LOCUS       NM_000981                737 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L19 (RPL19), transcript variant 1,
            mRNA.
ACCESSION   NM_000981 XM_001126177
VERSION     NM_000981.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 737)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 737)
  AUTHORS   Cai,Z., Wu,Y., Zhang,F. and Wu,H.
  TITLE     A three-gene signature and clinical outcome in pediatric acute
            myeloid leukemia
  JOURNAL   Clin Transl Oncol 23 (4), 866-873 (2021)
   PUBMED   32862280
  REMARK    GeneRIF: A three-gene signature and clinical outcome in pediatric
            acute myeloid leukemia.
REFERENCE   3  (bases 1 to 737)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 737)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 737)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   6  (bases 1 to 737)
  AUTHORS   Davies,B. and Fried,M.
  TITLE     The L19 ribosomal protein gene (RPL19): gene organization,
            chromosomal mapping, and novel promoter region
  JOURNAL   Genomics 25 (2), 372-380 (1995)
   PUBMED   7789970
REFERENCE   7  (bases 1 to 737)
  AUTHORS   Henry,J.L., Coggin,D.L. and King,C.R.
  TITLE     High-level expression of the ribosomal protein L19 in human breast
            tumors that overexpress erbB-2
  JOURNAL   Cancer Res 53 (6), 1403-1408 (1993)
   PUBMED   8095182
REFERENCE   8  (bases 1 to 737)
  AUTHORS   Kumabe,T., Sohma,Y. and Yamamoto,T.
  TITLE     Human cDNAs encoding elongation factor 1 gamma and the ribosomal
            protein L19
  JOURNAL   Nucleic Acids Res 20 (10), 2598 (1992)
   PUBMED   1598220
REFERENCE   9  (bases 1 to 737)
  AUTHORS   Feo,S., Davies,B. and Fried,M.
  TITLE     The mapping of seven intron-containing ribosomal protein genes
            shows they are unlinked in the human genome
  JOURNAL   Genomics 13 (1), 201-207 (1992)
   PUBMED   1577483
REFERENCE   10 (bases 1 to 737)
  AUTHORS   Chan,Y.L., Lin,A., McNally,J., Peleg,D., Meyuhas,O. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein L19. A determination
            from the sequence of nucleotides in a cDNA and from the sequence of
            amino acids in the protein
  JOURNAL   J Biol Chem 262 (3), 1111-1115 (1987)
   PUBMED   3542997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC095445.1 and CF129418.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2018 this sequence version replaced NM_000981.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L19E family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095445.1, SRR5189664.134613.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225430.9/ ENSP00000225430.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-727               BC095445.1         1-727
            728-737             CF129418.1         703-712
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..737
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /note="ribosomal protein L19"
                     /db_xref="GeneID:6143"
                     /db_xref="HGNC:HGNC:10312"
                     /db_xref="MIM:180466"
     exon            1..67
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..653
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /EC_number="6.3.5.5"
                     /note="isoform 1 is encoded by transcript variant 1; 60S
                     ribosomal protein L19; large ribosomal subunit protein
                     eL19"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL19 isoform 1"
                     /protein_id="NP_000972.1"
                     /db_xref="CCDS:CCDS42312.1"
                     /db_xref="GeneID:6143"
                     /db_xref="HGNC:HGNC:10312"
                     /db_xref="MIM:180466"
                     /translation="MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKL
                     IKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRIL
                     RRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAE
                     ARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK"
     exon            68..174
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /inference="alignment:Splign:2.1.0"
     exon            175..297
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /inference="alignment:Splign:2.1.0"
     exon            298..418
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /inference="alignment:Splign:2.1.0"
     exon            419..529
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /inference="alignment:Splign:2.1.0"
     exon            530..737
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      711..716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /note="hexamer: AATAAA"
     polyA_site      732
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /note="major polyA site"
ORIGIN      
        1 gcagataatg ggaggagccg ggcccgagcg agctctttcc tttcgctgct gcggccgcag
       61 ccatgagtat gctcaggctt cagaagaggc tcgcctctag tgtcctccgc tgtggcaaga
      121 agaaggtctg gttagacccc aatgagacca atgaaatcgc caatgccaac tcccgtcagc
      181 agatccggaa gctcatcaaa gatgggctga tcatccgcaa gcctgtgacg gtccattccc
      241 gggctcgatg ccggaaaaac accttggccc gccggaaggg caggcacatg ggcataggta
      301 agcggaaggg tacagccaat gcccgaatgc cagagaaggt cacatggatg aggagaatga
      361 ggattttgcg ccggctgctc agaagatacc gtgaatctaa gaagatcgat cgccacatgt
      421 atcacagcct gtacctgaag gtgaagggga atgtgttcaa aaacaagcgg attctcatgg
      481 aacacatcca caagctgaag gcagacaagg cccgcaagaa gctcctggct gaccaggctg
      541 aggcccgcag gtctaagacc aaggaagcac gcaagcgccg tgaagagcgc ctccaggcca
      601 agaaggagga gatcatcaag actttatcca aggaggaaga gaccaagaaa taaaacctcc
      661 cactttgtct gtacatactg gcctctgtga ttacatagat cagccattaa aataaaacaa
      721 gccttaatct gccttcc
//
