LOCUS       NP_000972                196 aa            linear   PRI 27-APR-2025
DEFINITION  large ribosomal subunit protein eL19 isoform 1 [Homo sapiens].
ACCESSION   NP_000972 XP_001126177
VERSION     NP_000972.1
DBSOURCE    REFSEQ: accession NM_000981.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 196)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 196)
  AUTHORS   Cai,Z., Wu,Y., Zhang,F. and Wu,H.
  TITLE     A three-gene signature and clinical outcome in pediatric acute
            myeloid leukemia
  JOURNAL   Clin Transl Oncol 23 (4), 866-873 (2021)
   PUBMED   32862280
  REMARK    GeneRIF: A three-gene signature and clinical outcome in pediatric
            acute myeloid leukemia.
REFERENCE   3  (residues 1 to 196)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (residues 1 to 196)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 196)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   6  (residues 1 to 196)
  AUTHORS   Davies,B. and Fried,M.
  TITLE     The L19 ribosomal protein gene (RPL19): gene organization,
            chromosomal mapping, and novel promoter region
  JOURNAL   Genomics 25 (2), 372-380 (1995)
   PUBMED   7789970
REFERENCE   7  (residues 1 to 196)
  AUTHORS   Henry,J.L., Coggin,D.L. and King,C.R.
  TITLE     High-level expression of the ribosomal protein L19 in human breast
            tumors that overexpress erbB-2
  JOURNAL   Cancer Res 53 (6), 1403-1408 (1993)
   PUBMED   8095182
REFERENCE   8  (residues 1 to 196)
  AUTHORS   Kumabe,T., Sohma,Y. and Yamamoto,T.
  TITLE     Human cDNAs encoding elongation factor 1 gamma and the ribosomal
            protein L19
  JOURNAL   Nucleic Acids Res 20 (10), 2598 (1992)
   PUBMED   1598220
REFERENCE   9  (residues 1 to 196)
  AUTHORS   Feo,S., Davies,B. and Fried,M.
  TITLE     The mapping of seven intron-containing ribosomal protein genes
            shows they are unlinked in the human genome
  JOURNAL   Genomics 13 (1), 201-207 (1992)
   PUBMED   1577483
REFERENCE   10 (residues 1 to 196)
  AUTHORS   Chan,Y.L., Lin,A., McNally,J., Peleg,D., Meyuhas,O. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein L19. A determination
            from the sequence of nucleotides in a cDNA and from the sequence of
            amino acids in the protein
  JOURNAL   J Biol Chem 262 (3), 1111-1115 (1987)
   PUBMED   3542997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC095445.1 and CF129418.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 20, 2006 this sequence version replaced XP_001126177.1.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L19E family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095445.1, SRR5189664.134613.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225430.9/ ENSP00000225430.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     Protein         1..196
                     /product="large ribosomal subunit protein eL19 isoform 1"
                     /EC_number="6.3.5.5"
                     /note="60S ribosomal protein L19; large ribosomal subunit
                     protein eL19"
                     /calculated_mol_wt=23335
     Region          4..167
                     /region_name="Ribosomal_L19e_E"
                     /note="Ribosomal protein L19e, eukaryotic. L19e is found
                     in the large ribosomal subunit of eukaryotes and archaea.
                     L19e is distinct from the ribosomal subunit L19, which is
                     found in prokaryotes. It consists of two small globular
                     domains connected by an...; cd01417"
                     /db_xref="CDD:238705"
     Site            order(4,8..9,18..24,26,29,38,42,53,55..60,62,64,66..67,
                     69..70,72,74..79,81..89,92,95..97,100..101,103,110,
                     117..118,120..121,124..126,129,131,134..135)
                     /site_type="other"
                     /note="protein-rRNA interface [nucleotide binding]"
                     /db_xref="CDD:238705"
     Site            13
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (P84098.1)"
     Site            28..47
                     /site_type="active"
                     /note="putative translocon docking site [active]"
                     /db_xref="CDD:238705"
     Site            order(112..113,115..119,139..149)
                     /site_type="active"
                     /note="putative intersubunit bridge [active]"
                     /db_xref="CDD:238705"
     Region          157..176
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P84098.1)"
     Site            164
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P84098.1)"
     Site            187
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P84098.1)"
     CDS             1..196
                     /gene="RPL19"
                     /gene_synonym="eL19; L19"
                     /coded_by="NM_000981.4:63..653"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS42312.1"
                     /db_xref="GeneID:6143"
                     /db_xref="HGNC:HGNC:10312"
                     /db_xref="MIM:180466"
ORIGIN      
        1 msmlrlqkrl assvlrcgkk kvwldpnetn eianansrqq irklikdgli irkpvtvhsr
       61 arcrkntlar rkgrhmgigk rkgtanarmp ekvtwmrrmr ilrrllrryr eskkidrhmy
      121 hslylkvkgn vfknkrilme hihklkadka rkklladqae arrsktkear krreerlqak
      181 keeiiktlsk eeetkk
//
