LOCUS       NM_000980                634 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L18a (RPL18A), mRNA.
ACCESSION   NM_000980
VERSION     NM_000980.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 634)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 634)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 634)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   4  (bases 1 to 634)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 634)
  AUTHORS   Dhar,D., Mapa,K., Pudi,R., Srinivasan,P., Bodhinathan,K. and Das,S.
  TITLE     Human ribosomal protein L18a interacts with hepatitis C virus
            internal ribosome entry site
  JOURNAL   Arch Virol 151 (3), 509-524 (2006)
   PUBMED   16195786
  REMARK    GeneRIF: L18a might influence the HCV IRES mediated translation.
REFERENCE   6  (bases 1 to 634)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   7  (bases 1 to 634)
  AUTHORS   Jakel,S., Mingot,J.M., Schwarzmaier,P., Hartmann,E. and Gorlich,D.
  TITLE     Importins fulfil a dual function as nuclear import receptors and
            cytoplasmic chaperones for exposed basic domains
  JOURNAL   EMBO J 21 (3), 377-386 (2002)
   PUBMED   11823430
REFERENCE   8  (bases 1 to 634)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   9  (bases 1 to 634)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 634)
  AUTHORS   Gramatikoff,K., Schaffner,W. and Georgiev,O.
  TITLE     The leucine zipper of c-Jun binds to ribosomal protein L18a: a role
            in Jun protein regulation?
  JOURNAL   Biol Chem Hoppe Seyler 376 (5), 321-325 (1995)
   PUBMED   7662174
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from HY050156.1, BC007512.2 and BI753938.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000980.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a member of the
            L18AE family of ribosomal proteins that is a component of the 60S
            subunit. The encoded protein may play a role in viral replication
            by interacting with the hepatitis C virus internal ribosome entry
            site (IRES). This gene is co-transcribed with the U68 snoRNA,
            located within the third intron. As is typical for genes encoding
            ribosomal proteins, there are multiple processed pseudogenes of
            this gene dispersed throughout the genome. [provided by RefSeq, Jul
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD174123.1, CD173034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222247.10/ ENSP00000222247.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                HY050156.1         34-61
            29-625              BC007512.2         1-597
            626-634             BI753938.1         602-610
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..634
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /note="ribosomal protein L18a"
                     /db_xref="GeneID:6142"
                     /db_xref="HGNC:HGNC:10311"
                     /db_xref="MIM:604178"
     exon            1..65
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..578
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /note="60S ribosomal protein L18a; ribosomal protein
                     L18a-like protein"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL20"
                     /protein_id="NP_000971.1"
                     /db_xref="CCDS:CCDS12367.1"
                     /db_xref="GeneID:6142"
                     /db_xref="HGNC:HGNC:10311"
                     /db_xref="MIM:604178"
                     /translation="MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRF
                     WYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTT
                     AGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLR
                     RQHKPRFTTKRPNTFF"
     exon            66..245
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /inference="alignment:Splign:2.1.0"
     exon            246..375
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /inference="alignment:Splign:2.1.0"
     exon            376..485
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /inference="alignment:Splign:2.1.0"
     exon            486..634
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      608..613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /note="hexamer: AATAAA"
     polyA_site      634
                     /gene="RPL18A"
                     /gene_synonym="eL20; L18A"
                     /note="major polyA site"
ORIGIN      
        1 agaggacact tccttttgcg ggtggcggcg aacgcggaga gcacgccatg aaggcctcgg
       61 gcacgctacg agagtacaag gtagtgggtc gctgcctgcc cacccccaaa tgccacacgc
      121 cgcccctcta ccgcatgcga atctttgcgc ctaatcatgt cgtcgccaag tcccgcttct
      181 ggtactttgt atctcagtta aagaagatga agaagtcttc aggggagatt gtctactgtg
      241 ggcaggtgtt tgagaagtcc cccctgcggg tgaagaactt cgggatctgg ctgcgctatg
      301 actcccggag cggcacccac aacatgtacc gggaataccg ggacctgacc accgcaggcg
      361 ctgtcaccca gtgctaccga gacatgggtg cccggcaccg cgcccgagcc cactccattc
      421 agatcatgaa ggtggaggag atcgcggcca gcaagtgccg ccggccggct gtcaagcagt
      481 tccacgactc caagatcaag ttcccgctgc cccaccgggt cctgcgccgt cagcacaagc
      541 cacgcttcac caccaagagg cccaacacct tcttctaggt gcagggccct cgtccgggtg
      601 tgccccaaat aaactcagga acgccccggt gctc
//
