 16, 2020 this sequence version replaced NM_000982.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L21E family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB110702.1, DA939474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311549.11/ ENSP00000346027.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL159977.10        78324-78351
            29-107              AL159977.10        80531-80609
            108-169             AL159977.10        80986-81047
            170-282             AL159977.10        82008-82120
            283-433             AL159977.10        82950-83100
            434-566             AL159977.10        83202-83334
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.2"
     gene            1..566
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /note="ribosomal protein L21"
                     /db_xref="GeneID:6144"
                     /db_xref="HGNC:HGNC:10313"
                     /db_xref="MIM:603636"
     exon            1..28
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /inference="alignment:Splign:2.1.0"
     exon            29..107
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..523
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L21"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL21"
                     /protein_id="NP_000973.2"
                     /db_xref="CCDS:CCDS9320.1"
                     /db_xref="GeneID:6144"
                     /db_xref="HGNC:HGNC:10313"
                     /db_xref="MIM:603636"
                     /translation="MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKG
                     MGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSR
                     DSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA
                     "
     exon            108..169
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /inference="alignment:Splign:2.1.0"
     exon            170..282
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /inference="alignment:Splign:2.1.0"
     exon            283..433
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /inference="alignment:Splign:2.1.0"
     exon            434..566
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      541..546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /note="hexamer: AATAAA"
     polyA_site      566
                     /gene="RPL21"
                     /gene_synonym="eL21; HYPT12; L21"
                     /note="major polyA site"
ORIGIN      
        1 cctttcggcc ggaaccgcca tcttccagta attcgccaaa atgacgaaca caaagggaaa
       61 gaggagaggc acccgatata tgttctctag gccttttaga aaacatggag ttgttccttt
      121 ggccacatat atgcgaatct ataagaaagg tgatattgta gacatcaagg gaatgggtac
      181 tgttcaaaaa ggaatgcccc acaagtgtta ccatggcaaa actggaagag tctacaatgt
      241 tacccagcat gctgttggca ttgttgtaaa caaacaagtt aagggcaaga ttcttgccaa
      301 gagaattaat gtgcgtattg agcacattaa gcactctaag agccgagata gcttcctgaa
      361 acgtgtgaag gaaaatgatc agaaaaagaa agaagccaaa gagaaaggta cctgggttca
      421 actaaagcgc cagcctgctc cacccagaga agcacacttt gtgagaacca atgggaagga
      481 gcctgagctg ctggaaccta ttccctatga attcatggca taataggtgt taaaaaaaaa
      541 aataaaggac ctctgggcta caaaaa
//
